Language: English
Published by VDM Verlag Dr. Müller, 2009
ISBN 10: 3639159241 ISBN 13: 9783639159240
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Taschenbuch. Condition: Neu. Tumor Secreted grp170 as a Cancer Vaccine | Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response | Hilal Arnouk | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639159240 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
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Language: English
Published by VDM Verlag Dr. Müller, 2009
ISBN 10: 3639159241 ISBN 13: 9783639159240
Seller: moluna, Greven, Germany
Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Arnouk HilalHilal Arnouk, MD. PhD. has graduated from Roswell Park Cancer nInstitute and is currently a senior postdoctoral fellow at the nUniversity of Alabama at Birmingham. Research interests include ntumor immunotherapy, proteomi.
Language: English
Published by VDM Verlag Dr. Müller, 2009
ISBN 10: 3639159241 ISBN 13: 9783639159240
Seller: AHA-BUCH GmbH, Einbeck, Germany
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Grp170 is a major molecular chaperone/stress protein resident in the ER. It is distantly related in sequence to both hsp110 and hsp70 families. Although most chaperones are intracellular proteins they can be modified into secretory proteins. Chaperones secreted into the tumor microenvironment can recruit professional APCs and promote antigen presentation and priming of T-lymphocytes. This book describes an approach to target grp170 to the tumor microenvironment, which results in tumor rejection mediated by an adaptive immune response that is CD8+ dependent and accompanied by an enhanced cellular immune response against a tumor-specific antigen. Furthermore, the secreted grp170 is shown to deliver full-length tumor antigens to the tumor microenvironment. This approach has the potential of being exploited clinically as a cancer-specific vaccine in tumors of various histological origins.
Language: English
Published by Bod Third Party Titles, 2025
ISBN 10: 0854668632 ISBN 13: 9780854668632
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