Atul Chopade (45 results)

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    • Language: English

      Published by VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2011

      3844314296 / 9783844314298

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      Condition: New. pp. 68.

    • Language: Spanish

      Published by Ediciones Nuestro Conocimiento, 2021

      620289489X / 9786202894890

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    • Language: English

      Published by LAP LAMBERT Academic Publishing, 2011

      3844314296 / 9783844314298

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      Taschenbuch. Condition: Neu. Effects of Analgesics on Acute Inflammatory Muscle Hyperalgesia | NSAIDs and Acute Inflammatory Muscle Hyperalgesia | Atul Chopade (u. a.) | Taschenbuch | 68 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783844314298 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: French

      Published by AV Akademikerverlag, 2021

      6202894881 / 9786202894883

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    • Language: English

      Published by LAP LAMBERT Academic Publishing, 2011

      3844314296 / 9783844314298

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      Seller: Mispah books, Redhill, SURRE, United KingdomMispah books

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      paperback. Condition: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

    • Language: Dutch

      Published by AV Akademikerverlag, 2021

      6202894938 / 9786202894937

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    • Language: French

      Published by Editions Notre Savoir, 2021

      6202894881 / 9786202894883

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      Taschenbuch. Condition: Neu. Effets des analgésiques sur l'hyperalgésie musculaire inflammatoire aiguë | AINS et hyperalgésie musculaire inflammatoire aiguë | Atul Chopade (u. a.) | Taschenbuch | Französisch | 2021 | Editions Notre Savoir | EAN 9786202894883 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Italian

      Published by AV Akademikerverlag, 2021

      620289492X / 9786202894920

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    • Language: Polish

      Published by AV Akademikerverlag, 2021

      6202894946 / 9786202894944

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    • Language: Portuguese

      Published by AV Akademikerverlag, 2021

      6202894903 / 9786202894906

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    • Language: Dutch

      Published by Uitgeverij Onze Kennis, 2021

      6202894938 / 9786202894937

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      Taschenbuch. Condition: Neu. Effecten van pijnstillers op acute ontstekings spierhyperalgesie | Atul Chopade (u. a.) | Taschenbuch | Niederländisch | 2021 | Uitgeverij Onze Kennis | EAN 9786202894937 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Russian

      Published by Sciencia Scripts, 2021

      6202894954 / 9786202894951

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      Taschenbuch. Condition: Neu. Vozdejstwie anal'getikow na ostruü wospalitel'nuü giperalgeziü myshc | ANBI i ostraq wospalitel'naq giperalgeziq myshc. | Atul Chopade (u. a.) | Taschenbuch | Russisch | 2021 | Sciencia Scripts | EAN 9786202894951 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Portuguese

      Published by Edições Nosso Conhecimento, 2021

      6202894903 / 9786202894906

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      Taschenbuch. Condition: Neu. Efeitos da Analgésica na Hiperalgesia Muscular Inflamatória Aguda | AINE e Hiperalgesia Inflamatória Aguda dos Músculos Inflamatórios | Atul Chopade (u. a.) | Taschenbuch | Portugiesisch | 2021 | Edições Nosso Conhecimento | EAN 9786202894906 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Polish

      Published by Wydawnictwo Nasza Wiedza, 2021

      6202894946 / 9786202894944

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      Seller: preigu, Osnabrück, Germanypreigu

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      Taschenbuch. Condition: Neu. Wp¿yw ¿rodków przeciwbólowych na ostry stan zapalny mi¿¿ni Hyperalgezja | NLPZ i ostre zapalenie mi¿¿ni Hyperalgezja | Atul Chopade (u. a.) | Taschenbuch | Polnisch | 2021 | Wydawnictwo Nasza Wiedza | EAN 9786202894944 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Italian

      Published by Edizioni Sapienza, 2021

      620289492X / 9786202894920

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      Taschenbuch. Condition: Neu. Effetti degli analgesici sull'iperalgesia muscolare infiammatoria acuta | FANS e iperalgesia muscolare infiammatoria acuta | Atul Chopade (u. a.) | Taschenbuch | Italienisch | 2021 | Edizioni Sapienza | EAN 9786202894920 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: German

