springer us apr 2013 (662 results)

Taschenbuch. Condition: Neu. Neuware -Field-programmable logic has been available for a number of years. The role of Field-Programmable Logic Devices (FPLDs) has evolved from simply implementing the system `glue-logic' to the ability to implement very complex system functions, such as microprocessors and microcomputers. The speed with which these devices can be programmed makes them ideal for prototyping. Low production cost makes them competitive for small to medium volume productions. These devices make possible new sophisticated applications, and bring up new hardware/software trade-offs and diminish the traditional hardware/software demarcation line. Advanced design tools are being developed for automatic compilation of complex designs and routings to custom circuits. Digital Systems Design and Prototyping Using Field Programmable Logic covers the subjects of digital systems design and (FPLDs), combining them into an entity useful for designers in the areas of digital systems and rapid system prototyping. It is also useful for the growing community of engineers and researchers dealing with the exciting field of FPLDs, reconfigurable and programmable logic. The authors' goal is to bring these topics to students studying digital system design, computer design, and related subjects in order to show them how very complex circuits can be implemented at the desk. Digital Systems Design and Prototyping Using Field Programmable Logic makes a pioneering effort to present rapid prototyping and generation of computer systems using FPLDs. From the Foreword: `This is a ground-breaking book that bridges the gap between digital design theory and practice. It provides a unifying terminology for describing FPLD technology. In addition to introducing the technology it also describes the design methodology and tools required to harness this technology. It introduces two hardware description languages (e.g. AHDL and VHDL). Design is best learned by practice and the book supports this notion with abundant case studies.' Daniel P. Siewiorek, Carnegie Mellon University CD-ROM INCLUDED! Digital Systems Design and Prototyping Using Field Programmable Logic, First Edition includes a CD-ROM that contains Altera's MAX+PLUS II 7.21 Student Edition Programmable Logic Development Software. MAX+PLUS II is a fully integrated design environment that offers unmatched flexibility and performance. The intuitive graphical interface is complemented by complete and instantly accessible on-line documentation, which makes learning and using MAX+PLUS II quick and easy. The MAX+PLUS II version 7.21 Student Edition offers the following features: Operates on PCs running Windows 3.1, Windows 95 and Windows NT 3.51 and 4.0. Graphical and text-based design entry, including the Altera Hardware Description Language (AHDL) and VHDL. Design compilation for Product-term (MAX 7000S) and look-up table (FLEX 10K) device architectures. Design verification with full timing simulation. 368 pp. Englisch.

Taschenbuch. Condition: Neu. Neuware - The theme of this volume--risk analysis in the private sector--reflects a changing emphasis in risk analysis. Until re cently, attention has been focused on risk analyses conducted in support of federal regulatory decision making. Such analyses have been used to help set safety standards, to illuminate issues of regulatory concern, and to evaluate regulatory alternatives. As this volume indicates, however, risk analysis encompasses a broader set of activities. Analyses performed by private sector institutions aimed at preventing or reducing potential adverse health or environmental effects also play an important part in societal risk management. In virtually all societies, there have been strong incentives for the private sector to conduct such analyses. These incentives range from moral or altruistic norms and values to simple self-interest based on fear of monetary loss, possible civil or criminal litigation, or punitive or restrictive government action. The papers in this volume address the overall theme from a variety of perspectives. Specifically, the papers represent con tributions from such diverse fields as toxicology, epidemiology, chemistry, biology, engineering, statistics, decision analysis, economics, psychology, philosophy, and the law.

Taschenbuch. Condition: Neu. Neuware - Advances in Nutritional Research was conceived by the Public and Professional Information Committee of the American Institute of Nutrition as a service to the membership of the Institute and to others engaged in research and teaching in the nutritional sciences. This publication, which will consist of a series of annual volumes, is in tended to serve primarily as a source of authoritative information on the status of research on topics of active current investigation. In addition, it will contain reviews on subjects of research that have been characterized by progressive, if unspectacular, developments over a period of years. The coverage will extend to basic research in human, animal, and microbial nutrition, nutritional biochemis try, clinical nutrition, nutritional toxicology and pathology, and related specialties. The editors hope that this series will assist investigators to keep abreast of new developments in the broad field of nutritional research. It should be 'of particular value to graduate students and to investigators who wish to acquire a grasp of the current state of knowledge in fields other than their own. If the response of authors of the chapters in this first volume and the quality of their contributions are indicative, this hope will be realized. H. H. Draper Chairman, Board of Editors vii Contents Chapter 1 Role of Vitamin K in the Synthesis of Clotting Factors. . . 1 1. W. Suttie 1. Historical Background . .

