Items related to Protein Design and the Development of New Therapeutics...
Protein Design and the Development of New Therapeutics and Vaccines (New Horizons in Therapeutics) - Softcover
Synopsis
Based on a symposium held November 1988, in King of Prussia, Penn. Among the topics: structural analysis of proteins, protein folding and stability, receptor design and regulation, guanine nucleotide binding protein family, modeling and structure prediction in macromolecules, protein engineering and
"synopsis" may belong to another edition of this title.
Search results for Protein Design and the Development of New Therapeutics...
Stock Image
Protein Design and the Development of New Therapeutics and Vaccines (eng)
Print on DemandSeller: Brook Bookstore On Demand, Napoli, NA, Italy
Seller rating 5 out of 5 stars
Condition: new. Questo è un articolo print on demand. Seller Inventory # NRBRQIQUMI
Buy New
£ 40.46
£ 5.78 shipping
Ships from Italy to U.S.A.
Ships from Italy to U.S.A.
Quantity: Over 20 available
Seller Image
Protein Design and the Development of New Therapeutics and Vaccines
Published by
Springer US, Chapman And Hall/CRC Mär 2012, 2012
ISBN 10: 1468457411
ISBN 13: 9781468457414
New
Taschenbuch
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -InhaltsangabeI. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- References.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- 1. Introduction.- 2. High-Mass Mass Spectrometry.- 3. Tandem Mass Spectrometry.- 3.1. Sequencing of Proteins.- 3.2. Increasing Sensitivity by Using an Array Detector.- 3.3. Computer-Aided Interpretation of CID Spectra of Peptides.- 4. Conclusion.- References.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 1. Goals.- 2. Folding of Fragments.- 3. Trapping Folding Intermediates.- References.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 1. Introduction.- 2. The Protein Folding Grammar.- 3. Intracellular Intermediates in Chain Folding and Assembly.- 4. Temperature-Sensitive Folding Mutations.- 5. Nonsense Mutations.- 6. Intracellular Aggregation and Inclusion Body Formation.- 7. Kinetics of Aggregate Formation.- 8. Isolation of Second-Site Suppressors of Folding Mutants.- 9. The Suppressing Amino Acid Substitutions Act at the Level of Polypeptide Chain Maturation.- 10. The Suppressors Act in the Folding of the Single Chain, Not during Chain-Chain Association.- 11. The Suppressors Increase the Efficiency of Folding of the Wild-Type Chain.- References.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- 1. Introduction.- 2. T4 Lysozyme.- 2.1. Sulfhydryl Oxidation.- 2.2. Thiol/Disulfide Interchange.- 2.3. Adsorption.- 2.4. Aggregation.- 2.5. Chemical Inactivation.- 2.6. Conclusions from T4 Lysozyme Experiments.- 3. Interferon- .- 3.1. In Vitro Experiments.- 3.2. Genetic Experiments.- 4. General Conclusions.- 4.1. Modes of Thermal-Irreversible Denaturation.- 4.2. Strategies for Stabilizing Proteins.- References.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- 1. Introduction.- 2. Isolation of Novel Protein-Tyrosine Kinases.- 3. Regulation of Protein-Tyrosine Kinase Activity: Phosphorylation of pp60c-src.- 4. Protein-Tyrosine Kinase Substrates.- References.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 1. The Family of G Proteins.- 2. Distribution of G Protein Subunits.- 3. Regulation of o Levels.- 4. G Proteins as Bifurcating Signals.- 5. Organizing Principles.- References.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 1. Introduction.- 2. Mechanisms of Receptor-Mediated Activation of G Proteins.- 3. Which G-Protein Subunit Mediates the Effect of Receptors .- 3.1. Regulation of Ionic Channels: or , and What Does Each Do to Regulation of Channel Activity .- 3.2. Inhibitory Regulation of Adenylyl Cyclase: i or .- 3.3. What Is the Role of Dimers .- References.- 9 Structural Homologies in G-Binding Proteins.- 1. Introduction.- 2. Structural Homology in Three Dimensions.- 2.1. Elongation Factor Tu (EF-Tu).- 2.2. ras Protein p21.- 3. Sequence Homology.- 3.1. Overall Homology.- 3.2. Consensus Sequences.- 4. Homology and Functional Similarity.- References.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 1. Introduction.- 2. Learning by Comparison of Structures.- 2.1. Superposition of Structures.- 2.2. Comparison of Properties and Relations.- 2.3. Clustering and Tree Construction.- 3. Rules for Tertiary Templates and Key Residues, and Their Comparison with a Sequence of an Unknown.- 3.1 Consensus Sequences for Framework Regions.- 3.2. Key Res. Seller Inventory # 9781468457414
Stock Image
Protein Design and the Development of New Therapeutics and Vaccines (New Horizons in Therapeutics)
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
Condition: New. In English. Seller Inventory # ria9781468457414_new
Buy New
£ 55.95
£ 11.29 shipping
Ships from United Kingdom to U.S.A.
