springer us chapman and hall crc mär 2012 (118 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -On Revolutions That Never Were 'If you want to understand what a science is,' the anthropologist Clifford Geertz (1973, p. 5) has written, 'you should look in the first instance not at its theories or its findings, and certainly not at what its apologists say about it; you should look at what the practitioners of it do. ' If it is not always possible to follow this instruction, it is because the rate of change in scientific work is rapid and the growth of publications reporting on this work is great. It is therefore the task of a handbook, like this Hand book of Political Behavior, to summarize and evaluate what the practi tioners report. But it is always prudent to keep in mind that a handbook is only a shortcut and that there is no substitute for looking directly at what the practitioners of a science do. For when scientists are 'at work' (Walter, 1971), the image of what they are doing is often quite different from that conveyed in the 'briefs' that, in their own way, make a hand book so valuable that we cannot do without it. These reflections set the stage. 392 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As the systems which form the fabric of modern society become more complex and more interdependent, the need for the understanding of the behavior of such systems becomes increasingly more essential. What are the causes and possible cures for the worldwide inflation which is posing a serious threat to the economic stability and social order of both developed and underdeveloped countries What are the trade-offs between the urgent need for additional sources of energy and the risks posed by the proliferation of nuclear reactors How can one devise mass transportation systems which are fast, comforta ble, convenient, and yet not prohibitively expensive These issues are but some of the more visible problems posed by what might be called the crisis of undercoordination--a crisis rooted in the widen ing gap between the degree of interdependence in the systems of modern society and the degree of coordination which libertarian societies are willing to tolerate. The disquieting implication of this crisis is that to achieve stability through coordination may necessitate the imposition of pervasive controls which may be hard to accept by societies steeped in the democratic tradition. Viewed in this perspective, the need for developing a better understanding of the behavior of large-scale societal systems presents a problem of much more than purely academic importance. 428 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The end of the Second World War marked the beginning of a new era in the history of the Nederlandsche Bank. The change was clearly reflected in the revision of the Bank Act in 1948 and the take-over of the Bank's share capital by the Government in the same year. The revised Bank Act stresses the importance of the Bank's monetary duties, which are 'to regulate the value of the Netherlands monetary unit in such a way as is deemed most conducive to the welfare of the country, and therewith to stabilize that value as far as possible' a truly Herculean task, particularly in the turbulent years following the war. However ceremonious the language used in formulating these duties, their meaningful performance required a dynamic leader. It was Dr. Marius W. Holtrop who shouldered the task. From his appointment to the day of his retirement he devoted himself to the implementation of monetary policy. But he also went beyond the confines of his immediate duties in that he gave much attention to laying the theoretical foundations for such a policy. 432 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume marks the first of a new series, Contemporary Geriatric Medicine, joining the ever growing 'Contemporary' family. As with the other 'Contem porary' volumes, our goal is to assist the reader in maintaining currency in a rapidly changing field. Perhaps no field has shown such major advances in such a short time as geriatrics. Over the last several years, the 'demographic impera tive' has become a source of concern for many, including clinicians, scientists, econ omists, and health planners. Our geriatric knowledge base continues to grow, often making it difficult to keep abreast of advances and current therapeutic modalities. Contemporary Ger iatric Medicine presents the state-of-the-art thinking regarding a variety of topics all of major concern to the health practitioner caring for the elderly person. The authors, for the most part serving as members of a stable editorial board, have chosen topics that should have immediate interest to the readership. By having a stable editorial board, continuity is ensured in successive volumes. Every two years, a subsequent issue will either address new thoughts on already presented topics or focus on new topics of current interest. As with the other 'Contempo rary' series volumes, the every other year interval is intended to allow new find ings to develop and be tested. It also provides the authors with time to provide the highest quality of work. 440 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses. 500 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Even