Ann M Dvorak (38 results)

Hardcover. Condition: Very Good. No Jacket. 3805578644. Ex lib. hardcover. Bump on one corner. Contents as new. 351 pages, index, illustrated with photos, charts and diagrams. Reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. The secretory granules and lipid bodies present in these cells are established as different, important organelles. A number of standard and newly developed ultrastructural imaging methods are described which define the subcellular locations of chymase, Charcot-Leyden crystal protein, histamine, and heparin as well as materials important in arachidonate and RNA metabolism, and in cytokine biology in basophils and mast cells. The findings presented elucidate new aspects of the secretory mechanisms of basophils and mast cells, their recovery, and the transepithelial route of passage of macromolecules stimulated by permeability mediators released from these cells. Including more than 180 excellent micrographs. Contents clean, tight and bright. Book.…

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Condition: New. 1 Introduction.- 2 Ultrastructure of Human Mast Cells.- 3 Ultrastructure of Human Basophils.- 4 In Vitro Studies of Human Mast Cells.- 4.1 Human Mast Cell Granules and Lipid Bodies.- 4.1.1 Differences in Structure.- 4.1.2 Differences in Content.- 4.1.3 Diff.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - 8 References . 95 Subject Index 101 VIII 1 Introduction Mast cells and basophils were first described by Ehrlich (1877, 1878, 1879). Although these cells share many functional properties, they can readily be distinguished using morphological criteria (Dvorak 1986a; Dvorak et al. 1983a, 1983c; Galli et al. 1984). The identification of immunoglobulin E (IgE) and high affinity IgE receptors on mast cells and basophils was instrumental to our understanding of the mechanisms underlying the role of these cells in immediate hypersensitivity reactions (Ishizaka and Ishizaka 1979; Ishizaka et al. 1966, 1972, 1973; Tomioka and Ishizaka 1971). We now know that these IgE-mediated mechanisms as well as a number of other stimuli can cause the rapid release of many preformed mediators of inflammation from both mast cells and basophils (Galli et al. 1984). The most well-known of these is histamine. Potent mediators that are not preformed are also stimulated and released from these cells. Recently, products of arachidonic acid metabolism, such as the prostaglandins and leukotrienes, have been found to be generated either by the cyclooxygenase pathway or the lipoxy genase pathway in mast cells and basophils (Lewis and Austen 1981, 1984; Peters et al. 1984, 1987). Detailed studies and reviews of the biochemistry of these mediators and their immunologically mediated reactions have been published (Lewis and Austen 1981, 1984; Lichtenstein et al. 1979; MacGlashan et al. 1982b; Paterson et al. 1976; Peters et al. 1984, 1987). Mast cells and basophils contain other important biochemicals.…

Condition: New. pp. vii + 107.

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Hardcover. Condition: Very Good. Sorry, No international shipping on this item.Ex-Library hardcover in very nice condition with all the usual markings and attachments. Sunned spine. Text block clean and unmarked. Tight binding.

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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.…

Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.…

Condition: New. pp. 424.

Paperback. Condition: Brand New. reprint edition. 423 pages. 9.61x6.69x0.96 inches. In Stock.

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Condition: Used. pp. 416.

Condition: Used. pp. 416.

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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -8 References . 95 Subject Index 101 VIII 1 Introduction Mast cells and basophils were first described by Ehrlich (1877, 1878, 1879). Although these cells share many functional properties, they can readily be distinguished using morphological criteria (Dvorak 1986a; Dvorak et al. 1983a, 1983c; Galli et al. 1984). The identification of immunoglobulin E (IgE) and high affinity IgE receptors on mast cells and basophils was instrumental to our understanding of the mechanisms underlying the role of these cells in immediate hypersensitivity reactions (Ishizaka and Ishizaka 1979; Ishizaka et al. 1966, 1972, 1973; Tomioka and Ishizaka 1971). We now know that these IgE-mediated mechanisms as well as a number of other stimuli can cause the rapid release of many preformed mediators of inflammation from both mast cells and basophils (Galli et al. 1984). The most well-known of these is histamine. Potent mediators that are not preformed are also stimulated and released from these cells. Recently, products of arachidonic acid metabolism, such as the prostaglandins and leukotrienes, have been found to be generated either by the cyclooxygenase pathway or the lipoxy genase pathway in mast cells and basophils (Lewis and Austen 1981, 1984; Peters et al. 1984, 1987). Detailed studies and reviews of the biochemistry of these mediators and their immunologically mediated reactions have been published (Lewis and Austen 1981, 1984; Lichtenstein et al. 1979; MacGlashan et al. 1982b; Paterson et al. 1976; Peters et al. 1984, 1987). Mast cells and basophils contain other important biochemicals. 120 pp. Englisch.…

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -1 Introduction.- 2 Ultrastructure of Human Mast Cells.- 3 Ultrastructure of Human Basophils.- 4 In Vitro Studies of Human Mast Cells.- 4.1 Human Mast Cell Granules and Lipid Bodies.- 4.2 Anaphylactic Degranulation of Human Lung Mast Cells In Vitro.- 4.3 Recovery from Anaphylactic Degranulation of Human Lung Mast Cells In Vitro.- 5 In Vivo Studies of Human Mast Cells.- 5.1 Anaphylactic Degranulation of Human Mast Cells In Vivo.- 5.2 Piecemeal Degranulation of Human Mast Cells In Vivo.- 5.3 Activated Human Mast Cells Have Increased Lipid Bodies.- 5.4 Mast Cell Shedding.- 6 Mast Cell Morphologic Cycles.- 6.1 In Vitro.- 6.2 In Vivo.- 7 Concluding Remarks.- 8 Summary.- References.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 120 pp. Englisch.…

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Condition: New. Print on Demand pp. vii + 107 89 Figures.

Condition: New. PRINT ON DEMAND pp. vii + 107.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well. 424 pp. Englisch.…