Isbn: 9783843370233 - Endocrine Disruptors - A Major Medical Challenge: An Impact of Endocrine Disruptors on Endocrine System: Their Estrogenic Mechanism in in Vitro and in Vivo Models (7 results)

Condition: New. pp. 116.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established. 116 pp. Englisch. …

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.…

Condition: New. Print on Demand pp. 116 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dang Hoang VuHoang Vu Dang earned his Master and continued his study for Ph.D. training program at Chungbuk National University in Korea. After graduate, he has been awarded U.S. NIH funded postdoctoral fellowship in University of.…

Condition: New. PRINT ON DEMAND pp. 116.

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.…