Effects of Analgesics on Acute Inflammatory Muscle Hyperalgesia

Language: English

Published by LAP LAMBERT Academic Publishing Mär 2011, 2011

3844314296 / 9783844314298

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This item is printed on demand - Print on Demand Titel. Neuware -Pain associated with muscoskeletal conditions often induce disability and represent a significant financial burden to society in terms of health care costs and lost productivity. On the other hand, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide to treat pain and inflammation. NSAIDs inhibit prostaglandin formation through inhibition of both the COX-1 and COX-2 enzymes. It has been reported that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury. The present study demonstrated the effects of COX inhibitors on spinally mediated hyperalgesia in models of acute inflammatory muscle hyperalgesia. The clinical relevancy of the observations in present work is emphasized by results that clearly demonstrate that nonselective COX inhibitors or COX-2-selective inhibitors have similar effects on the reversal of thermal hyperalgesia on acute model of muscle hyperalgesia. The NSAIDs showed significant effects on Maximum Possible Effectiveness, Analgesia and Antihyperalgesia.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 68 pp. Englisch.

Seller Inventory # 9783844314298

Title
Effects of Analgesics on Acute Inflammatory Muscle Hyperalgesia
Author
Atul Chopade
Publisher
LAP LAMBERT Academic Publishing Mär 2011
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3844314296
ISBN 13
9783844314298
Item weight
119 grams
Dimensions
220x150x5 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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