Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery : Nitrendipin Self-Microemulsifying Drug Delivery System
Language: English
Published by LAP LAMBERT Academic Publishing, 2023
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 42.80
Quantity: 1 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, self micro emulsification time and drug content determination. The optimized formulation exhibited 98 % in vitro drug release, which was significantly higher than that of the drug solution. Infrared spectroscopy, differential scanning calorimetric, SEM and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. From the stability studies of solid SMEDDS, there was no significant decrease in drug release and drug content, hence the formulation is found to be stable and then Comparative in vitro release study of optimised batch.…
Seller Inventory # 9786207448104
- Title
- Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery : Nitrendipin Self-Microemulsifying Drug Delivery System
- Author
- Anilkumar Shinde
- Publisher
- LAP LAMBERT Academic Publishing
- Publication year
- 2023
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 6207448103
- ISBN 13
- 9786207448104
- Item weight
- 96 grams
- Dimensions
- 220x150x4 mm
"Synopsis" may belong to another edition of this title.
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