Speck James A (49 results)
More imagesPublished by The College of William and Mary, Williamsburg, 1982
- Softcover
- First Edition
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Paperback. Condition: Near Fine. First Edition. The College of William and Mary Near Fine. 1982. First Edition. Softcover. First edition. Magazine. Pictorial wrappers [about 6" x 9"], perfect-bound, 115 pages, illustrated. Near Fine copy whb11.
- Softcover
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
- Softcover
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- Softcover
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Condition: New. pp. 384 2nd Edition.
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Condition: New. pp. 384.
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Condition: New. pp. 384.
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- Softcover
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Paperback / softback. Condition: New. New copy - Usually dispatched within 4 working days.
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Speck, J: Mechanical Fastening, Joining, and Assembly
James A. Speck (The Johnson Gage Company, Bloomfield, Connecticut, USA)
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Kartoniert / Broschiert. Condition: New.
- Softcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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Paperback. Condition: Brand New. 2nd new edition. 400 pages. 9.25x6.14x0.87 inches. In Stock.
Language: English
Published by Springer, 2017
Series: Advances in Experimental Medicine and Biology, Book 282 of 544. Book 282 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
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Condition: very_good. This books is in Very good condition. There may be a few flaws like shelf wear and some light wear.
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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. Neuware.
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Taschenbuch. Condition: Neu. Gallium Nitride and Related Materials | Device Processing and Materials Characterization for Power Electronics Applications | Isik C. Kizilyalli (u. a.) | Taschenbuch | The Materials Research Society Series | xxix | Englisch | 2026 | Springer | EAN 9783031830587 | Verantwortliche Person für die EU: S…pringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
- Hardcover
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- Hardcover
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Condition: New.
Language: English
Published by Springer Verlag, Singapore, Singapore, 2017
Series: Advances in Experimental Medicine and Biology, Book 282 of 544. Book 282 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.Grand Eagle Retail
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Hardcover. Condition: new. Hardcover. This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal developme…nt. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both gatekeepers that modulate p53 responses and caretakers that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
- Hardcover
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Condition: New. pp. 376 67 lines of equations/ 68 total equations.
Speck, J: Mechanical Fastening, Joining, and Assembly
James A. Speck (The Johnson Gage Company, Bloomfield, Connecticut, USA)
- Hardcover
Seller: moluna, Greven, Germanymoluna
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Gebunden. Condition: New.
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Condition: New. pp. 376 2nd Edition.
- Hardcover
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Condition: As New. Unread book in perfect condition.
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- Hardcover
Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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Condition: New. pp. 376.
Language: English
Published by Springer Nature Singapore, Springer Nature Singapore, 2018
Series: Advances in Experimental Medicine and Biology, Book 282 of 544. Book 282 of 544 - Advances in Experimental Medicine and Biology
- Softcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific… roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both 'gatekeepers' that modulate p53 responses and 'caretakers' that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV.At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
Language: English
Published by Springer, 2017
Series: Advances in Experimental Medicine and Biology, Book 282 of 544. Book 282 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
Seller: Books Puddle, New York, NY, U.S.A.Books Puddle
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Condition: New. pp. 515 1st ed. 2017 edition NO-PA16APR2015-KAP.