Ships from United Kingdom to U.S.A.
Quantity: Over 20 available
Seller Image
Protein Design and the Development of New Therapeutics and Vaccines
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 9 Structural Homologies in G-Binding Proteins.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 11 Computer Simulation Methods as Applied to Site-Specific Mutations.- 12 Dihydrofolate Reductase: A Paradigm for Drug Design.- VI. Protein Engineering and Enzyme Design.- 13 Chemical Approaches to Protein Engineering.- 14 New Engineered Proteins for Use in Therapy and Vaccine Design.- 15 Receptor-Based Design of Dihydrofolate Reductase Inhibitors.- VII. Macromolecules and Targeted Drug Delivery.- 16 Control of the Biological Dispersion of Therapeutic Proteins.- 17 Antibody-Mediated Drug Delivery.- 18 Semisynthetic Catalytic Antibodies.- VIII. Strategies for Directed Mutagenesis of Proteins.- 19 Engineering Novel, Prolonged-Acting Insulins.- IX. Design of Novel Antiviral Agents and Vaccines.- 20 Studies on the Structure andFunction of Ubiquitin.- 21 Recognition at Membrane Surfaces: Influenza HA and Human HLA. Seller Inventory # 9781468457414
Stock Image
Protein Design and the Development of New Therapeutics and Vaccines
Seller: Revaluation Books, Exeter, United Kingdom
Seller rating 5 out of 5 stars
Paperback. Condition: Brand New. reprint edition. 534 pages. 9.02x5.98x1.17 inches. In Stock. Seller Inventory # x-1468457411
Buy New
£ 69.63
£ 12.50 shipping
Ships from United Kingdom to U.S.A.
Ships from United Kingdom to U.S.A.
Quantity: 2 available
Seller Image
Protein Design and the Development of New Therapeutics and Vaccines
Print on DemandSeller: moluna, Greven, Germany
Seller rating 5 out of 5 stars
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- Reference. Seller Inventory # 4204297
Buy New
£ 42.34
£ 41.63 shipping
Ships from Germany to U.S.A.
Ships from Germany to U.S.A.
Quantity: Over 20 available
Seller Image
Protein Design and the Development of New Therapeutics and Vaccines
Published by
Springer, Springer Mär 2012, 2012
ISBN 10: 1468457411
ISBN 13: 9781468457414
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 9 Structural Homologies in G-Binding Proteins.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 11 Computer Simulation Methods as Applied to Site-Specific Mutations.- 12 Dihydrofolate Reductase: A Paradigm for Drug Design.- VI. Protein Engineering and Enzyme Design.- 13 Chemical Approaches to Protein Engineering.- 14 New Engineered Proteins for Use in Therapy and Vaccine Design.- 15 Receptor-Based Design of Dihydrofolate Reductase Inhibitors.- VII. Macromolecules and Targeted Drug Delivery.- 16 Control of the Biological Dispersion of Therapeutic Proteins.- 17 Antibody-Mediated Drug Delivery.- 18 Semisynthetic Catalytic Antibodies.- VIII. Strategies for Directed Mutagenesis of Proteins.- 19 Engineering Novel, Prolonged-Acting Insulins.- IX. Design of Novel Antiviral Agents and Vaccines.- 20 Studies on the Structure andFunction of Ubiquitin.- 21 Recognition at Membrane Surfaces: Influenza HA and Human HLA.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 516 pp. Englisch. Seller Inventory # 9781468457414
Stock Image
Protein Design and the Development of New Therapeutics and Vaccines (New Horizons in Therapeutics)
Seller: Mispah books, Redhill, SURRE, United Kingdom
Seller rating 4 out of 5 stars
Paperback. Condition: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book. Seller Inventory # ERICA77314684574116