Crick Maurice (14 results)

Burgundy Cloth. Condition: VERY GOOD (AVERAGE+). Dust Jacket Condition: Good (BELOW AVERAGE). This book will be POSTED AT OUR STANDARD RATES FULLY INSURED (UK) ONLY . Please email for further details Size: 8vo - over 7¾" - 9¾". Not Illustrated (illustrator). Not Inscribed or Signed.

Burgundy Cloth. Condition: Near Fine (NEAR NEW). Dust Jacket Condition: NEAR FINE (NEAR NEW). First Edition. This book will be POSTED AT OUR STANDARD RATES FULLY INSURED (UK) ONLY . Please email for further details Size: 8vo - over 7¾" - 9¾". Not Illustrated (illustrator). Not Inscribed or Signed.

Couverture souple. Condition: Bon. Broché. 22x14,5 cm. 76 pages. Dans ce numéro : "Lavage et restauration des livres ancien" (H. Dubois d'Enghien); - "Sur les "Liaisons dangereuses" (R. Desprechins); - "Les poèmes de Fernand Séverin" (M. Crick); - "La couverture imprimée de l'Hymne au Soleil, de l'abbé de Reyrac" (P. Van Der Perre); - "Bibliographie - Les Catalogues de Collections particulières (suite)" (C.V.E.); - "Ouvrages de documentation récemment parus" (G.C.); etc. Bon état. Couverture un peu frottée, quelques très légères salissures. Brochage solide.…

Burgundy Cloth. Condition: FINE ( AS BRAND NEW). Dust Jacket Condition: FINE (AS NEW). First Edition. This book will be POSTED AT OUR STANDARD RATES FULLY INSURED (UK) ONLY . Please email for further details Size: 8vo - over 7¾" - 9¾". Not Illustrated (illustrator). Not Inscribed or Signed.

soft cover. Condition: fine. first edition. In-8° broché, 95 pages.

2. In-8°, 23,5 X 16 cm, 379 lots, with 4 b/w plates h.t.mostly of bindings, sewn, orig. wrappers.

First edition, the complete journal volume containing the first four papers on the structure of DNA, signed by Crick on the key 'Molecular Structure of Nucleic Acids' paper. From the library of John D. Mollon, eminent professor of visual neuroscience at Cambridge. First edition, complete volume, signed by Crick on the first paper; 8vo (24.5 x 17 cm); illustrations throughout the text, 1982 ownership inscription of J.D. Mollon to front pastedown, spotting to early and late leaves; contemporary green library cloth, titles to spine gilt, red speckled edges, corners bumped and worn, a little wear at the ends of the spine, lower joint just starting, very good condition; 1168pp, 64 page index. …

Hardcover. Condition: VG+. Volume 171 J.D.Watson and F.H.C. Crick, "Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid", 737 J.D.Watson and F.H.C. Crick, "Genetical Implications of the Structure of Deoxyribonuclei. Quarto. Three volumes, each bound in blue cloth with label to spine. Occasional fingersoiling and pencil marginalia. Light foxing to block edges of Vol. 172. Vol. 171 with inked and embossed stamps of Naval Research Laboratory Library to title page. Tape repair to 1181/82 of Vol. 172. Signed by Crick at first page of each of three articles he co-authored (twice in Vol. 171, once in Vol. 192). Housed in blue cloth slipcase. Vol. 171: [ii], 1168, iii-llxiv. Vol. 172: lxxi, [1], 1200 pp. Vol. 192: cvii, [cviii, blank], xiv-xvi, 50, xvii-xxx, 51-70, xxxi-xxxii, 71-94, lxi-lxiv, 95-112, lxv-lxxx, 113-194, cvii-cxxii, 195-292, clv-clxxii, 293-372, clxxii-clxxiv, 373-386, cciii-ccxxii, 387-484, ccxlvii-cclxv, 485-586, cclxxxix-cccviii, 587-688, cccxxxiii-cccl, 689-784, ccclxxxi-ccccxviii, 785-989, ccccxli-ccccxlviii, 899-1002, cccclxxxiii-dii, 1003-1104, dxxi-dxxxii, 1105-1218, dliii-dlxxii, 1219-1322 Volume 171 J.D.Watson and F.H.C. Crick, "Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid", 737 J.D.Watson and F.H.C. Crick, "Genetical Implications of the Structure of Deoxyribonucleic Acid", 964 Rosalind E. Franklin and R. G. Gosling, "Molecular Structure of Nucleic Acids Molecular Configuration in Sodium Thrymonucleate", 740 M.H.F. Wilkins, A.R. Stokes & H.R. Wilson, "Molecular Structure of Deoxypentose Nucleic Acids", 738 Volume 172 Rosalind E. Franklin and R. G. Gosling, "Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate", 156 M.H.F. Wilkins, W.E. Seeds & A. R. Stokes, H.R. Wilson, "Helical Structure of Crystalline Deoxypentose Nucleic Acid", 759 Volume 192 F.H.C. Crick, Leslie Barnett, S. Brenner, R.J. Watts-Tobin, "General Nature of the Genetic Code for Proteins", 1227. Book.…

