Physiologically Based Pharmacokinetic Modeling (96 results)
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Paperback or Softback. Condition: New. Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling. Book.
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Published by LAP Lambert Academic Publishing 2009-08-26 2009
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Condition: New. KlappentextrnrnA physiologically - based pharmacokinetic model has been developed to examine the effects of organophosphates on the levels of acetylcholine in different tissues throughout the mammalian body. Many organophosphate-like chemical an.
Physiologically Based Pharmacokinetic Modeling : Science and Applications
Reddy, Micaela; Yang, R. S.; Andersen, Melvin E.; Clewell III, Harvey J.
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
Reddy, Micaela; Yang, R. S.; Andersen, Melvin E.; Clewell III, Harvey J.
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Physiologically Based Pharmacokinetic Modeling : Science and Applications
Reddy, Micaela,Yang, R. S.,Andersen, Melvin E.,Clewell III, Harvey J.
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Taschenbuch. Condition: Neu. Neuware - Novel properties of engineered nanoparticles that make them attractive may also present unique exposure risks. The traditional physiologically-based pharmacokinetic (PBPK) modeling assumption of instantaneous equilibration likely does not apply to nanoparticles. This simulation-based resear…ch begins with development of a model that includes di usion, active transport, and carrier mediated transport. Eigenvalue analysis was used to examine model behavior to focus future research. Results show that cellular transport processes greatly a ect biokinetics of nanoparticles. The new paradigm established by this research leverages traditional in vitro, in vivo, and PBPK modeling, but includes area under the curve to bridge animal testing results to humans. This allows assessment of risk and assists in setting appropriate exposure limits. The model provides critical understanding of nanoparticle biokinetics and allows estimation of total exposure. This e ort highlights future research needs and demonstrates how modeling can be used as a tool to advance nanoparticle risk assessment.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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Published by British Library, Historical Print Editions Nov 2012 2012
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Taschenbuch. Condition: Neu. Neuware - A physiologically - based pharmacokinetic model has been developed to examine the effects of organophosphates on the levels of acetylcholine in different tissues throughout the mammalian body. Many organophosphate-like chemical and kinetic characteristics are tested without reference to a s…pecific chemical. Characteristics include partition coefficients, metabolic constants, the inhibition coefficient, the aging rate, and the regeneration rate. Two separate exposure scenarios are tested and compared against a baseline. The baseline consists of a direct inhalation exposure. The first exposure scenario examines the effects of bronchial scrubbing (via inhalation) and the second scenario is a study of dermal exposures and compares the levels of ACh in the different tissues with those in the inhalation (baseline) tests. Organophosphates that are absorbed directly into the bronchial tissue exhibit little variation on the levels of ACh buildup in any of the tissue groups tested when compared to the inhalation exposures. No matter what the scrubbing coefficient used, or the combination of the parameters (partition coefficients, inhibition coefficient, aging rate, and regeneration rate) values, the change in ACh was minimal. The results showed different behavior between inhalation and dermal exposures. The dermal results suggest that an individual may have additional time to don protective equipment before the levels of ACh are high enough to render the person incapable of doing so.
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Buch. Condition: Neu. Neuware - Novel properties of engineered nanoparticles that make them attractive may also present unique exposure risks. The traditional physiologically-based pharmacokinetic (PBPK) modeling assumption of instantaneous equilibration likely does not apply to nanoparticles. This simulation-based research begi…ns with development of a model that includes di usion, active transport, and carrier mediated transport. Eigenvalue analysis was used to examine model behavior to focus future research. Results show that cellular transport processes greatly a ect biokinetics of nanoparticles. The new paradigm established by this research leverages traditional in vitro, in vivo, and PBPK modeling, but includes area under the curve to bridge animal testing results to humans. This allows assessment of risk and assists in setting appropriate exposure limits. The model provides critical understanding of nanoparticle biokinetics and allows estimation of total exposure. This e ort highlights future research needs and demonstrates how modeling can be used as a tool to advance nanoparticle risk assessment.
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Condition: Good. Good; Hardcover; Covers are moderately shelfworn and edgeworn; Unblemished textblock edges; The endpapers and all text pages are clean and unmarked; Good binding; This book will be stored and delivered in a sturdy cardboard box with foam padding; Medium Format (8.5" - 9.75" tall); Dark blue and red covers with t…itle in white lettering; 2005, Wiley-Interscience Publishing; 420 pages; "Physiologically Based Pharmacokinetic Modeling : Science and Applications," by Micaela Reddy, et al.
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Taschenbuch. Condition: Neu. Physiologically Based Pharmacokinetic Modeling | Of Monoclonal Antibodies | Jasmine Davda | Taschenbuch | 112 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838309705 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademik…erverlag[dot]de | Anbieter: preigu.
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Published by British Library, Historical Print Editions 2012
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Physiologically Based Pharmacokinetic Modeling : Science And Applications
Reddy, Micaela B. (EDT); Yang, Raymond S. H., Ph.D. (EDT); Clewell, Harvey J., III (EDT); Andersen, Melvin E., Ph.D. (EDT)
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