Taschenbuch. Condition: Neu. Neuware - The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.

Taschenbuch. Condition: Neu. Neuware - This volume is the fourth in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de scription of depressive illness from a variety of perspectives that include that of the patient, the clinician, and the psychiatric researcher. It de scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysio logic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clini cally overlapping features such as anxiety disorders or eating disor ders. The effects on biology of comorbid conditions such as anxiety, personality disorders, alcoholism, and eating disorders are reviewed.

Taschenbuch. Condition: Neu. Neuware - Artificial Intelligence is entering the mainstream of com puter applications and as techniques are developed and integrated into a wide variety of areas they are beginning to tax the pro cessing power of conventional architectures. To meet this demand, specialized architectures providing support for the unique features of symbolic processing languages are emerging. The goal of the research presented here is to show that an archi tecture specialized for Prolog can achieve a ten-fold improve ment in performance over conventional, general-purpose architec tures. This book presents such an architecture for high perfor mance execution of Prolog programs. The architecture is based on the abstract machine descrip tion introduced by David H.D. Warren known as the Warren Abstract Machine (W AM). The execution model of the W AM is described and extended to provide a complete Instruction Set Architecture (lSA) for Prolog known as the PLM. This ISA is then realized in a microarchitecture and finally in a hardware design. The work described here represents one of the first efforts to implement the W AM model in hardware. The approach taken is that of direct implementation of the high level WAM instruction set in hardware resulting in a elSe style archi tecture.

Taschenbuch. Condition: Neu. Neuware - The emergence of a new scientific book series requires some explanation regarding how it hopes to compensate the reader for the discomforts it undoubtedly produces both in the realms of informational input-overload and in the financial strain on personal and institutional budgets. This series recognizes that investigators who have entered neurochemistry from the biochemical tradition have a rather specialized view of the brain. Too often, interdisciplinary offerings are initially attractive but turn out to recite basic biochemical considerations. We have come to believe that there are now sufficiently large numbers of neurochemists to support a specialized venture such as the present one. We have begun with consideration of traditional areas of neurochemistry which show considerable scientific activity. We hope they will serve the neurochemist both for general reading and for specialized information. The reader will also have the opportunity to reftect on the unbridled speculation that results from the disinhibiting effects on the author who has been invited to write a chapter. We plan occasionally also to offer reviews of areas not completely in the domain of neurochemistry which we nevertheless feel to be sufficiently timely to be called to the attention of all who use chemical principles and tools in an effort to better understand the brain. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 POSSIBLE ROLES OF PROSTAGLANDINS IN THE NERVOUS SYSTEM LEONHARD S. WOLFE 1. Introduction 1 1. 1. Background 1 Names and Structures 1. 2. 4 1. 3. Biosynthesis 4 1. 4.

Taschenbuch. Condition: Neu. Neuware - All around us, in this age of consumerism, are expressions of public expectations regarding the quality of medical care. Among the responses of the medical profession to this growing public demand has been a cre scendo of interest in continuing education. Continuing education is not a new concern for the physician. Most major professional organizations were founded to increase the exchange of information among members. But something new is in the wind. Both inside and outside the profes sion, the question is becoming more and more insistent: What does at tendance at meetings or exposure to other types of prepared materials have to do with the quality of care that is provided Recertification, reexamination, and peer review of outcomes of practice-subjects only recently unmentionable-have become common issues before specialty boards, legislatures, hospital boards, insurance carriers, and even medical societies. As of October of 1979, all 22 of the member boards of the American Board of Medical Specialties had made commitments to the principle of periodic recertification of their members. Most boards have explicitly acknowledged that the cognitive skills measured in the objective examination do not assure clinical competence. An assumption behind information-assessing recertification efforts is that, though mastery of the current knowledge upon which clinical decisions should be made does not guarantee competent practice, the lack of it probably impairs competent practice.