First edition. The Molecule That Copies Itself. First edition, in the rare three-paper offprint issue - the author's separate that gathers the whole of the 25 April 1953 Nature announcement - of the discovery of the molecular structure of DNA, the double helix, and with it the mechanism by which living things copy their inheritance. The journal's printer reset the three papers of that issue into a single pamphlet for the authors to send to colleagues. This three-paper offprint is far scarcer than the journal itself. Watson and Crick conducted no experiments of their own. Working at the Cavendish Laboratory in Cambridge across eighteen months, they unified the scattered findings of others into a single structure - two helical sugar-phosphate chains wound about a common axis, running in opposite directions, with the four bases paired across the inside of the ladder. The pairing was the whole of it: adenine always to thymine, cytosine always to guanine, so that the sequence of one strand fixes the sequence of the other. From that single constraint followed the answer to the oldest question in biology - how a gene is copied, with near-perfect fidelity, generation upon generation. The structure the paper sets out is exact and spare. Two right-handed helical chains coil about a common axis, the sugar-phosphate backbones on the outside and the paired bases stacked flat within, perpendicular to the axis; a residue recurs every 3.4 ångström along each chain, the helix repeats after ten residues at intervals of 34 ångström, and the whole forms a cylinder some twenty ångström across. Because the phosphates face outward into the surrounding water, solvent and cations reach them freely, and the model so accounts for the high water content of the fibres that Franklin had measured. Crick's lone schematic - two ribbons winding about a vertical fibre axis, the base-pairs drawn as horizontal rods between them - expresses the entire proposal in a single figure; it is this drawing, since become one of the most reproduced diagrams in modern science, that fills the second page of the present pamphlet. Everything the structure asserts is checked against the X-ray evidence: the perpendicular bases, the regular backbones, the antiparallel chains, each a feature the diffraction pattern demanded rather than a freedom the model-builders allowed themselves. The problem they solved was eighty years in the making. In 1869 the Swiss physiological chemist Friedrich Miescher, washing the pus from used surgical bandages to isolate the proteins of white blood cells, instead struck a substance from the cell nucleus richer in phosphorus than any protein and resistant to protein digestion; he named it nuclein and guessed that a whole family of such molecules might exist. The guess was forgotten. By the early 1950s researchers spoke confidently of the gene as the unit of heredity yet could not say what one looked like or how it was copied. Oswald Avery had shown in 1944 that it was DNA, not protein, that carried hereditary character in pneumococcus, but many held the molecule too monotonous - a backbone of four repeating units - to encode the intricacy of a living thing; the genetic material, they reasoned, surely had to be protein, with its twenty amino acids and endless variety. Crick and Watson grasped early that the three-dimensional shape of the gene was the central problem of the new biology, and that without it heredity could not be understood. They seized it at their first meeting, in 1951, and held to it with a single-mindedness that required them to absorb genetics, biochemistry, physical chemistry, and X-ray crystallography at once. Several disconnected results lay waiting to be joined. Alexander Todd had established that the molecular backbone was a regular chain of alternating phosphate and deoxyribose sugar. Erwin Chargaff had found that, however widely the proportions of the four bases varied between species, adenine and thymine always occurred in equal amounts, as did cytosine and guanine. Maurice Wilkins and Rosalind Franklin, at King's College London, had obtained X-ray fibre photographs pointing to a regular helical form. And Linus Pauling, the foremost structural chemist of the age, had not only discovered the single-stranded alpha helix in proteins but pioneered the method - building scale models constrained by known bond lengths and angles - by which Watson and Crick would work. Pauling supplied the spur as well as the tool: in February 1953 he proposed his own structure for DNA, a three-stranded helix with the phosphates at the core, and Watson and Crick, who could see at once that it was electrostatically impossible, feared being overtaken by the only rival capable of beating them. The paper opens by dismissing it, and sets aside in passing a further three-chain model that Bruce Fraser had drafted at King's but never properly published. The decisive correction came from across the office. Jerry Donohue, a visiting American physical chemist sharing the room, told Watson that the textbook forms of two of the bases were wrong: thymine and guanine should be drawn in their keto, not their enol, configuration. Shifting a single hydrogen atom on each accordingly, Watson cut fresh cardboard models and, moving them about his desktop in late February 1953, saw that an adenine-thymine pair and a cytosine-guanine pair had the very same shape and could be held together by hydrogen bonds. At a stroke this accounted for Chargaff's equalities, fitted the bases neatly between the two backbones demanded by the X-ray evidence, and required the chains to run antiparallel. The published paper states its central implication with a now-celebrated restraint - it had 'not escaped our notice' that the pairing at once suggested how the molecule might be copied: part the two strands, and each serves as the template for a new partner. By the account of Watson's memoir, Crick announced to the lunchtime drinkers at The Eagle that they had found the.…

