Nimesh Surendra (61 results)

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Condition: New. Ramesh Chandra, Surendra NimeshGene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability .

Taschenbuch. Condition: Neu. Neuware - Gene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can protect and efficiently transport siRNA to the target cells. Nanotechnology based non-viral vectors have been proposed as a potential alternate. Various polymeric nanoparticles have been shown as suitable delivery candidates with high cellular uptake efficiencies and advantage of reduced cytotoxicity. These delivery vectors form condensed complexes with siRNA which in turn provides protection to siRNA from enzymatic degradation and further leads to enhanced tissue and cellular targeting. Nanoparticles prepared from various polymers like polyethylenimine, chitosan have been largely exploited, as they bear several advantages such as, easy manipulatibility, high stability, low cost and high payload. Though numerous publications have appeared in the literature, there was still need to get more information under one roof, as book compilation which could provide a systematic account of all the aspects of nanotechnology mediated gene silencing right from the preparation of nanoparticles to in vitro and in vivo characterization followed by various applications in vitro and in vivo models. This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.The important topics discussed in the book include:-¿ Introduction to Nanotechnology¿ Physicochemical Characterization of Nanoparticles¿ In Vitro and In Vivo Characterization of Nanoparticles¿ Concept and Barriers to Gene Silencing¿ Nanoparticles Mediated Targeted siRNA delivery¿ Polymers for siRNA Delivery¿ Chitosan¿ Polyethylenimine¿ Poly-L-lysine¿ Atelocollagen¿ Protamine¿ Dendrimers¿ Cyclodextrin¿ Poly (D, L-lactide-co-glycolide)¿ Nanomaterials for siRNA delivery; Keyword Index.…

Taschenbuch. Condition: Neu. Polymeric Nanoparticles for Efficient in vitro Gene Delivery | Potential Application of Polyethylenimine in Gene Delivery | Surendra Nimesh | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659104572 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. …

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Paperback. Condition: new. Paperback. The Design & Development of Novel Drugs and Vaccines: Integrated Computational and Experimental Approaches Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Paperback. Condition: new. Paperback. Cancer Therapy: Potential Applications of Nanotechnology Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Taschenbuch. Condition: Neu. The Design and Development of Novel Drugs and Vaccines | Principles and Protocols | Tarun Kumar Bhatt (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2021 | Elsevier Science | EAN 9780128214718 | Verantwortliche Person für die EU: Elsevier B.V., Radarweg 29, 1043 NX AMSTERDAM, NIEDERLANDE, productsafety[at]elsevier[dot]com | Anbieter: preigu.…

Condition: New. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the .