Taschenbuch. Condition: Neu. Neuware - The chapters of this book were prepared as task force reports under the aegis of the Biofeedback Society of America (BSA). The impetus for the present generation of task force reports can be dated back to 1982, when John D. Rugh, as President-Elect of the Society, announced that the updating of the task force reports would be given high priority during his term as President. An ad hoc Task Force Committee was appointed in 1983, and the committee set the following objectives: (1) solicit a widely based stream of input from all segments of the Biofeedback Society of America, (2) establish a peer review system to assure the highest degree of scholarship and an unbiased approach, (3) select for area authors only individuals who have profound knowledge of the area and who have demonstrated the ability to extend understanding by reviewing and criticizing the literature, (4) prepare all reports according to a standard ized format, and (5) publish all the reports simultaneously. Input came from several sources. Many people responded with ideas and suggestions to an announcement in the BSA Newsletter that the task force reports were being revised. In 1984, a symposium was conducted at the BSA annual meeting, which included round table dis cussions and dialogues between task force report authors and the BSA membership.

Taschenbuch. Condition: Neu. Neuware - As in any field of clinical or scientific endeavor, a cataloguing of the techniques and findings of behavioral pediatrics must follow shortly after the first few years of systematic work. This book has been designed to serve this initial summary function for the field. It represents a first attempt to bring together in one place the definition and scope of be havioral pediatrics and to outline current research and treatment ap proaches to various organic disorders, clinical settings, and problem areas in which a sufficient body of knowledge has accrued for author itative statement. As the first text in a rapidly expanding area, our decisions regarding the topics to be covered and the contributors to this volume were guided by our desire to represent what we would consider to exemplify the field in its early development: pragmatic and thorough study of signif icant problems from a base of sound scientific inquiry. Each of the topics addressed in the present volume develops, in a preliminary fashion, an epistemology for current practice and future study. All of the contrib uting authors have been involved in the development of their specialty areas through their research and, importantly, through their clinical work in the hospitals affiliated with the medical schools in which they hold appointments.

Taschenbuch. Condition: Neu. Neuware - The function of the vascular system is to transport oxygen and nutrients to the cells and to remove carbon dioxide and metabolites. It also transports hormones and locally produced neurohumoral substances which, in part, regulate its own function. These interrelationships are essential to homeostasis. The vascular system is not an assembly of simple (elastic) tubes but a dynamic system with many external and intrinsic regulatory mechanisms. The endothelium plays a major role in the intrinsic regulation of the system. The system is also often subject to disease processes of which atherosclerosis is the most important. As a result of atherosclerosis, and other disease processes, replacement of vessels with prosthetic devices may be required to reestablish adequate tissue blood flow. It is therefore imperative to gain insight into the details of vascular function, especially the dynamics, and the endothelium, the processes of atherosclerosis development, the vascular prosthetic possibilities and, last but not least, the interrelationships between these sub-specialties.

Taschenbuch. Condition: Neu. Neuware - 'Like a Bridge over Troubled Waters' The surge of current interest in the interface between clinical and social psychology is well illustrated by the publication of a number of general texts and journals in this area, and the growing emphasis in graduate programs on providing training in both disciplines. Although the bene fits of an integrated clinical-social approach have been recognized for a number of years, the recent work in this area has advanced from the oretical extrapolations of social psychological models to clinical issues to theory and research that is based on social principles and conducted in clinical domains. It is becoming increasingly common to find social psy chologists pursuing research with clinical populations and clinical psy chologists investigating variables that have traditionally been in the realm of social psychology. A major area of interface between the two disciplines is in research and theory concerned with how individuals respond to negative events. In addition to the trend toward an integrated clinical-social approach, the growing body of literature in this area reflects the explosion of cur rent interest in the area of health psychology; work by clinical and social psychologists on the topics of stress and coping has been one of the major facets of this burgeoning field. The purpose of the present volume is to provide a common forum for recent advances in the clinical and social literature on responses to negative life outcomes.

