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Published by Morgan & Claypool Life Sciences, 2018
ISBN 10: 1615047840 ISBN 13: 9781615047840
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Über den AutorJulien Berro, Ph.D., is an assistant professor of Molecular Biophysics and Biochemistry, and of Cell Biology at Yale University. He initially trained in Physics, Applied Mathematics and Computer Sciences at the Institu.
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Published by Morgan & Claypool Publishers, 2018
ISBN 10: 1615047867 ISBN 13: 9781615047864
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Published by Morgan & Claypool Life Sciences, 2018
ISBN 10: 1615047840 ISBN 13: 9781615047840
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Clathrin-mediated endocytosis (CME) is a ubiquitous internalization process in eukaryotic cells. It consists of the formation of an approximately 50-nm diameter vesicle out of a flat membrane. Genetics, biochemistry, and microscopy experiments performed in the last four decades have been instrumental to discover and characterize major endocytic proteins in yeast and mammals. However, due to the highly dynamic nature of the endocytic assembly and its small size, many questions remain unresolved: how are endocytic proteins organized spatially and dynamically How are forces produced and how are their directions controlled How do the biochemical activities of endocytic proteins and the membrane shape and mechanics regulate each other These questions are virtually impossible to visualize or measure directly with conventional approaches but thanks to new quantitative biology methods, it is now possible to infer the mechanisms of endocytosis in exquisite detail. This book introduces quantitative microscopy and mathematical modeling approaches that have been used to count the copy number of endocytic proteins, infer their localization with nanometer precision, and infer molecular and physical mechanisms that are involved in the robust formation of endocytic vesicles.
Language: English
Published by Morgan & Claypool Life Sciences, 2018
ISBN 10: 1615047867 ISBN 13: 9781615047864
Seller: moluna, Greven, Germany
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Über den AutorJulien Berro, Ph.D., is an assistant professor of Molecular Biophysics and Biochemistry, and of Cell Biology at Yale University. He initially trained in Physics, Applied Mathematics and Computer Sciences at the Institu.