Douroumis Dennis (51 results)

Hardcover. Condition: Good. 1st Edition. Hardcover, xviii + 364 pages, NOT ex-library. Good condition, limited wear. Interior is clean and bright with unmarked text, firmly bound. Blank stickers inside the front board; neatly removed title page. Issued without a dust jacket. -- Contents [each chapter comes with an Introduction & Summary & References]: 1. Single-screw Extrusion: Principles / Keith Luker [Ideal Compounding; Basics of the Single-screw Extruder; SSE Elongational Mixers] 2. Twin-screw Extruders for Pharmaceutical Hot-melt Extrusion: Technology, Techniques and Practices / Dirk Leister [Extruder Types and Working Principle; Individual Parts of a TSE; Downstreaming; Individual Processing Sections of the TSE; Feeding of Solids; TSE Operating Parameters; Setting up an HME Process using QbD Principles] 3. Hot-melt Extrusion Developments in the Pharmaceutical Industry / Ana Almeida [Advantages of HME as Drug Delivery Technology; Formulations used for HME Applications; Characterization of Extrudates; Hot-melt Extruded Dosage Forms; A View to the Future] 4. Solubility Parameters for Prediction of Drug/Polymer Miscibility in Hot-melt Extruded Formulations / Andreas Gryczke [Solid Dispersions; Basic Assumptions for the Drug-polymer Miscibility Prediction; Solubility and the Flory-Huggins Theory; Miscibility Estimation of Drug and Monomers] 5. The Influence of Plasticizers in Hot-melt Extrusion / Geert Verreck [Traditional & Non-traditional & Specialty Plasticizers] 6. Applications of Poly(meth)acrylate Polymers in Melt Extrusion / Kathrin Nollenberger [Polymer Characteristics; Melt Extrusion of Poly(methacrylates) to Design Pharmaceutical Oral Dosage Forms; Solubility Enhancement; Bioavailability Enhancement of BCS Class IV Drugs] 7. Hot-melt Extrusion of Ethylcellulose, Hypromellose and Polyethylene Oxide / Mark Hall [Background; Thermal Properties; Processing Aids/Additives; Unconventional Processing Aids: Drugs, Blends; Case Studies; Milling of EC, HPMC and PEO Extrudate] 8. Bioadhesion Properties of Polymeric Films Produced by Hot-melt Extrusion / Joshua Boateng [Anatomy of the Oral Cavity and Modes of Drug Transport; Mucoadhesive Mechanisms; Factors Affecting Mucoadhesion in the Oral Cavity; Determination of Mucoadhesion and Mechanical Properties of Films; Bioadhesive Films Prepared by HME] 9. Taste Masking Using Hot-melt Extrusion / Dennis Douroumis [Need and Challenges for Masking Bitter APIs; Organization of the Taste System; Taste Sensing Systems (Electronic Tongues) for Pharmaceutical Dosage Forms; Hot-melt Extrusion: An Effective Means of Taste Masking] 10. Clinical and Preclinical Studies, Bioavailability and Pharmacokinetics of Hot-melt Extruded Products / Sandra Guns [Introduction to Oral Absorption; In Vivo Evaluation of Hot-melt Extruded Solid Dispersions] 11. Injection Molding and Hot-melt Extrusion Processing for Pharmaceutical Materials / Pernille Hoyrup Hemmingsen [Hot-melt Extrusion in Brief; Injection Molding; Critical Parameters; Example: Comparison of Extruded & Injection-molded Material; Development of Products for Injection Molding; Properties of Injection-molded Materials] 12. Laminar Dispersive & Distributive Mixing with Dissolution and Applications to Hot-melt Extrusion / Costas G. Gogos [Elementary Steps in HME; Dispersive & Distributive Mixing; HME Processes: Cases I & II; Dissolution of Drug Particulates in Polymeric Melt; Case Study: Acetaminophen & Poly(ethylene oxide); Determination of Solubility of APAP in PEO] 13. Technological Considerations Related to Scale-up of Hot-melt Extrusion Processes / Adam Dreiblatt [Scale-up Terminology; Volumetric & Power & Heat Transfer & Die Scale-up] 14. Devices & Implant Systems by Hot-melt Extrusion / Andrew Loxley 15. Hot-melt Extrusion: An FDA Perspective on Product and Process Understanding / Abhay Gupta [Quality by Design; Utilizing QbD for HME Process Understanding] 16. Improved Process Understanding and Control of a Hot-melt Extrusion Process with Near-Infrared Spectroscopy / Chris Heil.…

