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  • Language: English

    Published by Springer, 1989

    0306426374 / 9780306426377

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    Condition: very_good. Gently read. May have name of previous ownership, or ex-library edition. Binding tight; spine straight and smooth, with no creasing; covers clean and crisp. Minimal signs of handling or shelving. 100% GUARANTEE! Shipped with delivery confirmation, if you're not satisfied with purchase please return item! Ships USPS Media Mail.…

  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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    Condition: New. pp. 438.

  • Language: English

    Published by Springer US, 2011

    1461280397 / 9781461280392

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    Paperback. Condition: Brand New. 434 pages. 9.60x6.69x0.99 inches. In Stock.

  • Language: English

    Published by Springer US, 2011

    1461280397 / 9781461280392

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  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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    Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled 'Facilitated transfer of glucose from blood to brain tissue. ' This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled 'Fine structural localization of a blood-brain barrier to exogenous peroxidase,' sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions.…

  • Language: English

    Published by Springer, 1989

    0306426374 / 9780306426377

    • Hardcover

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    Condition: Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.…

  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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    Taschenbuch. Condition: Neu. Implications of the Blood-Brain Barrier and Its Manipulation | Volume 1 Basic Science Aspects | E. A. Neuwelt | Taschenbuch | 434 S. | Englisch | 2011 | Springer | EAN 9781461280392 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by SPRINGER, 1989

    0306426285 / 9780306426285

    • Hardcover
    • International Edition

    Seller: UK BOOKS STORE, London, LONDO, United KingdomUK BOOKS STORE

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    Condition: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

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    Language: English

    Published by Humana, 2012

    1461572576 / 9781461572572

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    Taschenbuch. Condition: Neu. Implications of the Blood-Brain Barrier and Its Manipulation | Volume 2 Clinical Aspects | E. A. Neuwelt | Taschenbuch | 668 S. | Englisch | 2012 | Humana | EAN 9781461572572 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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    Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - As a neurologist and student of the microvasculature, I find great pleasure in introducing this treatise. Presented here is a view of brain pathophysiology and therapy from the perspective of the blood-brain barrier (BBB). Virtually every disease process that affects the brain-traumatic, neoplastic, infectious, inflammatory, toxic, metabolic, degenera tive, vascular, and epileptic-affects the BBB. Damage to this homeostatic system often leads to disruption of the composition and volume of brain fluid compartments, thereby contributing to neurologic symptoms and pathology. Furthermore, in disorders in which the integrity of the barrier is not breached, its normal restrictive nature may limit therapeu tic approaches. For example, the barrier appears to function normally in Parkinson dis ease, but its ability to compensate for striatal dopamine depletion is in part determined by the activity of transporters and enzymes operative in the brain microvasculature. of antibiotics, anticonvulsants, antineoplastic agents, and neurolep Similarly, the choice tics requires attention to these drugs' interaction with the BBB. Thus, the barrier inter faces with virtually all nervous system diseases and therapies. Future brain treatments with regulatory peptides, immune mediators, and gene components will require selective methods to deliver these agents to specific brain regions. The second volume of this text successfully provides a thorough review of BBB function and failure in a variety of clinical situations.…

  • Language: English

    Published by Springer, 1989

    0306426374 / 9780306426377

    • Hardcover

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  • Language: English

    Published by Kluwer Academic Publishers Group, 1989

    0306426374 / 9780306426377

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    Condition: Sehr gut. Zustand: Sehr gut | Seiten: 668 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by Springer, 2012

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    Paperback. Condition: Brand New. reprint edition. 668 pages. 9.80x7.00x1.50 inches. In Stock.

  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by Springer, 2012

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  • Language: English

    Published by Springer, 2012

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  • Language: English

    Published by Kluwer Academic Publishers Group, 1989

    0306426374 / 9780306426377

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    Hardcover. Condition: gut. 1989. Implications of the Blood-Brain Barrier and Its Manipulation In englischer Sprache. pages.

  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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  • Language: English

    Published by Springer 2011-10, 2011

    1461280397 / 9781461280392

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    PF. Condition: New. This item is printed on demand. Brand new book, sourced directly from publisher. Dispatch time is 6-7 days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

  • Language: English

    Published by Springer US Okt 2011, 2011

    1461280397 / 9781461280392

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    Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled 'Facilitated transfer of glucose from blood to brain tissue. ' This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled 'Fine structural localization of a blood-brain barrier to exogenous peroxidase,' sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions. 436 pp. Englisch.…

  • Language: English

    Published by Springer, 2012

    1461572576 / 9781461572572

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  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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    Condition: New. Print on Demand pp. 438 67:B&W 6.69 x 9.61 in or 244 x 170 mm (Pinched Crown) Perfect Bound on White w/Gloss Lam.

  • Language: English

    Published by Springer, 2011

    1461280397 / 9781461280392

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    Condition: New. PRINT ON DEMAND pp. 438.

  • Language: English

    Published by Springer US, Springer Okt 2011, 2011

    1461280397 / 9781461280392

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    Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled 'Facilitated transfer of glucose from blood to brain tissue. ' This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled 'Fine structural localization of a blood-brain barrier to exogenous peroxidase,' sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.…

  • Language: English

    Published by Springer US Aug 2012, 2012

    1461572576 / 9781461572572

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    Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As a neurologist and student of the microvasculature, I find great pleasure in introducing this treatise. Presented here is a view of brain pathophysiology and therapy from the perspective of the blood-brain barrier (BBB). Virtually every disease process that affects the brain-traumatic, neoplastic, infectious, inflammatory, toxic, metabolic, degenera tive, vascular, and epileptic-affects the BBB. Damage to this homeostatic system often leads to disruption of the composition and volume of brain fluid compartments, thereby contributing to neurologic symptoms and pathology. Furthermore, in disorders in which the integrity of the barrier is not breached, its normal restrictive nature may limit therapeu tic approaches. For example, the barrier appears to function normally in Parkinson dis ease, but its ability to compensate for striatal dopamine depletion is in part determined by the activity of transporters and enzymes operative in the brain microvasculature. of antibiotics, anticonvulsants, antineoplastic agents, and neurolep Similarly, the choice tics requires attention to these drugs' interaction with the BBB. Thus, the barrier inter faces with virtually all nervous system diseases and therapies. Future brain treatments with regulatory peptides, immune mediators, and gene components will require selective methods to deliver these agents to specific brain regions. The second volume of this text successfully provides a thorough review of BBB function and failure in a variety of clinical situations. 668 pp. Englisch.…

  • Language: English

    Published by Springer US, 2012

    1461572576 / 9781461572572

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    Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. As a neurologist and student of the microvasculature, I find great pleasure in introducing this treatise. Presented here is a view of brain pathophysiology and therapy from the perspective of the blood-brain barrier (BBB). Virtually every disease process th.…