Pan-genomics: Applications, Challenges, and Future Prospects
Language: English
Published by Academic Press, 2020
- First Edition
- Softcover
- Used
Seller: killarneybooks, Inagh, Clare, Irelandkillarneybooks
AbeBooks seller since April 20, 2017
Condition: Used - Good
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Add to basketItem description from seller
Oversized paperback, xxiv + 450 pages, NOT ex-library. Weight over 1kg. 2 first pages not bound in (manufacturing fault); a corner crease on the front cover, gentle rubbing to cover edges, external shelfwear. Interior is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Spine remains free of creasing. Good+ condition. -- This edited volume provides a comprehensive treatment of pan-genomics, the study of the entire gene repertoire of a species or taxonomic group rather than a single reference genome. The field emerged from the recognition that no single genome can capture the full genetic diversity within a species, and that genes present in some strains or individuals but absent from the reference sequence - the so-called dispensable or accessory genome - often carry critical information about adaptation, virulence and drug resistance. The contents are organised around three axes indicated by the title. Opening chapters address the conceptual foundations and bioinformatics approaches applied in pan-genomic analysis, including the computational tools required to construct, annotate and query pan-genomes from large-scale sequencing data. A substantial portion of the book focuses on bacterial comparative genomics, where pan-genomic methods have had their most mature application, leveraging these approaches for the development of precise diagnostics, vaccines and drug targets. The text presents twelve specific case studies covering a diverse range of organisms, including human pathogens (Corynebacterium), veterinary and plant pathogens, and model bacteria. The coverage extends beyond microbiology into plant genomics, human genetics (including pan-cancer analysis), and the pan-genomics of fungi, algae and viruses. This reflects the broadening scope of pan-genomic methods as sequencing costs have fallen and long-read technologies such as PacBio and Oxford Nanopore have improved the resolution of complex and repetitive genomic regions. Chapters address the transition from linear reference genomes to graph-based representations capable of encoding structural variation, copy number differences and presence-absence variation across populations. The computational challenges receive sustained attention, including the storage and processing of datasets that can reach petabyte scale, the development of efficient algorithms for sequence alignment against graph genomes, and the functional annotation of variable genes absent from reference sequences. Final sections explore the emerging integration of pan-genomics with other 'omics' layers, such as pan-transcriptomics, pan-proteomics and pan-metabolomics, to provide a multi-dimensional view of species.…
Seller Inventory # 008654
- Title
- Pan-genomics: Applications, Challenges, and Future Prospects
- Author
- Debmalya Barh; Siomar Soares; Sandeep Tiwari; Vasco Azevedo
- Publisher
- Academic Press
- Publication year
- 2020
- Condition
- Good
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 012817076X
- ISBN 13
- 9780128170762
- Edition
- 1st Edition
Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics, encompasses the developments on omics studies to be applied on bacteria related studies.
This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health.
- Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives
- Discusses current bioinformatics tools and strategies for exploiting pangenomics data
- Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability
"Synopsis" may belong to another edition of this title.
About the Author
Dr Soares holds a degree in Biomedicine, with special training in Bioinformatics, Master's Degree and PhD in Genetics by Federal University of Minas Gerais – UFMG, the latter with one year of study at the Center for Biotechnology (CeBiTec), Universität Bielefeld. He holds a Post-doctorate in Bioinformatics by UFMG. He was Senior Researcher Bioinformatics at the Central Official Laboratory of the Brazilian Ministry of Fisheries and Aquaculture (2014-2015). He is currently Professor at Federal University of the Triângulo Mineiro (UFTM) since 2015, Secretary of the Southeastern regional of the Brazilian Society of Genetics (2017-current), Substitute Coordinator of the undergraduate course in Biomedicine at UFTM (2017-current) and Substitute Research and Technology Development Coordinator of UFTM (2017-current). His research interests are molecular genetics, genomic sequencing and comparative genomics of microorganisms, focusing on pan-genomics, genomic plasticity in the identification of islands of pathogenicity and virulence factors, phylogenomics, molecular epidemiology, reverse vaccination and software development.
Dr. Tiwari obtained his BSc from Deen Dayal Upadhyaya Gorakhpur University, MSc in bioinformatics from Devi Ahilya University, and PhD in bioinformatics from the Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Brazil. He is a Guest Associate Editorial Board of Frontier in Genetics and frequently serves as an external reviewer for PeerJ and Frontiers. His main areas of expertise are molecular genetics, genomic sequencing, and comparative genomics of microorganisms, with a focus on pan-genomics, genomic plasticity in the identification of pathogenicity islands and virulence factors for drug discovery, phylogenomic, molecular epidemiology, reverse vaccinology, and immunoinformatic.
Dr. Vasco Azevedo is a full professor at the Department of Genetics, Ecology, and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. He is a CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) researcher 1A, member of the Brazilian Academy of Sciences, Commander of the Order of Scientific Merit of the MCTI of the genetics advisory committee and the public policy working group on biotechnology and genetic resources of COBRG/CNPq, coordinator of the Associated International Laboratory Bactinfl from INRAE and UFMG, and vice-president of the Brazilian Association of Bioinformatics and Computational Biology. He holds a degree in veterinary medicine from the School of Veterinary Medicine of the Federal University of Bahia (1986), a master's degree (1989), a doctorate (1993) in the genetics of microorganisms from the Institut National Agronomique Paris Grignon, and a doctorate in bioinformatics from UFMG (2017). He did his postdoctorate work with the Department of Microbiology, School of Medicine, University of Pennsylvania, United States (1994). He was a professor at the Institute of Biomedical Sciences of the University of São Paulo (2004). He is an expert in genetics and bioinformatics and his work mainly focuses on genomics, transcriptomics, proteomics, metabolomics, vaccine development, diagnostics, and the development of next generation probiotics. He has more than 600 scientific publications, 14 books, and 60 chapters as well as 12 patents.
"About the title" may belong to another edition of this title.
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