Language: English
Published by Createspace Independent Publishing Platform, 2016
ISBN 10: 1530372658 ISBN 13: 9781530372652
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Paperback. Condition: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.
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Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: Spanish
Published by El Ciervo, 1967
Seller: Libros Angulo, Madrid, M, Spain
Encuadernación de tapa blanda. Condition: Bien. El Ciervo, 1967. Revista mensual número 157. Religión. 58 pp. 18 x 13. Tapa blanda de editorial ilustrada. Sin subrayados. Buen estado de conservación.
Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Published by Royal Society of Chemistry RSC, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
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Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Language: English
Published by Royal Society of Chemistry, Cambridge, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.
Hardcover. Condition: new. Hardcover. Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Language: English
Published by Rsc, 2012
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Published by Nova Science Pub Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
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Language: English
Published by Nova Science Pub Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
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Language: English
Published by Nova Science Publishers Inc, New York, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.
Hardcover. Condition: new. Hardcover. The aim of this book is to illustrate the big opportunity to transfer computational techniques, well accepted and used in medicinal chemistry to food science; through this, we hope to discover new pollutants, possible dangerous food additives, contaminants from industries, xenoestrogens, etc. The paradigm is: if a molecule can interact with a receptor (i.e. a Nuclear Receptor), it can modify the signaling pathway and should be investigated to discover negative effects on food. The interaction can be predicted using in silico techniques well known by medicinal chemists to discover new lead compounds or to study the behavior of a protein ligand interaction. The book starts with an introduction about the computational methods applied to food safety by authors coming from a big food company, who elucidate the importance of this approach for industries and food agencies. In Chapter Two, the authors give an overview of in vivo tests for food contaminant and toxin evaluation. In Chapter Three, in vitro and in silico models of digestion are compared.In Chapter Four, the authors, belonging both to an in silico lab and a wet lab use a case study of poliphenols to show how to merge in silico prediction and in vitro controls to gain time and money in estrogen receptors. Additionally, poliphenol binding studies use a molecule modeling approach. In Chapter Five, a non-typical docking approach is presented: a reverse docking approach. Chapter Six and Seven introduce the problem of receptor flexibility and how to treat this important characteristic that must be considered in computational simulations. Chapter Eight is a review about QSAR methods well considered in this approach. Chapter Nine show a non-conventional informatics approach to ab initio in silico protein structure prediction. The last chapter is dedicated to the informatics requirements for in silico simulations to help researchers approaching this field. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Language: English
Published by Nova Science Publishers Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
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HRD. Condition: New. New Book. Shipped from UK. Established seller since 2000.
Language: English
Published by Rsc Publishing, 2012
Seller: Books in my Basket, New Delhi, India
Hardcover. Condition: New. ISBN:9781849733649.
Language: English
Published by Nova Science Pub Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
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Hardcover. Condition: Brand New. 247 pages. 10.50x7.50x0.75 inches. In Stock.
Language: English
Published by Nova Science Publishers Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
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HRD. Condition: New. New Book. Shipped from UK. Established seller since 2000.
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Published by Nova Science Pub Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
Seller: GreatBookPricesUK, Woodford Green, United Kingdom
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Language: English
Published by Nova Science Pub Inc, 2015
ISBN 10: 1634835875 ISBN 13: 9781634835879
Seller: GreatBookPricesUK, Woodford Green, United Kingdom
Condition: New.
Language: English
Published by Royal Society of Chemistry, 2012
ISBN 10: 1849733643 ISBN 13: 9781849733649
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Hardcover. Condition: Like New. Like New. book.