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Endocrine Disruptors - A Major Medical Challenge: An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models - Softcover
Synopsis
Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.
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About the Author
Hoang Vu Dang earned his Master and continued his study for Ph.D. training program at Chungbuk National University in Korea. After graduate, he has been awarded U.S. NIH funded postdoctoral fellowship in University of Rhode Island. Currently, he is working as JSPS postdoctoral fellow in Research Team for Advanced Biologics of NIAH in JAPAN
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Endocrine Disruptors - A Major Medical Challenge
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LAP LAMBERT Academic Publishing Okt 2010, 2010
ISBN 10: 3843370230
ISBN 13: 9783843370233
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established. 116 pp. Englisch. Seller Inventory # 9783843370233
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Endocrine Disruptors - A Major Medical Challenge
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Endocrine Disruptors - A Major Medical Challenge
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dang Hoang VuHoang Vu Dang earned his Master and continued his study for Ph.D. training program at Chungbuk National University in Korea. After graduate, he has been awarded U.S. NIH funded postdoctoral fellowship in University of. Seller Inventory # 5466943
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Endocrine Disruptors - A Major Medical Challenge : An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models
Published by
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3843370230
ISBN 13: 9783843370233
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established. Seller Inventory # 9783843370233
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Endocrine Disruptors - A Major Medical Challenge
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Endocrine Disruptors - A Major Medical Challenge
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3843370230
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Endocrine Disruptors - A Major Medical Challenge
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LAP LAMBERT Academic Publishing Okt 2010, 2010
ISBN 10: 3843370230
ISBN 13: 9783843370233
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch. Seller Inventory # 9783843370233
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Endocrine Disruptors - A Major Medical Challenge | An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models
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ISBN 13: 9783843370233
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Taschenbuch. Condition: Neu. Endocrine Disruptors - A Major Medical Challenge | An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models | Hoang Vu Dang | Taschenbuch | 116 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783843370233 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 107239051