Virus Interference Interferon by Isaacs Lindenmann (2 results)

Series: Proceedings Royal Society, London. Series B, Biological Sciences, vol. 147, no 927, 1957. 8vo. pp. 258-267. Original printed wrappers. FINE. This is the original paper which outlined the discovery, long searched for, of what was called 'interferon.' ". . .in 1937. . . George W. M. Findlay and F. O. MacCallum, who observed that monkeys infected with Rift Valley Fever virus resisted the fatal, antigenetically distinct, yellow fever virus. Reports of interference among other viruses appeared, and in 1943 Werner and Gertrude Henle discovered that ultraviolet- or heat-killed viruses are still able to interfere with secondary inoculations of live viruses. The scientific literature was soon filled with speculations on mechanisms for this transient form of viral immunity that apparently involved neither antibody not phagocyte. The discovery and premier analysis of the agent came in 1957 with Alick Isaacs and Jean Lindenmann." Also in this issue, Virus interference II: Some properties of interferon, pp. 268-273. Bibel, Debra Jan, Milestones in Immunology, pp. 208-212; Garrison-Morton 2578.22.…

Isaacs, Alick (1921-1967) & Lindemann, Jean (1924- ). Virus interference. I. The interferon. In: Proc. Roy. Soc., series B, 147 (1957): 258-67. Whole number, 8vo. 145-273pp. 3 plates, fold. table. 254 x 172 mm. Original printed wrappers. Fine copy. First Edition. Garrison-Morton 2578.22. Isaacs and Lindemann discovered interferon in 1956 while investigating the influenza virus: they found that chick embryos injected with the virus produce minute amounts of a protein that destroys the invading virus and increases resistance to other viral infections. Interferon was at first hailed as a major breakthrough in the treatment of viral infections, but the difficulty and expense of its production at the time discouraged further research until the late 1960s, when interferon's value as a weapon against cancer and certain viral diseases was discovered, and ways were found to manufacture it more economically. Porter, Biographical Dictionary of Scientists, pp. 362-63. .…