when one is willing to estimate the various loss coefficients in a given system, it is not always an easy matter to determine the flow rate and/or the total pressure drop across the system. While there are gas dynamics books that contain Fanno tables which involve flow with losses, such tables are never specific; that is, the conventional tabulations are never given in terms of specific loss coefficients or specific total pressure ratios. The tables contained in this book are unique in this respect. The user can establish from these tables not only the various state point functions, but the total pressure losses as well. (The total pressure ratio is shown to be the only true indica tion of loss in a flow system.) Both compressible and constant-density solutions are presented. Tables for fluids of various ratios of specific heats are included. Use of these tables is not restricted to constant-area systems, nor does their use require iterative procedures. For compressible flows, tables of solutions for both the subsonic and supersonic regimes are given. The loss coefficients obtained from these tables are unique in that they are shown to be additive in series systems. This permits the investigator to evaluate a flow system either as a series of components or in its entirety. 204 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the growing realization that pain and its control are vital areas for both theoretical and practical research as well as clinical treatment has come the desire for an assessment of the state-of-the-art. Pain research by itself is not new. Yet, approaches to the study and control of pain are new. This book is based upon a symposium-workshop on the study and control of pain that took place at the annual meeting of the American Association for the Advance ment of Science, January, 1975. It was destgned to deal with a number of theoretical and clinical issues. We at tempted to assess previous years of research, how conceptions of pain phenomena have changed and what are some of the gaps in our knowledge. Presentations were also geared to show our increased methodological sophistication. Clinically, we have also changed our treatment conceptualization of pain control. We have not merely added a few 'tricks' to deal with pain. Entirely new approaches are now available. View ing pain as a public health problem we find many areas of needed research that should be directed toward the epidemio logy of pain, the reduction of fear of obtaining health care, and unmet treatment needs. Obviously, this book cannot provide full, comprehensive treatment of all the issues involved. It can, however, pro vide the reader with an understanding of the current, major thrusts, new research and treatment goals in pain control. 240 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -English-speaking scientists start with one vast advantage: the bulk of the world's scientific transactions are conducted in English. There are many who would go further and say that any scientific work of importance is published in English. This book, which is, in effect, the tip of a large iceberg, gives them the lie! In the Soviet Union alone we have a vast wealth of expertise supported by a treasury of books and publications, but it is effectively cut off from Western scrutiny by the language barrier. It therefore seems timely to lift the curtain a little and put some of the best of it on display. In this excellent compilation, Professor Valdman and Dr. Burov have assembled a cast list of leading Soviet scientists who provide us with a refreshingly different slant on a set of problems of con cern to neuroscientists throughout the world. These scientific presentations are neither better, nor worse than but, rather, com plementary to Western pharmacological thinking. Traditional Soviet approaches to animal psychology are here coupled with sophisticated latter-day neurochemistry and neurophysiology and, in the process, provide us with new insights into the molecular bases of animal responses to environment and to certain drugs. Apart from shedding new light on many contemporary problems, the findings reported here provide an important window on the thought processes of the foremost neuroscientists of the Soviet Union. This book cannot fail to be of interest to all who work in this expanding (and exciting) area. M. 516 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Have a chew of dulie,' said Crubog . . . 'What is it ' asked Potter, half-suspiciously. 'Seaweed. ' 'Is it good for the virility . . . ' 'And what is the virility ' asked the old man. 'Does it make you more attractive to women ' Potier shouted in his ear. 