Taschenbuch. Condition: Neu. Neuware - The concept of a blood~retinal barrier is still relatively new in the ophthalmic literature. ~fuereas work on the blood-brain barrier was initiated in the first decade of this century, the blood retinal barrier has only recently been defined. Information accu mulated during the last 10 years has shown that the function of the blood-ocular barriers may be better understood if two main barrier systems are considered to exist in the eye. The blood-aqueous barrier regulates the exchanges between the blood and the intraocu lar fluids, and the blood-retinal barrier separates the neural tissue from the blood. Recent studies have shown that the blood-retinal barrier plays a fundamental role in controlling the microenvironment of the retina. Similarly, the significance of the blood-retinal barrier in retinal disease has become increasingly clear. Fluorescein angiography has demonstrated an intricate series of relationships between altera tions of the blood-retinal barrier and diverse retinal diseases, particularly vascular retinopathies and pigment epitheliopathies. Finally, in the past few years, vitreous fluorophotometry has pro vided a new and accurate index of the alteration of the blood-retinal barrier.

Taschenbuch. Condition: Neu. Neuware - This volume records the lectures given at a NATO Advanced Study Institute on Methods in Computational Molecular Physics held in Bad Windsheim, Germany, from 22nd July until 2nd. August, 1991. This NATO Advanced Study Institute sought to bridge the quite considerable gap which exist between the presentation of molecular electronic structure theory found in contemporary monographs such as, for example, McWeeny's Methods 0/ Molecular Quantum Mechanics (Academic Press, London, 1989) or Wilson's Electron correlation in moleeules (Clarendon Press, Oxford, 1984) and the realization of the sophisticated computational algorithms required for their practical application. It sought to underline the relation between the electronic structure problem and the study of nuc1ear motion. Software for performing molecular electronic structure calculations is now being applied in an increasingly wide range of fields in both the academic and the commercial sectors. Numerous applications are reported in areas as diverse as catalysis and interstellar chernistry, drug design and environmental studies, molecular biology and solid state physics. The range of applications continues to increase as scientists recognize the importance of molecular structure studies to their research activities. Recent years have seen a growing dependence of these applications on program packages, which are often not in the public domain and which may have a somewhat lirnited range of applicability dicta ted by the particular interests and prejudices of the program author.

Taschenbuch. Condition: Neu. Neuware - As we enter the last decade of the twentieth century, the AIDS epidemic looms ever larger and threatening. The specter of upwards of a million deaths in the United States and perhaps many millions worldwide from a sexually transmitted virus shakes our belief in modem medical science, while challenging the foundations of democratic society. Almost ten years into the epidemic, and with an enormous body of basic science research on the Human Immunodeficiency Virus (HIV), we still do not know why AIDS emerged when it did or how to stop its spread. A very humbling experience for scientists, clinicians, public health experts, politicians, and the general public. Yet there are signs that a well coordinated multidisciplinary research program can conquer the epidemic and, perhaps, provide the basis for preventing future epidemics. The HIV family of viruses is now better understood, both in terms of structure and function, than any other virus. Genetically engineered peptides and nucleic acids are being tested as specific treatments or vaccines against HIV infection/disease. Most prom ising are the strides which have been made in understanding those aspects of human behavior which have contributed to the spread of HIV infection and which must be substantially modified if AIDS is to be controlled and eventually eradicated. The basis of that understanding has roots in a diverse set of disciplines which have converged in the work presented in this book.

Taschenbuch. Condition: Neu. Neuware - H. J. BEYER AND H. KLEINPOPPEN During the preparation of Parts A and B of Progress in Atomic Spectros copy a few years ago, it soon became obvious that a comprehensive review and description of this field of modern atomic physics could not be achieved within the limitations of a two-volume book. While it was possible to include a large variety of spectroscopic methods, inevitably some fields had to be cut short or left out altogether. Other fields have developed so rapidly that they demand full cover in an additional volume. One of the major problems, already encountered during the prepar ation of the first volumes, was to keep track of new developments and approaches which result in spectroscopic data. We have to look far beyond the area of traditional atomic spectroscopy since methods of atomic and ion collision physics, nuclear physics, and even particle physics all make important contributions to our knowledge of the static and dynamical state of atoms and ions, and thereby greatly add to the continuing fascination of a field of research which has given us so much fundamental knowledge since the middle of the last century. In this volume, we have tried to strike a balance between contribu tions belonging to the more established fields of atomic structure and spectroscopy and those fields where atomic spectroscopy overlaps with other areas.

