Klebe Gerhard (51 results)
- Hardcover
Seller: medimops, Berlin, Germanymedimops
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Condition: good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present.
- Hardcover
Seller: medimops, Berlin, Germanymedimops
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£ 25.76
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Condition: very good. Gut/Very good: Buch bzw. Schutzumschlag mit wenigen Gebrauchsspuren an Einband, Schutzumschlag oder Seiten. / Describes a book or dust jacket that does show some signs of wear on either the binding, dust jacket or pages.
Language: English
Published by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin 2025
- Hardcover
Seller: Grand Eagle Retail, Bensenville, U.S.A.Grand Eagle Retail
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£ 85.06
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Hardcover. Condition: new. Hardcover. This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in…the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
- Hardcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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£ 64.99
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Hardcover. Condition: Brand New. 714 pages. 10.98x8.26x11.22 inches. In Stock.
- Hardcover
Seller: Books Puddle, New York, U.S.A.Books Puddle
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Condition: New. 2024th edition NO-PA16APR2015-KAP.
Language: English
Published by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin 2025
- Hardcover
Seller: CitiRetail, Stevenage, United KingdomCitiRetail
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£ 68.49
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Hardcover. Condition: new. Hardcover. This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in…the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
- Hardcover
Seller: Buchpark, Trebbin, GermanyBuchpark
Contact seller5-star sellerCondition: Used - Fine
£ 34.29
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 295 | Sprache: Englisch | Produktart: Bücher | In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by… means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
Contact seller5-star sellerCondition: New
£ 76.41
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structur…al biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet.
Language: English
Published by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin 2025
- Hardcover
Seller: AussieBookSeller, Truganina, AustraliaAussieBookSeller
Contact seller5-star sellerCondition: New
£ 126.23
£ 27.52 shippingShips from Australia to U.S.A.Quantity: 1 available
Hardcover. Condition: new. Hardcover. This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in…the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.
- Hardcover
Seller: California Books, Miami, U.S.A.California Books
Contact seller4-star sellerCondition: New
£ 154.75
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Condition: New.
- Hardcover
Seller: Ria Christie Collections, Uxbridge, United KingdomRia Christie Collections
Contact seller5-star sellerCondition: New
£ 137.84
£ 11.98 shippingShips from United Kingdom to U.S.A.Quantity: Over 20 available
Condition: New. In.
- Hardcover
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, IrelandKennys Bookshop and Art Galleries Ltd.
Contact seller5-star sellerCondition: New
£ 176.53
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Condition: New. The first workshop on new approaches in drug design and discovery was held in March 1999, at Schloss Rauischholzhausen, near Marburg in Germany. The speakers were invited to summarize their contributions together with their impressions on the applicability of their approach. This title summerizes this request. Ed…itor(s): Klebe, Gerhard. Num Pages: 295 pages, 35 black & white illustrations, 18 colour illustrations, biography. BIC Classification: MJA; MMG; TDCW. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 19. Weight in Grams: 688. . 2000. Reprinted from perspectives in drug discovery and. Hardback. . . . .
- Softcover
Seller: preigu, Osnabrück, Germanypreigu
Contact seller5-star sellerCondition: New
£ 124.98
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Taschenbuch. Condition: Neu. Virtual Screening: An Alternative or Complement to High Throughput Screening? | Proceedings of the Workshop 'New Approaches in Drug Design and Discovery', Special Topic 'Virtual Screening', Schloß Rauischholzhausen, Germany, March 15-18, 1999 | Gerhard Klebe | Taschenbuch | xi | Englisch | 2010 | Spr…inger | EAN 9789048155842 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
- Hardcover
Seller: moluna, Greven, Germanymoluna
Contact seller5-star sellerCondition: New
£ 161.10
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Condition: New. In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful .
- Softcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
Contact seller5-star sellerCondition: New
£ 150.63
£ 54.07 shippingShips from Germany to U.S.A.Quantity: 1 available
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powe…rful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Softcover
Seller: Books Puddle, New York, U.S.A.Books Puddle
Contact seller4-star sellerCondition: New
£ 204.31
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Condition: New. pp. 308.
- Hardcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
Contact seller5-star sellerCondition: New
£ 197.34
£ 12.50 shippingShips from United Kingdom to U.S.A.Quantity: 2 available
Hardcover. Condition: Brand New. 295 pages. 9.75x6.75x0.75 inches. In Stock.
- Hardcover
Seller: Kennys Bookstore, Olney, U.S.A.Kennys Bookstore
Contact seller5-star sellerCondition: New
£ 212.93
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Condition: New. The first workshop on new approaches in drug design and discovery was held in March 1999, at Schloss Rauischholzhausen, near Marburg in Germany. The speakers were invited to summarize their contributions together with their impressions on the applicability of their approach. This title summerizes this request. Ed…itor(s): Klebe, Gerhard. Num Pages: 295 pages, 35 black & white illustrations, 18 colour illustrations, biography. BIC Classification: MJA; MMG; TDCW. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 19. Weight in Grams: 688. . 2000. Reprinted from perspectives in drug discovery and. Hardback. . . . . Books ship from the US and Ireland.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
Contact seller5-star sellerCondition: New
£ 198.78
£ 55.00 shippingShips from Germany to U.S.A.Quantity: 1 available
Buch. Condition: Neu. Neuware - In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene va…riants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Hardcover
Seller: Mispah books, Redhill, United KingdomMispah books
Contact seller4-star sellerCondition: Used - As new
£ 225.00
£ 25.00 shippingShips from United Kingdom to U.S.A.Quantity: 1 available
hardcover. Condition: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.
- Hardcover
Seller: Mispah books, Redhill, United KingdomMispah books
Contact seller4-star sellerCondition: Used - As new
£ 229.00
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Hardcover. Condition: Like New. Like New. book.
- Hardcover
Seller: Mispah books, Redhill, United KingdomMispah books
Contact seller4-star sellerCondition: Used - As new
£ 714.00
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Hardcover. Condition: Like New. Like New. book.
- Hardcover
Seller: PAPER CAVALIER UK, London, United KingdomPAPER CAVALIER UK
Contact seller4-star sellerCondition: Used - Very good
£ 580.79
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Condition: very good. Gently used. May include previous owner's signature or bookplate on the front endpaper, sticker on back and/or remainder mark on text block.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
Contact seller5-star sellerCondition: New
£ 859.69
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Unique work on structure-based drug design, covering multiple aspects of drug discovery and development Fully colored, many images, computer animations of 3D structures (these only in electronic form) Makes the spatial aspects of interacting molecules cle…ar to the reader, covers multiple applications and methods in drug design Structures by mode of action, no therapeutic areas Of high relevance for academia and industrial research Focus on- gene technology in drug design, omics-technologies- computational methods- experimental techniques of structure determination- multiple examples on mode of action of current drugs- ADME-tox properties in drug development- QSAR methods- combinatorial chemistry- biologicals, ribosome, targeting protein-protein interfaces.
Language: German
Published by Heidelberg ; Berlin ; Oxford : Spektrum, Akad. Verl. 1996
- Softcover
Seller: Antiquariat Mäander Quell, Waldshut-Tiengen, GermanyAntiquariat Mäander Quell
Contact seller5-star sellerCondition: Used - Good
£ 8.12
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kart. Condition: Befriedigend. XXII, 599 S. ; 25 cm Buch mit deutlichen Gebrauchsspuren. Markierungen oder Eintragungen vorhanden. - Wir versenden aus unserem deutschen Lager heraus in plastikfreien oder wiederverwendeten Polstertaschen. Sprache: Deutsch Gewicht in Gramm: 1427.
- Hardcover
Seller: medimops, Berlin, Germanymedimops
Contact seller5-star sellerCondition: Used - As new
£ 62.13
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Condition: as new. Wie neu/Like new.