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Condition: New. Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Series: Advances in Pharmaceutical Technology. Num Pages: 382 pages, Illustrations. BIC Classification: TDCB; TDCW. Category: (P) Professional & Vocational. Dimension: 254 x 175 x 23. Weight in Grams: 754. . 2012. 1st Edition. hardcover. . . . .…

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Hardback. Condition: New. Hot-melt extrusion (HME)  - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusiontwin screw extrusion techniques and practices in the laboratory and on production scaleHME developments for the pharmaceutical industrysolubility parameters for prediction of drug/polymer miscibility in HME formulationsthe influence of plasticizers in HMEapplications of polymethacrylate polymers in HMEHME of ethylcellulose, hypromellose, and polyethylene oxidebioadhesion properties of polymeric films produced by HMEtaste masking using HMEclinical studies, bioavailability and pharmacokinetics of HME productsinjection moulding and HME processing for pharmaceutical materialslaminar dispersive and distributive mixing with dissolution and applications to HMEtechnological considerations related to scale-up of HME processesdevices and implant systems by HMEan FDA perspective on HME product and process understandingimproved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here. …

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Hardback. Condition: New. Discover the latest, fast-developing technology to help move towards more cost-effective, small-batch, decentralized manufacturing of personalized systems 3D printing has revolutionized manufacturing. Its precision and flexibility have enabled the large-scale production of materials and devices too complex for conventional industrial manufacturing. This has been particularly revolutionary in the field of pharmaceutical production, where 3D printing is being integrated into the manufacture of both drugs and drug delivery devices. It has never been more important for industry professionals to understand this form of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside offers a comprehensive overview of 3D printing technology and its pharmaceutical applications. It introduces readers to a world in which bespoke drug delivery systems developed for specific users or conditions is rapidly becoming a reality. Its detailed coverage of strategies and industrial processes incorporates the latest research and real-world experience of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside readers will also find: A multi-disciplinary authorial team of industry leadersDiscussion of common technical and regulatory barriers and their possible solutionsFar-ranging discussion of pharmaceutical applications across all sectors 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside is essential reading for pharmaceutical industry professionals and researchers looking to occupy the leading edge.…

Hardcover. Condition: New. Brand new book, sourced directly from publisher. Dispatch time is 3-4 days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

Hardcover. Condition: new. Hardcover. Discover the latest, fast-developing technology to help move towards more cost-effective, small-batch, decentralized manufacturing of personalized systems 3D printing has revolutionized manufacturing. Its precision and flexibility have enabled the large-scale production of materials and devices too complex for conventional industrial manufacturing. This has been particularly revolutionary in the field of pharmaceutical production, where 3D printing is being integrated into the manufacture of both drugs and drug delivery devices. It has never been more important for industry professionals to understand this form of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside offers a comprehensive overview of 3D printing technology and its pharmaceutical applications. It introduces readers to a world in which bespoke drug delivery systems developed for specific users or conditions is rapidly becoming a reality. Its detailed coverage of strategies and industrial processes incorporates the latest research and real-world experience of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside readers will also find: A multi-disciplinary authorial team of industry leadersDiscussion of common technical and regulatory barriers and their possible solutionsFar-ranging discussion of pharmaceutical applications across all sectors 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside is essential reading for pharmaceutical industry professionals and researchers looking to occupy the leading edge. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

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