'No. ' 'What is it good for then ' 'WortnS. ' 'Worms ' 'Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. ' 'If it's an anthelmintic, I'll try a spot of it,' said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done. 688 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -All animals show longlasting changes in behaviour as a result of individual experience and this adaptability is one of their most striking features. The changes may be abrupt, radical and permanent. In higher animals it seems reasonable to ascribe their ability to change behaviour to the same physiological process that underlies human behavioural change and memory. The known physiology of the brain gives no clues as to the mechanism. On the contrary, physiological research on the nervous system has relied upon the fact that the reactions of nerve cells studied were stereotyped and could be repeated frequently without modification. Only recently has the deliberate search for modifiable nerve cells begun but nothing yet discovered shows the rapidity, certainty and permanence of a behavioural change in intact animal. (Kandel and Spencer, 1968). Research on memory therefore must combine the accurate observation of animal behaviour, in very well understood situations, and a knowledge of the biology of the brain and of the kind of physiological processes likely to be involved in memory storage. If one is sure that a certain behavioural change does depend uniquely on memories gained during an experiment it is possible, by using likely inhibitors of brain physiology to test the susceptibility of memories to disruption. 568 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recent years have seen great strides in research on the pathogenesis of thromboses, unmatched by progress in other branches of hemostasiology. The orthodox concepts of the mechanisms of thrombus formation described by Virchow have come down to us as a 'classical triad' of factors. Now, due to developments in molecular biology, pharmacology, and patho physiology, they appear in a basically new light. The fruits of modern research, currently being tested or already imple mented in clinical practice, have opened up the possibility of controlling the hemostatic process and developing effec tive antithrombotic drugs. Much progress has been achieved in the past years, but much more remains to be achieved in such areas as the patho genesis of venous and arterial thromboses, early diagnosis, therapy, and control of disorders. Many scientists in the U.S.S.R. are involved in studying these problems. Their data, from years of research carried out in leading laboratories and clinics in the U.S.S.R., are summarized in this monograph. This work is written by experts in various fields of biology and medicine. It deals with new and original con cepts on the structure and function of the fibrinolytic sys tem, the role of nonenzymatic fibrinolysis in regulating physiological hemostasis, the heterogeneous and discrete pat terns of the system regulating blood coagulation, the molecu lar mechanisms of fibrin polymerization, and the anticoagu lating effects of fibrinogen/fibrin degradation products. 444 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Included in the program of The Fourth International Congress of Human Genetics, held in Paris on September ~-ll, 1971, was a Workshop of Genetic Distance. This session, or ganized by Newton E. Morton, included several papers anrl a discussion under the general chairmanship of James F. Crow. Many of the participants and members of the audience asled at the time that the papers be printed so as to have a per manent record. It has not been practical to record the dis cussion, but all the papers originally presented are includ ed in this volume. The idea behind the Workshop was to take advantage of the large number of people who would be attending the Con gress and bring together those who were interested in human population structure and measures of genetic distance. The emphasis was on methodology; the number of metbods almost equals the number of persons working in the field. The Workshop offered an opportunity to present and discuss the various procedures and review their accomplishments. The aim has been to have these papers either present the methods themselves, or give references as to where they can be found. 204 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains the proceedings of a workshop held at Drexel University from September 1 to September 3, 1980, under the joint auspices of Drexel University, The University of Tennessee and Vanderbilt University. The workshop dealt with subjects of topical importance to the nuclear physics community: high spin phenomena, heavy ion reactions, transfer reactions, microscopic theories of nuclear structure and the interacting boson model, and miscellaneous topics. This pro ceedings contains all of the invited papers plus short manuscripts expanding on the materials of the invited papers. A total of about 85 participants came to the workshop. The format of the conference was kept informal on purpose, so as to facilitate the discussions. Unfortunately, these discussions, at times intense, could not be included in this volume due to the lack of secretarial help during the meeting. A great deal of current information was exchanged during the conference. However, the full impact of a conference can only be realized when the proceedings have been published and read by par ticipants as well as other colleagues in this field of physics who were not in attendance. We sincerely hope that these proceedings will be useful in this regard. 