Immunochemistry Application Principles Physical by Svante Arrhenius (39 results)

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New York, The Macmillan Company, 1907, kl.-8°, IX, (2), 399, (5) pp., orig. Leinenband; St. verso. Tit. First Edition! Svante August Arrhenius (1859-1927) "defined immunochemistry, and laid out its frontiers". Garrison & Morton "Svante August Arrhenius (1859-1927) a Swedish scientist awarded the Nobel Prize in Chemistry (1903), for his discovery of electrolytic dissociation. He is also known as a prescient atmospheric physicist as he already in 1896 demonstrated the effect of radiatively active gases on planetary surface temperatures and made an attempt to quantify what he called the "greenhouse effect" especially of carbon dioxide on the earth's climate. His scientific career encompassed three distinct specialties within the broad fields of physics and chemistry: physical chemistry, cosmic physics, and the chemistry of immunology." "Among the many scientists that joined Arrhenius at the Nobel Institute was Thorwald Madsen from the Danish Serum Institute in Copenhagen who wanted to apply the new physical chemistry arguments to shed light on the "toxin-antitoxin" affinity reaction. This reaction was observed when a serum sample from an infected patient was added to a suspension of the micro-organisms that had caused the infection. The affinity question was raised at a time when our knowledge of proteins and their complex architecture was non-existent. The serological studies by the two colleagues met with opposition from those who opined that chemical models were inappropriate to explain the intricate processes of life. The opponents included supporters of the highly regarded physiologist Paul Ehrlich in Frankfurt, who had formulated the so-called "side-chain theory" of the immune response which postulated that the reaction involved a sequential formation and secretion of a series of complex reactive vesicles. This stood in stark contrast to the Arrhenius concept of the existence of a well-defined binding equilibrium between two entities, in turn considered to be a ridiculously simplistic notion by the opponents. The "Arrhenius-Ehrlich controversy" became quite a cause célèbre in the scientific community and the debate initiated by the two scientists raged for several years after the turn of the century. Arrhenius, who was always ready to express himself clearly in his writings supplemented by considerable experimental data, compiled a series of research reports that he had presented at the University of California, Berkeley in 1904, into a volume that he published under the title "Immunochemistry". By his insistence that chemical principles were at work even in physiological reactions he became the recognised father of an entirely new discipline." A Tribute to the Memory of Presented at the 2008 Annual Meeting of the Royal Swedish Academy of Engineering Sciences by Gustaf Arrhenius, Karin Caldwell and Svante Wold See - Rubin, L.P., Styles in Scientific Explanation: Paul Ehrlich and Svante Arrhenius on Immunochemistry, J. Hist. Medicine, October 1980, pp. 397-425. Garrison & Morton No. 2564.1; "Important Books in Immunology, 1892-1968" Silverstein.…

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