      Published by Verlag Unser Wissen, 2021

      6202894873 / 9786202894876

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      Taschenbuch. Condition: Neu. Auswirkungen von Analgetika auf die akut entzündliche Muskelhyperalgesie | NSAIDs und akut entzündliche Muskelhyperalgesie | Atul Chopade (u. a.) | Taschenbuch | 72 S. | Deutsch | 2021 | Verlag Unser Wissen | EAN 9786202894876 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

    • Language: Spanish

      Published by Ediciones Nuestro Conocimiento Aug 2021, 2021

      620289489X / 9786202894890

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -El dolor asociado a las afecciones musculoesqueléticas suele inducir a la discapacidad y representa una importante carga financiera para la sociedad en términos de costos de atención de la salud y pérdida de productividad. Por otra parte, los antiinflamatorios no esteroideos (AINE) figuran entre los medicamentos más utilizados en todo el mundo para tratar el dolor y la inflamación. Los AINES inhiben la formación de prostaglandinas mediante la inhibición de las enzimas COX-1 y COX-2. Se ha informado de que el bloqueo de la COX-2 constitutiva de la columna vertebral antes de una lesión tisular puede reducir la sensibilización inicial periférica y central que se produce después de una lesión tisular. En el presente estudio se demostraron los efectos de los inhibidores de la COX en la hiperalgesia mediada por la columna vertebral en modelos de hiperalgesia muscular inflamatoria aguda. La pertinencia clínica de las observaciones del presente trabajo se pone de relieve por los resultados que demuestran claramente que los inhibidores no selectivos de la COX o los inhibidores selectivos de la COX-2 tienen efectos similares en la inversión de la hiperalgesia térmica en el modelo agudo de hiperalgesia muscular. Los AINES mostraron efectos significativos en la máxima eficacia posible, la analgesia y la antihiperalgesia. 68 pp. Spanisch.

    • Published by Sciencia Scripts Aug 2021, 2021

      6202894954 / 9786202894951

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bol', swqzannaq s myshechno-skeletnymi zabolewaniqmi, chasto priwodit k inwalidnosti i predstawlqet soboj znachitel'noe finansowoe bremq dlq obschestwa s tochki zreniq zatrat na zdrawoohranenie i poteri proizwoditel'nosti. S drugoj storony, nesteroidnye protiwowospalitel'nye preparaty (NPVP) qwlqütsq odnimi iz naibolee chasto ispol'zuemyh wo wsem mire lekarstw dlq lecheniq boli i wospaleniq. Nesteroidnye protiwowospalitel'nye preparaty podawlqüt obrazowanie prostaglandina putem ingibirowaniq fermentow COG-1 i COG-2. Soobschalos', chto blokirowanie sostawnyh spinnogo COG-2 do powrezhdeniq tkanej mozhet umen'shit' nachal'nuü perifericheskuü i central'nuü sensibilizaciü, kotoraq proishodit posle powrezhdeniq tkanej. Nastoqschee issledowanie prodemonstrirowalo wliqnie ingibitorow COG na spinal'no oposredowannuü giperalgeziü w modelqh ostroj wospalitel'noj giperalgezii myshc. Klinicheskaq znachimost' nablüdenij w nastoqschej rabote podcherkiwaetsq rezul'tatami, kotorye naglqdno demonstriruüt, chto neizbiratel'nye ingibitory COG ili izbiratel'nye ingibitory COG-2 okazywaüt shozhee wozdejstwie na rewers termicheskoj giperalgezii na modeli ostroj myshechnoj giperalgezii. NSAIDy pokazali znachitel'noe wliqnie na maximal'nuü wozmozhnuü äffektiwnost', anal'geziü i antigiperalgeziü. 72 pp. Russisch.