608 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Clinical trials are the most definitive tool for evaluation of the applica bility of clinical investigations. The main objective of clinical investiga tions is to assess the potential value of a therapeutic entity in the treat ment or prophylaxis of a disease or a condition. It is also deemed necessary at this stage to obtain information regarding the undesirable side effects, associated risks, and their interrelationship with clinical assessments. Most of these clinical investigations conform, in some form or fashion, to the guidelines adopted by the Food and Drug Administration (FDA) for a given class of compounds. Clinical investigations in the past have not included specific studies in special or subpopulations, e.g., the elderly. Because of an ever-increasing elderly population, newer policies for clinical investigations are now being debated with the recognition of enhanced drug sensitivity in this special population. This key research activity can lead not only to improved health care in the elderly but also to control of its costs. 468 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thjs bibliography had its inception in 1967, when the compilers first attempted a comprehensive cov erage of the finite element literature using both manual and computer-based retrieval. Initially, the data base was stored on a card index, but this was subsequently transferred to punched cards and magnetic tape. Computer processing was adopted at an early stage to derive the three index formats from the data base. Over the subsequent years, several versions of the bibliography were produced, with two of these being made available in a report form to other researchers. From the widespread interest in these documents, it became evident that there was a need for a commercially-available comprehensive bibliography in this area. A major effort was undertaken to revise, update, and extend the data base, resulting in this present volume. The bibliography covers the period 1956-1975 primarily, although some earlier publications of histori cal interest are included. The citations are not restricted to the English language and documents are listed in many languages and from diverse places of origin. All publication formats were accepted, so that references will be found to books, monographs, journal papers and articles, theses, dissertations, reports, surveys, and the like. 696 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Atomic diffusion in metals was first discovered some sixty-five years ago, and since then a considerable wealth of data has ac cumulated on diffusion in various systems. However, work prior to about the year 1940 is now mainly of historical interest, since ex periments were often carried out under experimental conditions and with methods of analysis leading to uncertainties in inter preting the measured diffusion coefficients. Data on diffusion rates are of importance in processes which are controlled by rates of atomic migration such as growth of phases and homogenization of alloys. In addition diffusion plays an important part in theories of such phenomena as oxidation, plastic deformation, sintering, and creep. A tremendous advance in diffusion studies was made possible by the availability of radioactive isotopes of sufficiently high spe cific activity after the second world war. Measurements of self diffusion rates then became possible using radioactive isotopes having the same chemical properties as the solvent material, and it also became possible to study tracer impurity diffusion when the concentration of the impurity is so small as not to alter the chemi cal homogeneity of the system. In the last ten to fifteen years the purity of materials used in diffusion studies has increased con siderably and the methods of analysis have become more stand ardized. 120 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the past five years there has been a reawakening of interest in the psychotherapy of patients with medical disorders characterized as psychosomatic. For three decades, psychoanalysis and psychoanalytic psychotherapy were used extensively to treat and study psychosomatic disorders. Early in the 1960s, interest in this approach to these conditions faded, and the Psychosomatic Service in most hospitals became the Consultation Liaison Service (Lipowski, 1967). The recent focus of biofeedback on psychosomatic conditions provides a new technique with which the physician or psychiatrist may treat these patients (Rickles, 1981). In addition, the successful application of biofeedback training to a variety of complaints such as those presented in this volume has heralded the addition of biofeedback to the treatment modalities used for medical complaints. Frequently, psychological factors can still be seen; for example, when biofeedback treatment may require lifestyle changes on the part of the patient, the exploration of secondary gains or resistances before the disorder can be success fully treated, and the establishment of rapport and empathy which is so important for truly effective biofeedback training. Aside from certain psychological dimensions that are always present in biofeed back training, in this case biofeedback is being used in a primarily medical setting for primarily medical complaints. 