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Published by Singapore, Springer., 2019
ISBN 10: 9811359970 ISBN 13: 9789811359972
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Seller: Ria Christie Collections, Uxbridge, United Kingdom
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Language: English
Published by Springer-Verlag New York Inc., 2010
ISBN 10: 1441924140 ISBN 13: 9781441924148
Seller: THE SAINT BOOKSTORE, Southport, United Kingdom
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Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.
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Seller: Revaluation Books, Exeter, United Kingdom
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Taschenbuch. Condition: Neu. High-Dimensional Data Analysis in Cancer Research | Xiaochun Li (u. a.) | Taschenbuch | Applied Bioinformatics and Biostatistics in Cancer Research | viii | Englisch | 2010 | Springer | EAN 9781441924148 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data. With the advent of high-throughput technologies, various types of high-dimensional data have been generated in recent years for the understanding of biological processes, especially processes that relate to disease occurrence or management of cancer. Motivated by these important applications in cancer research, there has been a dramatic growth in the development of statistical methodology in the analysis of high-dimensional data, particularly related toregression model selection, estimation and prediction.High-Dimensional Data Analysis in Cancer Research, edited by Xiaochun Li and Ronghui Xu, is a collective effort to showcase statistical innovations for meeting the challenges and opportunities uniquely presented by the analytical needs of high-dimensional data in cancer research, particularly in genomics and proteomics. All the chapters included in this volume contain interesting case studies to demonstrate the analysis methodology.High-Dimensional Data Analysis in Cancer Research is an invaluable reference forresearchers, statisticians, bioinformaticians, graduate students and data analysts working in the fields of cancer research.
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.
Seller: Mispah books, Redhill, SURRE, United Kingdom
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Seller: Revaluation Books, Exeter, United Kingdom
Hardcover. Condition: Brand New. 448 pages. 9.25x6.10x1.14 inches. In Stock.
Language: English
Published by Springer Nature Singapore, Springer Nature Singapore, 2019
ISBN 10: 9811359970 ISBN 13: 9789811359972
Seller: AHA-BUCH GmbH, Einbeck, Germany
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks.Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratioof SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel.Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.
Language: English
Published by Springer, 2009
Seller: Books in my Basket, New Delhi, India
Hardcover. Condition: New. ISBN:9780387697635.
Seller: Mispah books, Redhill, SURRE, United Kingdom
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Seller: Brook Bookstore On Demand, Napoli, NA, Italy
Condition: new. Questo è un articolo print on demand.
Language: English
Published by Springer New York Nov 2010, 2010
ISBN 10: 1441924140 ISBN 13: 9781441924148
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data. With the advent of high-throughput technologies, various types of high-dimensional data have been generated in recent years for the understanding of biological processes, especially processes that relate to disease occurrence or management of cancer. Motivated by these important applications in cancer research, there has been a dramatic growth in the development of statistical methodology in the analysis of high-dimensional data, particularly related toregression model selection, estimation and prediction.High-Dimensional Data Analysis in Cancer Research, edited by Xiaochun Li and Ronghui Xu, is a collective effort to showcase statistical innovations for meeting the challenges and opportunities uniquely presented by the analytical needs of high-dimensional data in cancer research, particularly in genomics and proteomics. All the chapters included in this volume contain interesting case studies to demonstrate the analysis methodology.High-Dimensional Data Analysis in Cancer Research is an invaluable reference forresearchers, statisticians, bioinformaticians, graduate students and data analysts working in the fields of cancer research. 168 pp. Englisch.
Language: English
Published by Springer New York Dez 2008, 2008
ISBN 10: 0387697632 ISBN 13: 9780387697635
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data. 172 pp. Englisch.
Seller: moluna, Greven, Germany
Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Poses new challenges and calls for scalable solutions to the analysis of such high dimensional dataPresent the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-di.
Seller: moluna, Greven, Germany
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Poses new challenges and calls for scalable solutions to the analysis of such high dimensional dataPresent the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-di.
Seller: Majestic Books, Hounslow, United Kingdom
Condition: New. Print on Demand pp. 170 23 Illus. (6 Col.).