    • Language: French

      Published by Editions Notre Savoir Aug 2021, 2021

      6202894881 / 9786202894883

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -La douleur associée aux troubles musculo-squelettiques induit souvent une invalidité et représente une charge financière importante pour la société en termes de coûts de soins de santé et de perte de productivité. D'autre part, les anti-inflammatoires non stéroïdiens (AINS) sont parmi les médicaments les plus utilisés dans le monde pour traiter la douleur et l'inflammation. Les AINS inhibent la formation de prostaglandines par l'inhibition des enzymes COX-1 et COX-2. Il a été signalé que le blocage de la COX-2 constitutive de la colonne vertébrale avant une lésion tissulaire peut réduire la sensibilisation périphérique et centrale initiale qui se produit après une lésion tissulaire. La présente étude a démontré les effets des inhibiteurs de la COX sur l'hyperalgésie à médiation spinale dans des modèles d'hyperalgésie musculaire inflammatoire aiguë. La pertinence clinique des observations du présent travail est soulignée par des résultats qui démontrent clairement que les inhibiteurs non sélectifs de la COX ou les inhibiteurs sélectifs de la COX-2 ont des effets similaires sur l'inversion de l'hyperalgésie thermique sur un modèle d'hyperalgésie musculaire aiguë. Les AINS ont montré des effets significatifs sur l'efficacité maximale possible, l'analgésie et l'antihyperalgésie. 72 pp. Französisch.

    • Language: Spanish

      Published by Ediciones Nuestro Conocimiento

      620289489X / 9786202894890

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      Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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      Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - El dolor asociado a las afecciones musculoesqueléticas suele inducir a la discapacidad y representa una importante carga financiera para la sociedad en términos de costos de atención de la salud y pérdida de productividad. Por otra parte, los antiinflamatorios no esteroideos (AINE) figuran entre los medicamentos más utilizados en todo el mundo para tratar el dolor y la inflamación. Los AINES inhiben la formación de prostaglandinas mediante la inhibición de las enzimas COX-1 y COX-2. Se ha informado de que el bloqueo de la COX-2 constitutiva de la columna vertebral antes de una lesión tisular puede reducir la sensibilización inicial periférica y central que se produce después de una lesión tisular. En el presente estudio se demostraron los efectos de los inhibidores de la COX en la hiperalgesia mediada por la columna vertebral en modelos de hiperalgesia muscular inflamatoria aguda. La pertinencia clínica de las observaciones del presente trabajo se pone de relieve por los resultados que demuestran claramente que los inhibidores no selectivos de la COX o los inhibidores selectivos de la COX-2 tienen efectos similares en la inversión de la hiperalgesia térmica en el modelo agudo de hiperalgesia muscular. Los AINES mostraron efectos significativos en la máxima eficacia posible, la analgesia y la antihiperalgesia.

    • Language: English

      Published by LAP LAMBERT Academic Publishing Mrz 2011, 2011

      3844314296 / 9783844314298

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Pain associated with muscoskeletal conditions often induce disability and represent a significant financial burden to society in terms of health care costs and lost productivity. On the other hand, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide to treat pain and inflammation. NSAIDs inhibit prostaglandin formation through inhibition of both the COX-1 and COX-2 enzymes. It has been reported that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury. The present study demonstrated the effects of COX inhibitors on spinally mediated hyperalgesia in models of acute inflammatory muscle hyperalgesia. The clinical relevancy of the observations in present work is emphasized by results that clearly demonstrate that nonselective COX inhibitors or COX-2-selective inhibitors have similar effects on the reversal of thermal hyperalgesia on acute model of muscle hyperalgesia. The NSAIDs showed significant effects on Maximum Possible Effectiveness, Analgesia and Antihyperalgesia. 68 pp. Englisch.

    • Language: Dutch

      Published by Uitgeverij Onze Kennis Aug 2021, 2021

      6202894938 / 9786202894937

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Pijn in verband met aandoeningen van het bewegingsapparaat leidt vaak tot invaliditeit en vormt een aanzienlijke financiële last voor de samenleving in termen van kosten voor de gezondheidszorg en productiviteitsverlies. Aan de andere kant behoren niet-steroïdale ontstekingsremmende middelen (NSAID's) tot de meest gebruikte geneesmiddelen ter wereld voor de behandeling van pijn en ontstekingen. NSAID's remmen de vorming van prostaglandine door remming van zowel de COX-1 als COX-2 enzymen. Het is gemeld dat het blokkeren van constitutieve ruggengraat COX-2 voor weefselschade de initiële perifere en centrale sensibilisatie die optreedt na weefselschade kan verminderen. De huidige studie toonde de effecten van COX-remmers op spinaal gemedieerde hyperalgesie aan in modellen van acute inflammatoire spierhyperalgesie. De klinische relevantie van de waarnemingen in het huidige werk wordt benadrukt door resultaten die duidelijk aantonen dat niet-selectieve COX-remmers of COX-2-selectieve remmers vergelijkbare effecten hebben op de omkering van thermische hyperalgesie in modellen van acute spierhyperalgesie. De NSAID's toonden significante effecten op Maximale Mogelijke Effectiviteit, Analgesie en Antihyperalgesie. 68 pp. Niederländisch.