Taschenbuch. Condition: Neu. Neuware - No more than a fish loves water. - Is not this a strange fellow, my lord, that so confidently seems to undertake this business, which he knows is not to be done; damns himself to do, and dares better be damn'd than to dolt All's Well That Ends Well Act III, Sc. 6 This volume is the direct result of a NATO-Advanced Study Institute of the same title. held at Bishop's University, Lennoxville, Quebec, Canada, August 1974, under the joint sponsor ship of the NATO-Scientific Advisory Committee, National Research Council of Canada and the Universite de Montreal. It is not, however, strictly restricted to the lectures and seminars pre sented at the ASI. Contributions have been included from two workers who found at a fairly late stage that they could not attend and also included are a table giving the visual pigments and an other dealing with the distribution and development of retinomotor responses. I encouraged the authors to prepare speculative reviews highlighting their own research or that of their immediate col leagues and a number of them have done so. Several contributors, notably those who were asked to give lectures of a general nature at the ASI have written reviews of somewhat greater scope. The result is a collection of papers representing a great variety of approaches to the study of vision in fishes.

Taschenbuch. Condition: Neu. Neuware - After the appearance of the four-book series Human Nutrition: A Compre hensive Treatise, it became apparent to the editors that an important area of nutrition had been overlooked, namely, behavioral aspects of nutrition. There are two areas in which nutrition and behavior interact. On the one hand, mal nutrition may play a major role in determining behavior; alternatively, often aspects of behavior influence the eating habits of populations and individuals and thus affect their nutritional status. Volume 5 of this series speaks eloquently to both features of this important topic. Various aspects of the influence of behavior modification and nutrition have been explored by a number of qualified investigators. It is hoped that this volume will prove a valuable addition to the subjects covered in the other volumes. Roslyn B. Alfin-Slater David Kritchevsky Los Angeles and Philadelphia ix Contents Introduction: The Challenge of Nutrition and Environment as Determinants of Behavioral Development . . Janina R. Galler References . 5 Part I - Nutritional Deficiencies or Excesses Modifying Behavioral Outcome Chapter 1 Methological Requirements for Conceptually Valid Research Studies on the Behavioral Effects of Malnutrition David E. Barrett 1. Introduction . 9 2. Statistical-Conclusion Validity. . . . . . . . . . . . . . . . . . . . . 11 . . . . . . . 3. Internal Validity . 14 4. External Validity . 16 5. Construct Validity of Putative Causes and Effects . . . . . . . . . . . . 19 6. Conclusions and Recommendations . . . . . . . . . . . . . . . . . . . 28 . . . .

Taschenbuch. Condition: Neu. Neuware - In observing the development of modern scientific knowledge, many indivi duals have expressed concern over the rapid growth of information in various specialized disciplines. Over 100 years ago the first Secretary of the Smith sonian Institution, and more recently Dr. Vannevar Bush while proposing the modern expansion of the National Institutes of Health, both noted prob lems that prevented the proper utilization of information by individuals in medical and related scientific fields. These observations, tagether with con comitant implications of future difficulty, are particularly pertinent to the field of oncology. The rapid evolution of the latter discipline has largely been aided by the incorporation of concepts and methods developed over a long period of time, and drawn from a wide variety of other scientific fields. The large body of discoveries that have contributed to our current understanding of neoplasia, however, cannot be viewed as being made up of equal parts. They bring to mind Claude Bernard's view 'des determinismes simples et complexes' in the physiological and biochemical regulation of bod ily functions. He was able to observe that the most important and basic of physiologic processes were destined to be fewer in number than those of less fundamental and more highly specialized purpose. He understood that in the future development of medical science, sturlies of the lauer would occupy much of the time and attention of investigators, and were likely to contribute much to scientific literature.

