Michell Mario Reimer (5 results)
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Okt 2015, 2015
- Softcover
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. Neuware -Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggestin…g that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease. 100 pp. Englisch.
Language: English
Published by Südwestdeutscher Verlag für Hochschulschriften, 2015
- Softcover
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Taschenbuch. Condition: Neu. Motor neuron regeneration in the spinal cord of adult zebrafish | (HAMILTON, 1822) | Michell Mario Reimer | Taschenbuch | 100 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838117065 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 4…9078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
Language: English
Published by Südwestdeutscher Verlag für Hochschulschriften, 2010
- Softcover
- Print on Demand
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Reimer Michell MarioDr. Michell M. Reimer is a researcher at the University ofEdinburgh, UK. His area of interest is the role ofoligodendrocyte precursor cells (such as the ependymo-radialglial cells in… zebrafish) and oligodendrocyte.
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften Mai 2010, 2010
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Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neuro…ns are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften, 2010
- Softcover
- Print on Demand
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neuron…s are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease.