260 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book has developed from a short residential course organised by the Department of Minerals Engineering and the Department of Extra Mural Studies of the University of Birmingham. The course was concerned mainly with physical methods of analysis of minerals and mineral products, and particular regard was given to 'non-destructive' methods, with special emphasis on newly available techniques but with a review of older methods and their recent developments included therein. Mineral analysis is obviously of great importance in all the stages of mineral exploration, processing, and utilisation. Selection of a method for a particular mineral or mineral product will depend upon a number of factors, primarily whether an elementary analysis or a phase or structure analysis is required. It will also depend upon the accuracy required. The chapters in the book covering the different methods show the range of useful applicability of the methods considered and should prove valuable as an aid or methods for a given set of circumstances. in selecting a suitable method The book, referring as it does to the majority of the instrumental methods available today (as well as, for comparison, a useful contribution on the place of classical wet chemical analysis) will be valuable to the student as well as to those analysts, research workers, and process engineers who are concerned with the winning, processing, and utilisation of minerals and mineral products. 528 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Paget's disease is an old disease historically, but a new disease therapeutic ally. Human remains unearthed in Lancashire, England, dating from ap proximately 900 AD, show clear evidence of the aftliction. However, it was not until the 1800s that physicians rediscovered the condition, and a little more than 100 years ago that Sir James Paget published a perceptive and accurate description of the disease from the clinical and pathologic points of view. He felt the disease represented an inflammatory condition of the skeleton and hence named it osteitis deformans. The condition again lapsed into anonymity for several decades afterwards, and therapeutic approaches did not evolve until after World War II when several groups, located mainly in the Boston area, began using a variety of agents, includ ing corticosteroids for treatment of this condition. These early attempts at therapy were unsuccessful and the condition remained essentially untreat able until the development of the calcitonins and the bisphosphonates in the 1970s. In 1978, the Paget's Disease Foundation, a private nonprofit volun tary health agency, was founded to assist individuals aftlicted by Paget's disease of bone, to provide education regarding this condition to the medical community, and to encourage research efforts to better under stand and treat the condition. An international conference was organized under the aegis of the Paget's Disease Foundation and was held in New York City in October, 1989, ten years after the founding of the Paget's Disease Foundation. 336 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the past two decades, remarkable advances have been made in psychopharmacology, resulting in increased demands for journal space (witness the large number of journals that cater primarily or exclusively to this topic). Concomitantly, a need developed for more integration of the currently available data. To this end, numerous edited volumes in psycho pharmacology have appeared which have been primarily concerned with the role of a particular drug or system in modulating a wide variety of behaviors. While such texts have been most useful in elucidating drug mechanisms and the etiology of a number of behaviors, few attempts have been made to evaluate and integrate pharmacological treatments within a single behavioral category. Specifically, the researcher interested in understanding a given behavior from a neurochemical point of view must consult several texts, each dealing with a different chemical or system. When texts are obtained covering a broad spectrum of systems, they also invariably deal with many different behaviors, thus not allowing for complete integration within a behavioral category. The present volume was planned to meet the needs of the scientist interested in understanding neurochemical mechanisms underlying aversively motivated behavior, as well as drug effects thereon. In organizing the contents of this text, it quickly became apparent that any attempt to provide a complete overview of behavioral and pharmacological information pertaining to aversive situations was not practical for at least two reasons. 