Design Development Nitrendipin Self Microemulsifying by Shinde Anilkumar (9 results)
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Taschenbuch. Condition: Neu. Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery | Nitrendipin Self-Microemulsifying Drug Delivery System | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2023 | LAP LAMBERT Academic Publishing | EAN 9786207448104 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, L…engericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
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Published by LAP LAMBERT Academic Publishing Nov 2023, 2023
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 52 pp. Englisch.
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on satura…ted solubility studies and surfactant an.
Language: English
Published by LAP LAMBERT Academic Publishing Nov 2023, 2023
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility stud…ies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, self micro emulsification time and drug content determination. The optimized formulation exhibited 98 % in vitro drug release, which was significantly higher than that of the drug solution. Infrared spectroscopy, differential scanning calorimetric, SEM and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. From the stability studies of solid SMEDDS, there was no significant decrease in drug release and drug content, hence the formulation is found to be stable and then Comparative in vitro release study of optimised batch.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 52 pp. Englisch.
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studi…es and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, self micro emulsification time and drug content determination. The optimized formulation exhibited 98 % in vitro drug release, which was significantly higher than that of the drug solution. Infrared spectroscopy, differential scanning calorimetric, SEM and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. From the stability studies of solid SMEDDS, there was no significant decrease in drug release and drug content, hence the formulation is found to be stable and then Comparative in vitro release study of optimised batch.
