Identifying Genes Encode App by Zhang (6 results)
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Taschenbuch. Condition: Neu. Identifying Genes That Encode APP Metabolism Modulators | A novel approach in functional genomics to gain insight into the pathogenesis of Alzheimer's disease | Can Zhang | Taschenbuch | 156 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838360898 | Verantwortliche Person für die EU…: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.
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Language: English
Published by LAP LAMBERT Academic Publishing Apr 2010 2010
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Alzheimer s disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta prec…ursor protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this 'translational' study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel APP metabolism regulators. We have identified 11 positional candidate genes in an AD risk linkage region on chromosome 9 where the AD candidate gene, ubiquilin 1 (UBQLN1), has been previously found. Our data also showed that UBQLN1, which encodes a protein involved in protein degradation and quality control, modulates APP metabolism through a cell type-dependent mechanism. Collectively, we report a novel approach in functional genomics that provides a robust tool to identify novel AD candidate genes and may serve to provide insight into the pathogenesis of AD. 156 pp. Englisch.
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Zhang CanDr. Can Zhang is currently a research fellow at Harvard Medical School and Massachusetts General Hospital after earning his M.D. and Ph.D. His research background includes a wide range of field…s, including neurodegenerative .
Language: English
Published by LAP LAMBERT Academic Publishing Apr 2010 2010
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Alzheimer''s disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta precurs…or protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this 'translational' study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel APP metabolism regulators. We have identified 11 positional candidate genes in an AD risk linkage region on chromosome 9 where the AD candidate gene, ubiquilin 1 (UBQLN1), has been previously found. Our data also showed that UBQLN1, which encodes a protein involved in protein degradation and quality control, modulates APP metabolism through a cell type-dependent mechanism. Collectively, we report a novel approach in functional genomics that provides a robust tool to identify novel AD candidate genes and may serve to provide insight into the pathogenesis of AD.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 156 pp. Englisch.
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Alzheimer s disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta precursor… protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this 'translational' study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel APP metabolism regulators. We have identified 11 positional candidate genes in an AD risk linkage region on chromosome 9 where the AD candidate gene, ubiquilin 1 (UBQLN1), has been previously found. Our data also showed that UBQLN1, which encodes a protein involved in protein degradation and quality control, modulates APP metabolism through a cell type-dependent mechanism. Collectively, we report a novel approach in functional genomics that provides a robust tool to identify novel AD candidate genes and may serve to provide insight into the pathogenesis of AD.