Language: German
Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Feb 2024 2024
- Hardcover
Seller: Rheinberg-Buch Andreas Meier eK, Bergisch Gladbach, GermanyRheinberg-Buch Andreas Meier eK
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£ 71.41
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Buch. Condition: Neu. Neuware -Die vorliegende 3. Auflage bringt das Thema Wirkstoffdesign wieder auf den aktuellen Stand der Forschung. Der Leser lernt neue Methoden in der Gentechnologie und die erweiterte Palette strukturbiologischer Verfahren kennen. Gerade die letzten 10 Jahre wurden durch Einsatz dieser Methoden viele komp…lexe Zielstrukturen wie die G-Protein gekoppelten Rezeptoren oder Ionenkanälen aufgeklärt. Der Leser erfährt wie diese lange ersehnten Komplexstrukturen mit klassischen Arzneistoffen aussehen und wie die therapeutische Wirkung erzielt wird. Im Wirkstoffdesign ist die räumliche Struktur der interagierenden Moleküle von zentraler Bedeutung. Hier liegt der Schlüssel, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Daher wurden die Farbabbildungen in der 3. Auflage neu gestaltet und mit Videos verknüpft, die direkt über QR-Codes neben den Abbildungen mit üblichen Handys oder Tablets ohne weitere Appaufgerufen werden. Die bewegten Moleküldarstellungen geben dem Leser einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen.Dieses Lehrbuch wurde ursprünglich von Hans-Joachim Böhm, Gerhard Klebe und Hugo Kubinyi begründet und richtet sich an Studierende der Pharmazie, Chemie und der Biowissenschaften, aber auch an Quereinsteiger und Medizinische Chemiker in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Es wurde mit dem Literaturpreis des Fonds der Chemischen Industrie ausgezeichnet. Konzeptionell hebt es sich sehr stark von klassischen Lehrbüchern der pharmazeutischen Chemie ab und rückt den Weg zum neuen Arzneistoff in den Mittelpunkt. Die Auswahl der Fallbeispiele erfolgte nach didaktischen Gesichtspunkten und versucht einen weiten Überblick über Methoden und Strategien zu geben ohne den Blick zurück auf die Anfänge dieses Arbeitsgebiet zu vergessen. So spannt sich der Bogen von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsverfahren, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design.In der 3. Auflage kommen neue Methoden und Konzepte wie die Epigenetik, der PROTAC-Ansatz, die CRISPR-Cas9-Genschere, Strukturvorhersagen aus der Sequenz, der Einsatz von Künstlicher Intelligenz und neue Screening-Technologien aus der Biophysik zur Sprache. Erfolge beim Stören bzw. Verstärken von Protein-Protein-Wechselwirkungen als Konzept der Arzneistofftherapie werden vorgestellt und Überlegungen zur Optimierung von Arzneistoffen unter Berücksichtigung ihrer thermodynamischen wie kinetischen Bindungsprofile werden diskutiert.Videos per App: einfach die SN More Media App kostenfrei herunterladen, einen Link mit dem Play-Button scannen und sofort das video auf Smartphone oder Tablet ausspiele. 796 pp. Deutsch.
