Drug Design : From Structure and Mode-of-Action to Rational Design Concepts
Language: English
Published by Springer Gabler, 2025
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 85.02
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Add to basketItem description from seller
Druck auf Anfrage Neuware - Printed after ordering - This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet.…
Seller Inventory # 9783662689974
- Title
- Drug Design : From Structure and Mode-of-Action to Rational Design Concepts
- Author
- Gerhard Klebe
- Publisher
- Springer Gabler
- Publication year
- 2025
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 3662689979
- ISBN 13
- 9783662689974
- Item weight
- 2,096 grams
- Dimensions
- 285x215x42 mm
This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.
This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.
This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .
Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet.
"Synopsis" may belong to another edition of this title.
About the Author
Gerhard Klebe is Professor of Pharmaceutical Chemistry at Philipps-Universität Marburg. He retired in April 2020. His research focuses on structure-activity relationships, 3D-QSAR methods, conformational and pharmacophore analyses, docking methods, database analyses, protein crystallography, structure-based drug design and the biophysical characterisation of protein-ligand interactions. Before his appointment in Marburg, he taught at the University of Heidelberg and worked in the main laboratory of BASF AG in Ludwigshafen in the field of drug design and crystallography.
"About the title" may belong to another edition of this title.
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