Manirujjaman (17 results)

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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 76 pp. Englisch.

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted against time to get the zero order plots. In the zero order plots no true straight lines were obtained but statistically significant differences were found among the release profile.…

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Arafat MohammadMohammad Arafat is a Swedish Institute scholar studying Master s in Biomedicine & Methods in Medical Diagnostics,Experimental Medicine, having a M.S. degree in Pharmaceutical Technology. He worked previously at BDPF of.…

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book explores the development and evaluation of a controlled-release three-layered matrix tablet of diclofenac sodium, designed to achieve more consistent drug delivery than conventional dosage forms. The multilayer system combines a drug-containing core with two outer layers that differ in their swelling, gelling, and erosion properties, enabling modulation of the drug release rate and improving release kinetics. Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), serves as the model drug to investigate the influence of polymer composition and layer configuration on release behavior. Various formulations were prepared and compared through in vitro dissolution studies, with release profiles analyzed using zero-order kinetics. Although perfectly linear zero-order release was not achieved, statistically significant differences among the formulations demonstrate the impact of polymer matrices and tablet design on controlled drug delivery. The book provides valuable insights for students, researchers, and pharmaceutical scientists interested in modified-release dosage forms and formulation development. …

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book explores the development and evaluation of a controlled-release three-layered matrix tablet of diclofenac sodium, designed to achieve more consistent drug delivery than conventional dosage forms. The multilayer system combines a drug-containing core with two outer layers that differ in their swelling, gelling, and erosion properties, enabling modulation of the drug release rate and improving release kinetics. Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), serves as the model drug to investigate the influence of polymer composition and layer configuration on release behavior. Various formulations were prepared and compared through in vitro dissolution studies, with release profiles analyzed using zero-order kinetics. Although perfectly linear zero-order release was not achieved, statistically significant differences among the formulations demonstrate the impact of polymer matrices and tablet design on controlled drug delivery. The book provides valuable insights for students, researchers, and pharmaceutical scientists interested in modified-release dosage forms and formulation development. 76 pp. Englisch. …