580 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Linear chain substances span a large cross section of contemporary chemistry ranging from covalent polymers, to organic charge transfer com plexes to nonstoichiometric transition metal coordination complexes. Their commonality, which coalesced intense interest in the theoretical and exper imental solid state physics/chemistry communities, was based on the obser vation that these inorganic and organic polymeric substrates exhibit striking metal-like elec,trical and optical properties. Exploitation and extension of these systems has led to the systematic study of both the chemistry and physics of highly and poorly conducting linear chain substances. To gain a salient understanding of these complex materials rich in anomalous aniso tropic electrical, optical, magnetic, and mechanical properties, the conver gence of diverse skills and talents was required. The constructive blending of traditionally segregated disciplines such as synthetic and physical organic, inorganic, and polymer chemistry, crystallography, and theoretical and ex perimental solid state physics has led to the timely development of a truly interdisciplinary science. This is evidenced in the contributions of this monograph series. Within the theme of Extended Linear Chain Compounds, experts in important, but varied, facets of the discipline have reflected upon the progress that has been made and have cogently summarized their field of speciality. Consequently, up-to-date reviews of numerous and varied aspects of 'extended linear chain compounds' have developed. Within these vol umes, numerous incisive contributions covering all aspects of the diverse linear chain substances have been summarized. 536 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains lectures and seminars presented at the Nato Advanced Study Institute on 'Laser Applications to Chemistry' held at San Miniato (Pisa) Italy, June 27 - July 11, 1982. We would like to give our recognition to all who contributed to the superb scientific quality and to the stimulating atmosphere of this summer school. In particular, we thank all speakers and participants in the discussions. We acknowledge the great efforts of Tito Arecchi as the director of the school, and the assistance of Mrs. Maria Bonaria Petrone and Mrs. Giovanna Ravini in the or ganization of the conference. On behalf of all participants we thank Miss Iva Arecchi for the friendly care she has taken and for her profound guidance through its history and the arts of the Toscana during the excursions. We are in particular indebted to Giacinto Scoles who organ ized this meeting together with Karl L. Kompa. Unfortunately, due to health reasons, Giacinto Scoles had to give up the idea of edit ing the proceedings of this meeting. Naturally, the change in the editorial staff caused a delay in the preparation of this volume. The subject of laser application to chemistry has not been review ed comprehensively in recent years. Many of the lectures andsem inars presented in San Miniato had the character of review arti cles. Therefore we feel that the material contained in this vol ume has not lost any of its actuality. 288 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume collects a number of the invited lectures and a few selected contrib utions presented at the International Symposium on Structure and Dynamics of Nucleic Acids, Proteins and Membranes held August 31st through September 5th, 1986, in Riva del Garda, Italy. The title of the conference as well as a number of the topics covered represent a continuation of two previous conferences, the first held in 1982 at the University of California in San Diego, and the second in 1984 in Rome at the Accademia dei Lincei. These two earlier conferences have been documented in Structure and Dynamics: Nucleic Acids and Proteins, edited by E. Clementi and R. H. Sarma, Adenine Press, New York, 1983, and Structure and Motion: Membranes, Nucleic Acids and Proteins, edited by E. Clementi, G. Corongiu, M. H. Sarma and R. H. Sarma, Adenine Press, New York, 1985. At this conference in Riva del Garda we were very hesitant to keep the name of the conference the same as the two previous ones. Indeed, a number of topics discussed in this conference were not included in the previous ones and even the emphasis of this gathering is only partly reflected in the conference title. An alternative title would have been Structure and Dynamics of Nucleic Acids, Proteins, and Higher Functions, or, possibly, 'higher components' rather than 'higher functions. 472 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Explosive developments in microelectronics, interest in nuclear metallurgy, and widespread applications in surface science have all produced many advances in the field of ion implantation. The research activity has become so intensive and so broad that the field has become divided into many specialized subfields. An Advanced Study Institute, covering the basic and common phenomena of aggregation, seems opportune for initiating interested scientists and engineers into these various active subfields since aggregation usually follows ion implantation. As a consequence, Drs. Perez, Coussement, Marest, Cachard and I submitted such a pro posal to the Scientific Affairs Division of NATO, the approval of which resulted in the present volume. For the physicist studying nuclear hyperfine interactions, the consequences of aggregation of implanted atoms, even at low doses, need to be taken into account if the results are to be correctly interpreted. For materials scientists and device engineers, under standing aggregation mechanisms and methods of control is clearly essential in the tailoring of the end products. 