    • Language: English

      Published by VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2011

      3844314296 / 9783844314298

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      Seller: Majestic Books, Hounslow, United KingdomMajestic Books

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      Condition: New. Print on Demand pp. 68 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

    • Language: English

      Published by VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2011

      3844314296 / 9783844314298

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      Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios

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      Condition: New. PRINT ON DEMAND pp. 68.

    • Language: English

      Published by LAP LAMBERT Academic Publishing, 2011

      3844314296 / 9783844314298

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      Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: CHOPADE ATULAtul R. Chopade, He is presently working as Asst. Professor,at Dept. of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, taluka- Walwa, Dist- Sangli. 415404 MS India. His areas of research are Experimental Pharmac.

    • Language: German

      Published by Verlag Unser Wissen Aug 2021, 2021

      6202894873 / 9786202894876

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Schmerzen im Zusammenhang mit Muskel-Skelett-Erkrankungen führen häufig zu Behinderungen und stellen eine erhebliche finanzielle Belastung für die Gesellschaft dar, was die Gesundheitskosten und Produktivitätsverluste betrifft. Andererseits gehören nicht-steroidale Antirheumatika (NSAR) zu den weltweit am häufigsten verwendeten Medikamenten zur Behandlung von Schmerzen und Entzündungen. NSAR hemmen die Bildung von Prostaglandin durch Hemmung sowohl des COX-1- als auch des COX-2-Enzyms. Es wurde berichtet, dass die Blockierung des konstitutiven spinalen COX-2 vor der Gewebeschädigung die anfängliche periphere und zentrale Sensibilisierung nach der Gewebeschädigung verringern kann. In der vorliegenden Studie wurden die Auswirkungen von COX-Inhibitoren auf die spinal vermittelte Hyperalgesie in Modellen der akuten entzündlichen Muskelhyperalgesie gezeigt. Die klinische Relevanz der Beobachtungen in der vorliegenden Arbeit wird durch Ergebnisse unterstrichen, die eindeutig zeigen, dass nicht-selektive COX-Inhibitoren oder COX-2-selektive Inhibitoren ähnliche Wirkungen auf die Umkehrung der thermischen Hyperalgesie am Modell der akuten Muskelhyperalgesie haben. Die NSAIDs zeigten signifikante Effekte auf die maximal mögliche Wirksamkeit, die Analgesie und die Antihyperalgesie. 72 pp. Deutsch.

    • Language: Portuguese

      Published by Edições Nosso Conhecimento Aug 2021, 2021

      6202894903 / 9786202894906

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As dores associadas às condições muscoesqueléticas induzem frequentemente a incapacidade e representam um encargo financeiro significativo para a sociedade em termos de custos de cuidados de saúde e perda de produtividade. Por outro lado, os anti-inflamatórios não esteróides (AINEs) estão entre os medicamentos mais utilizados no mundo inteiro para tratar a dor e inflamação. Os AINEs inibem a formação de prostaglandinas através da inibição tanto das enzimas COX-1 como COX-2. Tem sido relatado que o bloqueio da COX-2 constitutiva da coluna vertebral antes da lesão tecidual pode reduzir a sensibilização inicial periférica e central que ocorre após a lesão tecidual. O presente estudo demonstrou os efeitos dos inibidores de COX na hiperalgesia mediada por spinally em modelos de hiperalgesia inflamatória aguda do músculo. A relevância clínica das observações no presente trabalho é enfatizada por resultados que demonstram claramente que os inibidores não selectivos de COX ou os inibidores selectivos de COX-2 têm efeitos semelhantes na reversão da hiperalgesia térmica no modelo agudo de hiperalgesia muscular. Os AINE mostraram efeitos significativos na Máxima Eficácia Possível, Analgesia e Anti-hiperalgesia. 68 pp. Portugiesisch.

