Ozols J (43 results)

Condition: acceptable. Ausreichend/Acceptable: Exemplar mit vollständigem Text und sämtlichen Abbildungen oder Karten. Schmutztitel oder Vorsatz können fehlen. Einband bzw. Schutzumschlag weisen unter Umständen starke Gebrauchsspuren auf. / Describes a book or dust jacket that has the complete text pages (including those with maps or plates) but may lack endpapers, half-title, etc. (which must be noted). Binding, dust jacket (if any), etc may also be worn.…

Condition: good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present.

Hardcover. Condition: Very Good. ***Please Read*** Latvian edition - Book shows slight wear with no DJ - interior is tight and clean - 528 pages - my shelf location - 32-a-53*.

HC. Condition: Gut. Ohln, originalgetreuer Umschlag (Faks,), ., gr 8?,368s., in gutem Zustand, [GSA7,6a] Deu 700g.

Hardcover. Condition: Very Good. 0792328361. Pharmaceutical company library hardcover, with minimal wear. 294 pages, index, illustrated with charts, tables and diagrams. Drug development has resulted in successful responses in childhood leukemia, testicular cancer and Hodgkin's disease. However, there are still many cancer-related deaths. Drug resistance is largely responsible for these failures and continues to be an area of active investigation. Drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, allowing us to explore the relationship between structure and function. In addition to clinical trials aimed at reversing MDR mediated drug resistance, gene therapy studies with MDR 1 gene retrovirally transduced into human bone marrow cells are described. MDR is the most understood mechanism of drug resistance, we are increasing our knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. Many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As understanding of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. Contents clean, tight and bright. Book. …

PF. Condition: New. This item is printed on demand. Brand new book, sourced directly from publisher. Dispatch time is 6-7 days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Condition: New.

Condition: New.

Condition: New.

Condition: As New. Unread book in perfect condition.

Condition: New. In English.

Condition: New. In English.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. …

Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.…

Hardcover. Condition: Very Good.

Condition: New. pp. 312.

Paperback. Condition: Brand New. reprint edition. 308 pages. 9.25x6.10x0.74 inches. In Stock.

Condition: New. pp. 312.

Hardcover. Condition: Brand New. 10.00x6.75x0.75 inches. In Stock.

Condition: As New. Unread book in perfect condition.

Paperback. Condition: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Riga. Zinatne. 192 pp., 104 figs, hardcover gr. 8 [17.5 x 22 cm] [in Latvian].

M. Portr. u. einigen Abb. 621 S. OLwd. et 0 gr.

Condition: Gut. Zustand: Gut | Seiten: 200 | Sprache: Deutsch | Produktart: Bücher | Keine Beschreibung verfügbar.

Paperback / softback. Condition: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days.

Condition: New. Print on Demand.

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Meet Jim. He has some typical problems: his marriage is on the rocks and his relationship with his teenage kids is even worse. He's been betrayed professionally, and exploited by a gun-running uncle. And he's stranded 50,000 years in the past. This is a world before civilization - a world of fierce Neanderthals and Cro Magnons, of cruel death or hard-won life. Caught in the middle of a bloody epic war that will determine the future course of human history, Jim and his family must find the strength to survive. Can a young boy become a commander of armies Can a teenage girl become a spiritual leader Can a husband and wife rediscover the vitality of their love, and the depth of their true courage, in the face of impossible odds So begins the first volume of the Clan of the Cave-Lion saga.…

Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnMeet Jim. He has some typical problems: his marriage is on the rocks and his relationship with his teenage kids is even worse. He s been betrayed professionally, and exploited by a gun-running uncle.nn nnAnd he s stranded 50,000 y.…