Hardcover. Condition: Very Good. Dust Jacket Included. 1 leaf, xvi, 226 pp; illus. Original cloth. Swedish postage stamp honoring Crick, Watson, and Wilkins for the Nobel Prize in 1962 is pasted to title page. Wilkins's inscription is partly on the stamp. Very Good, in dust jacket. Third Impression of British Edition. The following pages are signed or annotated: 1. Title page: SIGNED BY NOBEL LAUREATES JAMES D. WATSON, FRANCIS CRICK, MAURICE WILKINS ("with best wishes/ Maurice Wilkins/ April 2003"), AND BY RAYMOND GOSLING. 2. p. 214: SIGNED BY FRANCIS CRICK AND JAMES D. WATSON UNDER THE PHOTOGRAPH SHOWING THEM STANDING BY THEIR DNA MODEL (opposite p. 214). 3. p. 18 SIGNED BY MAURICE WILKINS UNDER HIS PHOTOGRAPH (opposite p. 18). 4. Annotated by Raymond G. Gosling about Rosalind Franklin (under her photograph opposite p. 70): "She had wonderfully lustrous dark eyes. I found her very attractive, as did most everyone who worked with her. She had a strong personality and did not suffer fools gladly. Her powers of concentration were quite fierce and she could get done in a day what other people might have taken several to achieve. Raymond Gosling Sept. 2003". 5. Annotated by Raymond G. Gosling about X-ray photograph of crystalline DNA in the A form (under photograph opposite p. 72): "The pattern that 'kick started' the whole story. A multifibre (about 35) specimen made by Wilkins & myself and taken on a conventional Rayniax tube in the basement of King s College London. This pattern was one shewn by Maurice at the Naples meeting. The A form was obtained serendipitously by my regulating the Hydrogen into the camera by bubbling thru' water--hence ~92% RH. Raymond Gosling. Sept. 2003." 6. Annotated by Raymond G. Gosling about X-ray photograph of DNA in the B form, taken by Rosalind Franklin late in 1952 (under photograph opposite p. 169): "As Rosalind's assistant I actually 'took' this X-ray pattern. Since we were working closely together the overall strategy was Rosalind's. Therefore the importance attributed to some--as to who 'took' the photograph--is inappropriate. R G Gosling Sept. 2003." NOTE: I have included photos of everything signed or annotated, except for Maurice Wilkins's signature under his photo (opposite p. 18). I have a photo of that signature, too. Signed by Author(s).…