Language: German
Published by Springer Fachmedien Wiesbaden, Weisbaden 2024
- Hardcover
Seller: Grand Eagle Retail, Bensenville, U.S.A.Grand Eagle Retail
Contact seller5-star sellerCondition: New
£ 88.30
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Hardcover. Condition: new. Hardcover. Die vorliegende 3. Auflage bringt das Thema Wirkstoffdesign wieder auf den aktuellen Stand der Forschung. Der Leser lernt neue Methoden in der Gentechnologie und die erweiterte Palette strukturbiologischer Verfahren kennen. Gerade die letzten 10 Jahre wurden durch Einsatz dieser Methoden vie…le komplexe Zielstrukturen wie die G-Protein gekoppelten Rezeptoren oder Ionenkanaelen aufgeklaert. Der Leser erfaehrt wie diese lange ersehnten Komplexstrukturen mit klassischen Arzneistoffen aussehen und wie die therapeutische Wirkung erzielt wird. Im Wirkstoffdesign ist die raeumliche Struktur der interagierenden Molekuele von zentraler Bedeutung. Hier liegt der Schluessel, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Daher wurden die Farbabbildungen in der 3. Auflage neu gestaltet und mit Videos verknuepft, die direkt ueber QR-Codes neben den Abbildungen mit ueblichen Handys oder Tablets ohne weitere Appaufgerufen werden. Die bewegten Molekueldarstellungen geben dem Leser einen leichten Zugang zum raeumlichen Verstaendnis der molekularen Strukturen und Interaktionen.Dieses Lehrbuch wurde urspruenglich von Hans-Joachim Boehm, Gerhard Klebe und Hugo Kubinyi begruendet und richtet sich an Studierende der Pharmazie, Chemie und der Biowissenschaften, aber auch an Quereinsteiger und Medizinische Chemiker in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Es wurde mit dem Literaturpreis des Fonds der Chemischen Industrie ausgezeichnet. Konzeptionell hebt es sich sehr stark von klassischen Lehrbuechern der pharmazeutischen Chemie ab und rueckt den Weg zum neuen Arzneistoff in den Mittelpunkt. Die Auswahl der Fallbeispiele erfolgte nach didaktischen Gesichtspunkten und versucht einen weiten UEberblick ueber Methoden und Strategien zu geben ohne den Blick zurueck auf die Anfaenge dieses Arbeitsgebiet zu vergessen. So spannt sich der Bogen von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung ueber Strukturbestimmungsverfahren, Modelling, Molekueldynamik und QSAR-Methoden bis zum struktur- und computergestuetzten Design.In der 3. Auflage kommen neue Methoden und Konzepte wie die Epigenetik, der PROTAC-Ansatz, die CRISPR-Cas9-Genschere, Strukturvorhersagen aus der Sequenz, der Einsatz von Kuenstlicher Intelligenz und neue Screening-Technologien aus der Biophysik zur Sprache. Erfolge beim Stoeren bzw. Verstaerken von Protein-Protein-Wechselwirkungen als Konzept der Arzneistofftherapie werden vorgestellt und UEberlegungen zur Optimierung von Arzneistoffen unter Beruecksichtigung ihrer thermodynamischen wie kinetischen Bindungsprofile werden diskutiert.Videos per App: einfach die SN More Media App kostenfrei herunterladen, einen Link mit dem Play-Button scannen und sofort das video auf Smartphone oder Tablet ausspiele. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Language: German
Published by Spektrum Akademischer Verlag Auflage: 2. Auflage. (April 2009) 2009
- Hardcover
Seller: BUCHSERVICE / ANTIQUARIAT Lars Lutzer, Wahlstedt, GermanyBUCHSERVICE / ANTIQUARIAT Lars Lutzer
Contact seller4-star sellerCondition: Used - Very good
