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Language: English
Published by LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6200457700 ISBN 13: 9786200457707
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Language: English
Published by Taylor & Francis Ltd, 2019
ISBN 10: 0367395959 ISBN 13: 9780367395957
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Published by LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6200457700 ISBN 13: 9786200457707
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Taschenbuch. Condition: Neu. Biological effects of food colouring | Studies in in vivo and in vitro model systems | Tania Merinas-Amo (u. a.) | Taschenbuch | 56 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786200457707 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
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Language: English
Published by CRC Press 2002-08-08, 2002
ISBN 10: 0415277248 ISBN 13: 9780415277242
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Hardcover. Condition: Brand New. 1st edition. 452 pages. 9.50x7.00x0.75 inches. In Stock.
Language: English
Published by LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6200457700 ISBN 13: 9786200457707
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Suitability of certain food colouring is nowadays being in discussion due to their effects on human health. For that reason, in the present work the biological effects of six worldwide used food colouring (Riboflavin, Tartrazine, Carminic Acid, Erythrosine, Indigotine and Brilliant Blue FCF) are analysed in two model systems.Methods: In vivo toxicity, antitoxicity and longevity assays using the model organism Drosophila melanogaster, and in vitro cytotoxicity, DNA fragmentation and methylation status assays using HL-60 tumour human cell line were carried out.Results: Our in vivo results showed safe effects Drosophila for all the food colouring treatments, non-significant protective potential against an oxidative toxin and different behaviour on the lifespan of flies. The in vitro results in HL-60 cells showed that food colouring not only increased the tumour cells growth but also no DNA damage or modifications in the methylation status were induced at their ADI concentrations.Conclusions: Regarding the in vivo and in vitro studies, results would support the idea that a high chronic intake of the food colouring throughout the entire life is not advisable.
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Over the past ten years, sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been very useful in characterizing the permeability of drugs across epithelial tissues, and in studying carrier systems for improved drug delivery and enhanced absorption. Compared to in vivo trials, cell culture models are faster, more convenient and cost effective, ethically advantageous, and more easily standardized. This book provides a practical approach to such in vitro techniques. It is an invaluable source of information for graduate students and pharmaceutical scientists in industry or in academia.
Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and enhanced absorption. Compared to in vivo trials on animals or humans, cell culture models are faster, more convenient and cost effective, ethically advantageous and, most importantly, they can be more easily standardized and validated.This book provides a practical approach to contemporary cell culture-based in vitro techniques for drug transport studies at biological absorption barriers. It is an invaluable source of information for students attending graduate courses on this subject and pharmaceutical scientists working in industry or in academia.