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Hardback. Condition: New. 1st. Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power?Can standard inferential tests be applied following response-adaptive randomization?What is the effect of delayed response?Which procedure is most appropriate and how can "most appropriate" be quantified?How can heterogeneity of the patient population be incorporated?Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomizationThe general result for determining asymptotically best proceduresProcedures based on urn modelsProcedures based on sequential estimationImplications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.…

Condition: New. pp. xiii + 218 Illus.

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Condition: Used. pp. ix + 385.

Condition: New. In this well written book, the authors treat the fundamental question of response-adaptive randomization as dealing with the trade-off between minimizing the expected number of treatment failures and maximizing the power of inferential tests. Series: Wiley Series in Probability and Statistics. Num Pages: 232 pages, Illustrations. BIC Classification: MB; PB. Category: (P) Professional & Vocational. Dimension: 243 x 166 x 19. Weight in Grams: 488. . 2006. 1st Edition. Hardcover. . . . .…

hardcover. Condition: New. In shrink wrap. Looks like an interesting title.

Condition: Used. pp. ix + 385.

Hardcover. Condition: Brand New. 1st edition. 218 pages. 9.50x6.25x0.75 inches. In Stock.

Condition: Used. pp. ix + 385.

Condition: New. In this well written book, the authors treat the fundamental question of response-adaptive randomization as dealing with the trade-off between minimizing the expected number of treatment failures and maximizing the power of inferential tests. Series: Wiley Series in Probability and Statistics. Num Pages: 232 pages, Illustrations. BIC Classification: MB; PB. Category: (P) Professional & Vocational. Dimension: 243 x 166 x 19. Weight in Grams: 488. . 2006. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.…

Hardback. Condition: New. 1st. Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power?Can standard inferential tests be applied following response-adaptive randomization?What is the effect of delayed response?Which procedure is most appropriate and how can "most appropriate" be quantified?How can heterogeneity of the patient population be incorporated?Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomizationThe general result for determining asymptotically best proceduresProcedures based on urn modelsProcedures based on sequential estimationImplications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.…

Hardback. Condition: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days 518.

Hardcover. Condition: new. Hardcover. Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power?Can standard inferential tests be applied following response-adaptive randomization?What is the effect of delayed response?Which procedure is most appropriate and how can "most appropriate" be quantified?How can heterogeneity of the patient population be incorporated?Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomizationThe general result for determining asymptotically best proceduresProcedures based on urn modelsProcedures based on sequential estimationImplications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice. In this well written book, the authors treat the fundamental question of response-adaptive randomization as dealing with the trade-off between minimizing the expected number of treatment failures and maximizing the power of inferential tests. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.…

Hardcover. Condition: Brand New. 1st edition. 218 pages. 9.50x6.25x0.75 inches. In Stock. This item is printed on demand.

Condition: New. PRINT ON DEMAND pp. xiii + 218.