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Hardcover. Condition: gut. Auflage: 2. Auflage. (April 2009). Dieses für den deutschen Raum einzigartige Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Die zweite Auflage ist komplett überarbeit…et. Zahlreiche aktuelle Entwicklungen vor allem im methodischen Bereich sind zum Teil in neuen Kapiteln aufgegriffen, viele Fallbeispiele machen die Theorien und Verfahren anschaulich und nachvollziehbar. Der Bogen spannt sich von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsmethoden, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design. Insgesamt legt das Buch besonderen Wert auf die räumliche Struktur der interagierenden Moleküle und erklärt, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Die beiliegende DVD mit interaktiven Molekülmodellen dient dem Ziel, dem Lernenden einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen zu geben. Autor: Gerhard Klebe ist Professor für Pharmazeutische Chemie an der Philipps-Universität Marburg. Seine Forschungsschwerpunkte sind Struktur-Aktivitätsbeziehungen, 3D-QSAR-Methoden, Konformations- und Pharmakophoranalysen, Dockingmethoden, Datenbankanalysen, Proteinkristallographie, strukturbasiertes Wirkstoffdesign und die biophysikalische Charakterisierung von Protein-Ligand-Wechselwirkungen. Vor seiner Berufung nach Marburg hat er an der Universität Heidelberg gelehrt und war im Hauptlaboratorium der BASF AG in Ludwigshafen im Bereich Wirkstoffdesign und Kristallographie tätig. Inhalt: Einführung.-Teil I Grundlagen der Arzneimittelforschung.-1 Arzneimittelforschung gestern, heute, morgen.-2 Am Anfang stand der glückliche Zufall.-3 Klassische Arzneimittelforschung.-4 Protein-Ligand-Wechselwirkungen als Grundlage der Arzneistoffwirkung.-5 Optische Aktivität und biologische Wirkung.-Teil II Die Suche nach der Leitstruktur.-6 Die klassische Suche nach der Leitstruktur.-7. Screening-Technologien zur Leitstruktursuche.-8 Die Optimierung der Leitstruktur.-9 Der Entwurf von Prodrugs.-10 Peptidomimetika.-Teil III Experimentelle und theoretische Methoden.-11 Kombinatorik: Chemie mit großen Zahlen.-12 Gentechnologie in Arzneimittelforschung.-13 Experimentelle Methoden der Strukturaufklärung.-14 Beschreibung der Struktur von Biomolekülen.-15 Molecular Modelling.-16 Konformationsanalyse.-Teil IV Quantitative Struktur-Wirkungsbeziehungen und Design-Methoden.-17 Pharmakophorhypothesen, Molekülvergleiche und Datenbanksuchen.-18 Quantitative Struktur-Wirkungsbeziehungen.-19 Von in vitro zu in vivo: Optimierung von ADME-Tox Eigenschaften.-20 Proteinmodellierung und strukturbasiertes Wirkstoffdesign.-21 Ein Beispiel: Strukturbasiertes Design von Inhibitoren der tRNA-Guanintransglycosylase.-Teil V Erfolge beim rationalen Design von Wirkstoffen.-22 Wie wirken Arzneistoffe: Angriffspunkte für eine Therapie.-23 Inhibitoren für Hydrolasen mit Acylenzym-Zwischenstufe.-24 Aspartylprotease-Inhibitoren.-25 Inhibitoren von hydrolytisch-spaltenden Metalloenzymen.-26 Hemmstoffe für Transferasen.-27 Hemmstoffe für Oxidoreduktasen.-28 Agonisten und Antagonisten für nucleäre Rezeptoren.-29. Agonisten und Antagonisten von membranständige Rezeptoren.-30 Liganden für Kanäle, Poren und Transporter.-31 Liganden für Oberflächenrezeptoren.-32 Biopharmaka: Peptide, Proteine, Nucleotide und Makrolide als Wirkstoffe Wirkstoffdesign Entwurf und Wirkung von Arzneistoffen Gerhard Klebe Wirkstoffe Pharmakologie Arzneimittelchemie Pharmaka Arzneimittellehre Tablette Arznei Arzneimittel Medikament Zusatzinfo XXI, 637 S. Mit DVD. Verlagsort Heidelberg Sprache deutsch Maße 203 x 276 mm Medizin Pharmazie Pharmakologie Naturwissenschaften Chemie 3D-Struktur Arzneimittel Arzneimittelchemie Biomolekül drug design Medikamentenentwicklung Medizinische Chemie Nucleotide Pharmazeutische Chemie Pharmazeutike Proteine Transport Wechselwirkung Wirkstoffdesign Wirkstoffe ISBN-10 3-8274-2046-6 / 3827420466 ISBN-13 978-3-8274-2046-6 / 9783827420466 In deutscher Sprache. 634 pages. 26,4 x 20 x 3,2 cm.
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Condition: New. Einziges deutschsprachiges Lehrbuch zum Thema WirkstoffentwicklungVideos von interaktiven Molekuelmodellen zur besseren 3D-Visualisierung ueber QR-Code Topaktuell, gegenueber der 2. Auflage komplett ueberarbeitet und erweitertSehr gu.
