Lange Robert C (66 results)

Hardcover. Condition: Used - Very Good. A revealing look at the changing face of the American landscape, from the 1850s to today, as depicted by some of America's greatest photographers. 150 photographs provide a fascinating view of our land, juxtaposing what it once looked like with what it is today. Very nice clean, tight copy free of any marks. Wrapped in complimentary Brodart dust jacket protector.

Hardcover/Pappeinband. Condition: Sehr gut. 228 p. Very good. Shrink wrapped. / Sehr guter Zustand. In Folie verschweißt. Sprache: Englisch Gewicht in Gramm: 550.

Hardcover. Condition: Very Good. Gently used, if at all. Binding is tight, corners are sharp and there are no markings. Pasadena's finest new and used bookstore since 1992.

Wraps. Condition: Fair. Pages 887-897, [1] pages. Tables. References. Hole through several pages. Stamp and ink notations on front page. During the medical surveys of adult atomic bomb survivors carried out in the Atomic Bomb Casualty Commission Clinic in Hiroshima, nine cased of leukemia were encountered. An account of these cases is presented in this report. William Curry Moloney, MD, who studied and treated blood diseases before hematology became a medical specialty, was a professor emeritus of medicine at Harvard Medical School and former director of hematology at Brigham and Women's Hospital. He was one of the first hematologists to use chemotherapy to treat leukemia and lymphoma. Dr. Moloney was also an early contributor to the development of specific diagnostic tests, some of which are still in use today. Dr. Moloney was a recognized authority on safe procedures for blood transfusions, and his expertise in blood banks stood him in good stead in World War II, when he oversaw transfusions to wounded soldiers. After the war, in the early 1950s, Dr. Moloney directed research for the Atomic Bomb Casualty Commission in Hiroshima, Japan. Later, in the Marshall Islands, he studied the effects of errant radiation and the mechanisms that produce leukemia. Robert Dale Lange received a BS from Macalester College at St. Paul, Minn., in 1941, and an M. D. from Washington University's School of Medicine at St. Louis, Missouri, in 1944. He was a major in the U. S. Army and served on the Atomic Bomb Casualty Commission at Hiroshima from 1951-1953. In 1964, Lange to Knoxville, Tennessee, to work for the University of Tennessee Memorial Research Center and Hospital (UTMRCH), where he rose to the rank of director. Lange became professor and chairman in the Department of Medical Biology by 1978. From 1969 to 1993 as a representative of UT, he acted as a member of their Human Subjects Committee. In 1985, Dr. Lange retired; but as a professor emeritus and practicing doctor, he continued his work in hematology. As investigator on several NASA experiments, he enabled UT's medical projects fly on the space shuttles in the late 1980s and early 1990s, including Challenger's ill-fated mission of 1986. Lange's professional career also includes over 150 journal papers and book chapters, as well as a tremendous number of reviews and abstracts. He was a Fellow of the American College of Physicians and of the International Society of Hematology and a member of many national and international societies and organizations, including Sigma XI and Pi Phi Epsilon. Reprinted from Texas Reports on Biology and Medicine, Volume 12, Number 4, pages 887-897, Winter 1954.

Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condition: Used. pp. 240 1st Edition.

Condition: Used. pp. 240.

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Hardcover. Condition: New. Brand new. Excellent customer service.

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Hardcover. Condition: new. Hardcover. The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the bloodbrain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Condition: New.

Condition: As New. Unread book in perfect condition.

Condition: As New. Unread book in perfect condition.

Condition: New. pp. 751 Softcover reprint of the original 1st ed. 2014 edition NO-PA16APR2015-KAP.

Taschenbuch. Condition: Neu. Drug Delivery to the Brain | Physiological Concepts, Methodologies and Approaches | Margareta Hammarlund-Udenaes (u. a.) | Taschenbuch | xx | Englisch | 2016 | Springer US | EAN 9781493943661 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condition: Neu. Drug Delivery to the Brain | Physiological Concepts, Methodologies and Approaches | Elizabeth C. M. De Lange (u. a.) | Taschenbuch | AAPS Advances in the Pharmaceutical Sciences Series | xxi | Englisch | 2023 | Springer | EAN 9783030887759 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Condition: Sehr gut. Zustand: Sehr gut | Seiten: 828 | Sprache: Englisch | Produktart: Bücher | The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the bloodżbrain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Condition: New.

Condition: New.

Condition: New.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood -brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Condition: As New. Unread book in perfect condition.

Condition: New. pp. 806.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few.Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding ofthe many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiologicalconsiderations writtenspecifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Condition: As New. Unread book in perfect condition.

Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few.Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding ofthe many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiologicalconsiderations writtenspecifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.