First Edition. WATSON, James; CRICK, Francis; WILKINS, M.H.F; FRANKLIN, Rosalind; et al. "A Structure for Deoxyribose Nucleic Acid" (171: 737-38); WITH: "Molecular Structure of Deoxypentose Nucleic Acids" (171:738-40); WITH: "Molecular Configuration in Sodium Thymonucleate" (171: 740-41); WITH: "Genetical Implications of the Structure of Deoxyribonucleic Acid" (171: 964-67); WITH: "Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate" (172: 156-57); WITH: "Heterogeneity of Deoxyribonucleic Acids" (172: 339-42). FROM: Nature: A Weekly Journal of Science, Volumes 171 and 172, January 3, 1953 to December 26, 1953. London: Macmillan and Co., (1953). Thin octavo, disbound, modern stiff paper wrappers. $8800.Six articles extracted from Volumes 171 and 172 of Nature, including the first appearance of the article announcing the most important biological discovery of the 20th century, as well as five follow-up articles further establishing the structure and function of DNA. In these articles in the journal Nature, the most important biological discovery of the 20th century is calmly announced and concisely elucidated in a paper little more than a page long: the key to the deciphering of the genetic code. "It has not escaped our notice," write Watson and Crick near the end of the first paper, "that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material." Neither did it escape the notice of the Nobel Prize committee. In 1962 Crick, Watson and Wilkins received the Nobel Prize in Medicine "for their discoveries concerning the molecular structure of nuclear acids and its significance for information transfer in living material" (Garrison & Morton 256.3; 256.4). Rosalind Franklin mayÑand surely shouldÑhave been included in the award as well were it not for her early death in 1958. These papers document the birth of a new science, Molecular Biology, whose benefits for humanity we are only now beginning to realize. Dibner 200. Grolier Club, One Hundred Books Famous in Medicine, 99. Garrison & Morton 256.3, 256.4. Closely bound, with tight inner margins. Text fine. …

First edition, the three-paper offprint issue, of the primary record of the co-discovery of the molecular structure of DNA. This copy is from the library of Professor Hans Gustav Boman (1924-2008), the leading molecular biologist in Sweden; his signature is in ink on the first page. Three research groups independently investigated the structure of DNA in England in the early 1950s: Francis Crick and James Watson at the Cavendish Laboratory in Cambridge and two teams at King's College, London comprising Maurice Wilkins, Rosalind Franklin, Raymond Gosling, Alec Stokes, and Herbert Wilson. To acknowledge the simultaneity of the discovery, the directors of the respective institutions agreed that the three resulting papers would be published under the general title Molecular Structure of Nucleic Acids in the British scientific weekly Nature. Crick and Watson's paper, "A Structure for Deoxyribose Nucleic Acid", is illustrated with a schematic drawing by Odile Crick of the twisted-ladder structure of DNA, now famously known as the double helix. Wilkins, Stokes, and Wilson co-wrote "Molecular Structure of Deoxypentose Nucleic Acids", the second paper. Franklin and her research student Gosling submitted "Molecular Configuration in Sodium Thymonucleate", which features a halftone illustration of Gosling's iconic X-ray "Photograph 51" of crystallized DNA. Franklin died four years before the Nobel Prize in Physiology or Medicine was awarded to Crick, Watson, and Wilkins in 1962 for their work on DNA, but without question her "contributions, and indeed her actual X-ray data, were crucial to the total achievement" (ODNB). "Two offprints exist of Watson and Crick's paper: a single sheet containing the Watson and Crick article only, and a fourteen-page pamphlet containing the papers of all three research groups. The pamphlet pages are smaller in size than the single leaf, which has the same dimensions as the leaves of the journal, and the layout is different, the single-leaf offprint being printed in two columns like the journal, the pamphlet in single-column pages. The page breaks are different in each of the two offprints and the journal, as is the placement of the illustrations relative to the text. Despite these differences, all three versions appear to have been printed from the same setting of type, except that in the two offprints one paragraph of text has been reset to accommodate the placement of the diagram of the DNA molecule" (Grolier, p. 363). Haskell F. Norman discusses the difficulty in establishing priority between the two formats in his introduction to One Hundred Books Famous in Medicine and closes by stating that "it is now our tentative conclusion that the three-paper offprint is the first issue" (p. xxi). Boman "was one of the pioneers in the field of molecular biology in Sweden" (Norrby, p. 11). After teaching at Uppsala University he transferred to Umeå University to establish their microbiology department; under his leadership it became an international hub of research excellence. "Halfway through his career Boman moved on to Stockholm University and initiated a completely new line of research. It pioneered the development of insights into the emerging field of natural immunity. He developed this work in collaboration with Swedish colleagues and coined the term cecropines for this new kind of peptide antibiotics. This was a Nobel-class discovery" but - like Franklin - Boman died before he could see his research recognized as such (Norrby, p. 11). In 2011, his work formed the basis of a discovery by Jules Hoffman and Bruce Beutler, for which they received the Nobel Prize in Physiology or Medicine. Garrison-Morton 256.3 (Crick and Watson's paper); Grolier, One Hundred Books Famous in Medicine, 99; Heirs of Hippocrates 2342. Erling Norrby, Nobel Prizes: Cancer, Vision and the Genetic Code, 2019. Octavo, pp. 14. With 4 illustrations. Printed pamphlet, wire-stitched as issued. A few neat red pencil marks to first three pages, lower outer corners creased: a near-fine copy.…

