The Theory of Response-Adaptive Randomization in Clinical Trials
Feifang Hu
Sold by Kennys Bookstore, Olney, MD, U.S.A.
AbeBooks Seller since 9 October 2009
New - Hardcover
Condition: New
Ships within U.S.A.
Quantity: Over 20 available
Add to basketSold by Kennys Bookstore, Olney, MD, U.S.A.
AbeBooks Seller since 9 October 2009
Condition: New
Quantity: Over 20 available
Add to basketIn this well written book, the authors treat the fundamental question of response-adaptive randomization as dealing with the trade-off between minimizing the expected number of treatment failures and maximizing the power of inferential tests. Series: Wiley Series in Probability and Statistics. Num Pages: 232 pages, Illustrations. BIC Classification: MB; PB. Category: (P) Professional & Vocational. Dimension: 243 x 166 x 19. Weight in Grams: 488. . 2006. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.
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The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.
This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:
The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:
Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.
WILLIAM F. ROSENBERGER, PhD, is Professor and Chair of the Department of Applied and Engineering Statistics at George Mason University. He received the Association of American Publishers' Professional/Scholarly Publishing Award in 2002 for his coauthored work, Randomization in Clinical Trials: Theory And Practice (Wiley). A Fellow of the American Statistical Association, he has authored over fifty refereed articles and edited two monographs.
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