Upendra Bhele (13 results)
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Paperback. Condition: Brand New. 108 pages. 8.66x5.91x0.25 inches. In Stock.
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Taschenbuch. Condition: Neu. Comparative QSAR Studies of Benzamidine Derivatives via in-silico tool | Chemoinformatics for making better decisions faster in the area of drug lead identification | Upendra Bhele | Taschenbuch | 108 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783659260469 | Verantwortliche Person…für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
Language: English
Published by LAP LAMBERT Academic Publishing Okt 2012, 2012
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack)… and of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods. 108 pp. Englisch.
Language: English
Published by LAP LAMBERT Academic Publishing Dez 2013, 2013
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among…these the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase. 96 pp. Englisch.
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Seller: moluna, Greven, Germanymoluna
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bhele UpendraAs a Bioinformatics postgraduate(MSc, MTech), Upendra Bhele has worked on various Chemoinfomatics and Pharmacoinformatics projects. He has various research papers published under his name.T…hrombosis - localized clott.
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Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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Seller: moluna, Greven, Germanymoluna
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bhele UpendraAs a Bioinformatics postgraduate (MSc, MTech) Upendra Bhele has worked on various projects as chemoinformatics, pharmacoinformatics and docking studies. He has various research papers under… his nameCopper containing .
Language: English
Published by LAP LAMBERT Academic Publishing Okt 2012, 2012
- Softcover
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Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and… of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 108 pp. Englisch.
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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Thrombosis - localized clotting of the blood - can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and…of about 80% of strokes, collectively the most common cause of death in the developed world. Antiplatelet drugs are used for both the prevention and the acute treatment of arterial thrombosis. These drugs target the activation and the aggregation of platelets. Rivaroxaban is an orally available inhibitor of activated factor X. To enlighten this subject, Benzamidine Derivatives as Factor Xa Inhibitors are the target molecules used for the QSAR studies and an Assessment of Compatibility of Dataset to Statistical Methods is performed by the use of various in silico tools.For model validation the dataset is divided into training set and test set to generate the QSAR model validation report followed by the calibration of the IC-50 value of the representative molecules using MLR, ANN and SVM Methods.
Language: English
Published by LAP LAMBERT Academic Publishing Dez 2013, 2013
- Softcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among thes…e the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.
- Softcover
- Print on Demand
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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£ 48.44
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these… the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