    • Language: Italian

      Published by Edizioni Sapienza Aug 2021, 2021

      620289492X / 9786202894920

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Il dolore associato alle condizioni muscoloscheletriche spesso induce la disabilità e rappresenta un onere finanziario significativo per la società in termini di costi sanitari e di perdita di produttività. D'altra parte, i farmaci antinfiammatori non steroidei (FANS) sono tra i più usati al mondo per trattare il dolore e l'infiammazione. I FANS inibiscono la formazione di prostaglandine attraverso l'inibizione degli enzimi COX-1 e COX-2. È stato riportato che il blocco della COX-2 costitutiva della colonna vertebrale prima della lesione tissutale può ridurre la sensibilizzazione iniziale periferica e centrale che si verifica dopo la lesione tissutale. Il presente studio ha dimostrato gli effetti degli inibitori COX sull'iperalgesia mediata dalla colonna vertebrale in modelli di iperalgesia muscolare infiammatoria acuta. La rilevanza clinica delle osservazioni del presente lavoro è sottolineata dai risultati che dimostrano chiaramente che gli inibitori COX non selettivi o gli inibitori COX-2 selettivi hanno effetti simili sull'inversione dell'iperalgesia termica sul modello acuto di iperalgesia muscolare. I FANS hanno mostrato effetti significativi sulla massima efficacia possibile, sull'analgesia e sull'antiperalgesia. 68 pp. Italienisch.

    • Language: Polish

      Published by Wydawnictwo Nasza Wiedza Aug 2021, 2021

      6202894946 / 9786202894944

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      Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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      Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ból zwi¿zany ze schorzeniami uk¿adu mi¿¿niowo-szkieletowego cz¿sto powoduje niepe¿nosprawnö¿ i stanowi znaczne obci¿¿enie finansowe dla spöecze¿stwa pod wzgl¿dem kosztów opieki zdrowotnej i utraty produktywnöci. Z drugiej strony niesteroidowe leki przeciwzapalne (NLPZ) s¿ jednymi z najcz¿¿ciej stosowanych na ¿wiecie leków w leczeniu bólu i stanów zapalnych. NLPZ hamuj¿ powstawanie prostaglandyn poprzez hamowanie zarówno enzymów COX-1, jak i COX-2. Zg¿aszano, ¿e blokowanie konstytutywnego COX-2 rdzenia kr¿gowego przed uszkodzeniem tkanek möe zmniejszy¿ pocz¿tkowe obwodowe i centralne uczulenie, które wyst¿puje po uszkodzeniu tkanki. W niniejszej pracy wykazano wp¿yw inhibitorów COX na hiperalgezj¿ z przewodnictwem kolczystym w modelach ostrej hiperalgezji zapalnej mi¿¿ni. Znaczenie kliniczne obserwacji w niniejszej pracy podkre¿laj¿ wyniki, które jednoznacznie wskazuj¿, ¿e nieselektywne inhibitory COX lub inhibitory COX-2 maj¿ podobny wp¿yw na odwrócenie hiperalgezji termicznej w ostrym modelu hiperalgezji mi¿¿niowej. Nieselektywne inhibitory COX lub inhibitory COX-2-selektywne maj¿ podobny wp¿yw na odwrócenie hiperalgezji termicznej na ostry model hiperalgezji mi¿¿ni. 68 pp. Polnisch.

    • Language: English

      Published by LAP LAMBERT Academic Publishing Mär 2011, 2011

      3844314296 / 9783844314298

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      Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000

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      Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Pain associated with muscoskeletal conditions often induce disability and represent a significant financial burden to society in terms of health care costs and lost productivity. On the other hand, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide to treat pain and inflammation. NSAIDs inhibit prostaglandin formation through inhibition of both the COX-1 and COX-2 enzymes. It has been reported that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury. The present study demonstrated the effects of COX inhibitors on spinally mediated hyperalgesia in models of acute inflammatory muscle hyperalgesia. The clinical relevancy of the observations in present work is emphasized by results that clearly demonstrate that nonselective COX inhibitors or COX-2-selective inhibitors have similar effects on the reversal of thermal hyperalgesia on acute model of muscle hyperalgesia. The NSAIDs showed significant effects on Maximum Possible Effectiveness, Analgesia and Antihyperalgesia.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 68 pp. Englisch.