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Published by Weinheim : Wiley-VCH-Verl., 2008
ISBN 10: 3527320938 ISBN 13: 9783527320936
8° kart. Condition: Sehr gut. 2., completely rev. ed. XL, 355 S. : graph. Darst. ausgeschiedenes Bibliotheksexemplar, sehr guter Zustand. B05-04-06H Sprache: Englisch Gewicht in Gramm: 1886.
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Published by John Wiley & Sons Inc, New York, 2009
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First Edition
Hardcover. Condition: new. Hardcover. Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applicationsThe number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new publications a yearCovers basic chemistry as well as state-of-the-art applications in life science and materials scienceWorld-ranked authors describe their own research in the wider context of azide chemistryIncludes a chapter on safe synthesis and handling (azides can decompose explosively) In the past decade, completely new perspectives have been developed for the use of azides in peptide chemistry, combinatorial chemistry, and heterocyclic synthesis. The world-ranked authors of Organic Azides describe their own research in the wider context of azide chemistry and include a vital chapter on safe synthesis and handling. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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Published by Royal Society of Chemistry, 2015
ISBN 10: 1782620303 ISBN 13: 9781782620303
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Published by Royal Society of Chemistry, Cambridge, 2015
ISBN 10: 1782620303 ISBN 13: 9781782620303
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Hardcover. Condition: new. Hardcover. One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly undruggable proteins. Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences. This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.