536 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume contains forty-six of the papers presented at the Ninth International Symposium on Acoustical Imaging held December 3-6, 1979, in Houston, Texas. The theme of the confer ence was the integration of applications technology. The major objective of the conference was to promote interaction among researchers working on different applications of acoustical imaging. In addition to serving as a state-of-the-art research ref erence, this volume includes six tutorial review papers. For convenience, all the papers are grouped under the following headings: methods, transducers, processing and display, phased array considerations, acoustic microscopy/non-destructive evalu ation, reconstructive tomography and inversion techniques, tissue characterization and impediography, nedica1 applications, under water applications, and seismic applications. The editor would like to thank the authors and the confer ence participants. The editor would also like to express his appreciation for the assistance in evaluating the abstracts from the following members of the Program Committee: Mahfuz Ahmed, University of California Irvine l:1edica1 Center; Pierre A1ais, Paris University, France; C. B. Burckhardt, Hoffman-Laroche, Basel, Switzerland; B. P. Hildebrand, Spectron Development Labora tories, Inc. , Costa Mesa, California; Larry W. Kessler, Sonoscan, Inc. , Bensenville, Illinois; Rolf Uue11er, University of Hinnesota, l1inneapo1is, Uinnesota; John P. Powers, Naval Post Graduate School, J:1onterey, California; Jerry L. Sutton, Naval Ocean Systems Center, San Diego, California; F. L. Thurstone, Duke University, Durham, North Carolina; Robert C. Waag, University of Rochester, Rochester, New York; and Glen Wade, University of California, Santa Barbara, California. 860 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -When the 1975 and 1976 symposia of The Marie Curie Memorial Foundation took place at the Royal College of Surgeons of England it was IDY great privilege to say a few words at the opening of each of them. It is equally a privilege to contribute these few introductory words to the Volume recording these symposia and I believe that it would not be inappropriate to recall with minor mod ifications some of the thoughts that occurred to me when I opened the symposium in 1976, for they do reflect the spirit of determined optimism, but without complacency, that characterized the contributions on both of these two occasions. In common with many others I always looked forward, from year to year, to the Meetings and admired each time the spirit which was so apparent and so very much in tune with the general philosophy of a surgeon, the spirit which admits that to a doctor and all others who care for patients cancer is a grim and terrible foe but suggests that, rather than sitting down and grizzling about it, we should bestir ourselves, do our best, whatever the difficulties, and at least try to do a little better each year. The title of the symposium in 1976 was typically stimulating,-'Towards a Solution',- not, admittedly a study of the solution itself but a title emphasising that the position was not static - that it was mobile, that we ~ moving forward and we do know where we are going. 332 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The presence of sophisticated auditory processing in mammals has permitted perhaps the most significant evolutionary development in humans: that of language. An understanding of the neural basis of hearing is thus a starting point for elucidating the mechanisms that are essential to human communication. The cochlear nucleus is the first region of the brain to receive input from the inner ear and is therefore the earliest stage in the central nervous system at which auditory signals are processed for distribution to higher centers. Clarifying its role in the central auditory pathway is crucial to our knowledge of how the brain deals with complex stimuli such as speech, and is also essential for understanding the central effects of peripheral sensorineural hearing loss caused by, for example, aging, ototoxic drugs, and noise. Ambitious new developments to assist people with total sensorineural deafness, including both cochlear and cochleus nuclear implants, require a detailed knowledge of the neural signals received by the brainstem and how these are processed. Recently, many new data have been obtained on the structure and function of the cochlear nucleus utilizing combinations of anatomical, physiological, pharmacological and molecular biological procedures. Approaches such as intracellular dye-filling of physiologically identified neurons, localization of classical neurotransmitters, peptides, receptors and special proteins, or gene expression have opened the door to novel morphofunctional correlations. 556 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -InhaltsangabeI. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- References.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- 1. Introduction.- 2. High-Mass Mass Spectrometry.- 3. Tandem Mass Spectrometry.- 3.1. Sequencing of Proteins.- 3.2. Increasing Sensitivity by Using an Array Detector.- 3.3. Computer-Aided Interpretation of CID Spectra of Peptides.- 4. Conclusion.- References.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 1. Goals.- 2. Folding of Fragments.- 3. Trapping Folding Intermediates.- References.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 1. Introduction.- 2. The Protein Folding Grammar.- 3. Intracellular Intermediates in Chain Folding and Assembly.