First edition of this collection of Nobel Lectures in physiology or medicine from the years 1942-1962. Thick Octavo, original yellow cloth. Signed by all three Nobel Prize-winning scientists Francis Crick, James D. Watson and Maurice Wilkins on the title page. They were awarded the Nobel Prize in Medicine in 1962, "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material."Fine in a very good dust jacket with some closed tears and toning to the spine. An exceptional piece signed by these Nobel Prize-winning scientists. In the early 1950s, the race to discover DNA was on. At Cambridge University, graduate student Francis Crick and research fellow James Watson had become interested, impressed especially by Pauling's work. Meanwhile at King's College in London, Maurice Wilkins (b. 1916) and Rosalind Franklin were also studying DNA. The Cambridge team's approach was to make physical models to narrow down the possibilities and eventually create an accurate picture of the molecule. The King's team took an experimental approach, looking particularly at x-ray diffraction images of DNA. Watson and Crick took a crucial conceptual step, suggesting the molecule was made of two chains of nucleotides, each in a helix as Franklin had found, but one going up and the other going down. Crick had just learned of Chargaff's findings about base pairs in the summer of 1952. He added that to the model, so that matching base pairs interlocked in the middle of the double helix to keep the distance between the chains constant. Watson and Crick showed that each strand of the DNA molecule was a template for the other. During cell division the two strands separate and on each strand a new "other half" is built, just like the one before. This way DNA can reproduce itself without changing its structure -- except for occasional errors, or mutations. The structure so perfectly fit the experimental data that it was almost immediately accepted. DNA's discovery has been called the most important biological work of the last 100 years, and the field it opened may be the scientific frontier for the next 100.…

Original photograph from the 1962 Nobel Prize Ceremony signed by Francis Crick, James Watson, and Maurice Wilkins (jointly awarded the 1962 Nobel Prize in Physiology and Medicine) as well as Max Ferdinand Perutz and John Kendrew (jointly awarded the 1962 Nobel Prize in Chemistry). Also captured in the photograph is John Steinbeck, who was awarded the 1962 Nobel Prize in Literature. In fine condition. The Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material." In 1968, Watson published The Double Helix: A Personal Account of the Discovery of the Structure of DNA, his account of his codiscovery (along with Francis Crick) of the structure of DNA. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).…