Endocrine Disruptors - A Major Medical Challenge

Language: English

Published by LAP LAMBERT Academic Publishing Okt 2010, 2010

3843370230 / 9783843370233

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This item is printed on demand - Print on Demand Titel. Neuware -Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.…

Seller Inventory # 9783843370233

Title
Endocrine Disruptors - A Major Medical Challenge
Author
Hoang Vu Dang
Publisher
LAP LAMBERT Academic Publishing Okt 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3843370230
ISBN 13
9783843370233
Item weight
191 grams
Dimensions
220x150x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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