- 4. Temperature-Sensitive Folding Mutations.- 5. Nonsense Mutations.- 6. Intracellular Aggregation and Inclusion Body Formation.- 7. Kinetics of Aggregate Formation.- 8. Isolation of Second-Site Suppressors of Folding Mutants.- 9. The Suppressing Amino Acid Substitutions Act at the Level of Polypeptide Chain Maturation.- 10. The Suppressors Act in the Folding of the Single Chain, Not during Chain-Chain Association.- 11. The Suppressors Increase the Efficiency of Folding of the Wild-Type Chain.- References.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- 1. Introduction.- 2. T4 Lysozyme.- 2.1. Sulfhydryl Oxidation.- 2.2. Thiol/Disulfide Interchange.- 2.3. Adsorption.- 2.4. Aggregation.- 2.5. Chemical Inactivation.- 2.6. Conclusions from T4 Lysozyme Experiments.- 3. Interferon- .- 3.1. In Vitro Experiments.- 3.2. Genetic Experiments.- 4. General Conclusions.- 4.1. Modes of Thermal-Irreversible Denaturation.- 4.2. Strategies for Stabilizing Proteins.- References.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- 1. Introduction.- 2. Isolation of Novel Protein-Tyrosine Kinases.- 3. Regulation of Protein-Tyrosine Kinase Activity: Phosphorylation of pp60c-src.- 4. Protein-Tyrosine Kinase Substrates.- References.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 1. The Family of G Proteins.- 2. Distribution of G Protein Subunits.- 3. Regulation of o Levels.- 4. G Proteins as Bifurcating Signals.- 5. Organizing Principles.- References.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 1. Introduction.- 2. Mechanisms of Receptor-Mediated Activation of G Proteins.- 3. Which G-Protein Subunit Mediates the Effect of Receptors .- 3.1. Regulation of Ionic Channels: or , and What Does Each Do to Regulation of Channel Activity .- 3.2. Inhibitory Regulation of Adenylyl Cyclase: i or .- 3.3. What Is the Role of Dimers .- References.- 9 Structural Homologies in G-Binding Proteins.- 1. Introduction.- 2. Structural Homology in Three Dimensions.- 2.1. Elongation Factor Tu (EF-Tu).- 2.2. ras Protein p21.- 3. Sequence Homology.- 3.1. Overall Homology.- 3.2. Consensus Sequences.- 4. Homology and Functional Similarity.- References.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 1. Introduction.- 2. Learning by Comparison of Structures.- 2.1. Superposition of Structures.- 2.2. Comparison of Properties and Relations.- 2.3. Clustering and Tree Construction.- 3. Rules for Tertiary Templates and Key Residues, and Their Comparison with a Sequence of an Unknown.- 3.1 Consensus Sequences for Framework Regions.- 3.2. Key Res.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the middle and late 1960s, when it was clear that neuroendocrinology was established as a discipline in its own right, it occurred to us that auto biographical accounts of the pioneer work in this field by the major par ticipants would provide a highly interesting and informative account of his tory in the making. With the death of G. W. Harris in late 1971, and the loss thereby of an outstanding pioneer and personality in neuroendocri nology, it appeared to us to be even more urgent to undertake such a ven ture and collect as many stories as possible. The three of us agreed that initially we would limit our invitations to the senior investigators whose re search careers lay mostly behind them, with the hope that if this venture proved successful, we could ask younger and still very active researchers in neuroendocrinology to contribute to a subsequent volume. Most of those invited to write for this book agreed to do so, but regrettably there remain some notable absentees. The authors were requested to write a personal, and even idiosyncratic, account of the steps taken, and the motivation and drive that led them to develop their interest in the relationship between the brain and the endocrine system. 340 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This fourth volume of Contemporary Topics In Immunobiology treats in vertebrate immunity. Specifically, the results represent several approaches to humoral and cellular immunity. It is evident that invertebrates do have function ing immune systems. For example, cellular immunity is characterized by both specificity and memory, but it is still problematical whether vertebrate immune capacity evolved directly from invertebrates. Most of the manuscripts were formally presented at the International Symposium on Invertebrate Pathology, University of Minnesota, August 1972, held in connection with the 25th anniversary celebration of the American Insti tute of Biological Sciences. I wish to express my appreciation to the contributors and to beg their indulgence in what may have been overzealous editing. This was done, though, in the interest of clarity and to seek uniformity. Because of earlier problems, time limitations did not permit consultations between submission of manuscripts and final editing. For assistance, I extend a special note of gratitude to Mrs. Lois Gehringer who unselfishly retyped many of the manuscripts. The preparation of this volume was aided partially by NSF Grant GB17767, two grants from The California Institute for Cancer Research, and a grant from The Brown-Hazen Corporation. E.L.C. Contents Introduction: General Comments and a Note on Taxonomy . . 320 pp. Englisch.