Taschenbuch. Condition: Neu. Neuware - Enzymology of Alcohol and Aldehyde Dehydrogenases and Cytochrome P-450.- Role of Hydroxyl Radicals in Microsomal Oxidation of Alcohols.- On the Possible Relationship of Cytochrome P-450 to Alcohol Metabolism: Fundamental Aspects of the Microsomal Hydroxylation System, Including Properties and Interactions of the Components.- Evolution of Aldehyde Reductase: An Immunological Approach to the Relatedness of Aldehyde Reductase from Different Species.- Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity.- On the Interaction of Human Liver Aldehyde Dehydrogenase E1 Isoenzyme with Disulfiram and Iodoacetamide.- Ethanol-Inducible Liver Cytochrome P-450 in the Rat: Relative Specificity for Ethanol Oxidation Activity in Vitro.- Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse.- Isozymes of Alcohol Dehydrogenases.- Carbon-13 Magnetic Resonance Probe of Coenzyme and Inhibitor Binding in Liver Alcohol Dehydrogenase.- Properties of Adlehyde Dehydrogenase from Chemically-Induced Rat Hepatomas and Normal Rat Liver.- Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. II. Interactions of Cytochrome P-450 with Substrates and Nadph-Cytochrome % MathType!MTEF!2!1!+-% feaagCart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGabm4yayaaDa% aaaa!3700! $$underset{aise0.3emhbox{$smash{scriptscriptstyle-}$}}{c} $$ Reductase.- Alterations of Hepatic Alcohol Metabolizing Enzyme Activities Due to Thyroid Hormones.- Genetically Mediated Responses of Microsomal Ethanol Oxidation in Mice.- In Vivo Evaluation of Ambivalent Active-Site-Directed Inactivators of Liver Alcohol Dehydrogenase.- Kinetic and Mechanistic Studies of Oxidation of Vitamin a Alcohol to Vitamin a Aldehyde by Horse Liver Alcohol Dehydrogenase. The Inhibition by Ethanol and Pyrazole.- Mechanism of Inhibition of Mixed-Function Oxidation by Ethanol.- Multifunctionality of Liver Alcohol Dehydrogenase.- The Nature and Function of Aldehyde Reductases from Rat Brain.- Mechanism of the Magnesium Ion Activation of the Catalytic Activity of Horse Liver Aldehyde Dehydrogenase.- Kinetic Studies on NADPH-Linked Aldehyde Reductase from Human Liver.- Mitochondrial Energy Transducing Membrane and Minor Pathways of Alcohol Metabolism.- Structure of Cytochrome c Oxidase.- Acetaldehyde Directly Inhibits the Conversion of Androstenedione to Testosterone in the Testes.- Microsomal N-Depropargylation of Pargyline to Propiolaldehyde, an Irreversible Inhibitor of Mitochondrial Aldehyde Dehydrogenase.- The Presence of 2,3-Butanediol in the Blood of Chronic Alcoholics Admitted to an Alcohol Treatment Center.- Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption.- Relationships Between Bilayer Lipid, Motional Freedom of Oxidoreductase Components, and Electron Transfer in the Mitochondrial Inner Membrane.- A Possible Hemoglobin Marker of Alcoholism.- Distribution of Ethanol between Blood and Dorsal Subcutaneous Air of the Rat and the Feasibility of Using this Distribution Coefficient to Estimate Blood Ethanol.- Significance of the Gastrointestinal Tract in the in Vivo Metabolism of Ethanol in the Rat.- Lipid Peroxidation in Alcoholic Liver Disease in Man.- The Effect of Duration of Alcohol Administration on the Deposition of Trace Elements in the Fetal Rat.- The Role of Folates in Methanol Toxicity.- The ATP Synthesizing System of Liver Mitochondria.- The Temperature Dependence of Respiration and ATPase in Rat Liver Mitochondria is Altered by Ethanol.- Effect of Ethanol on Hemoperfusion and O2 Sufficiency in Livers in Vivo.- Ethanol as a Selective Inhibitor of Microsomal Barbiturate Hydroxylation in Vitro and in Vivo.- Direct Effect of Ethanol on Acid Secretion in Isolated Canine Gastric Mucosa.- Effects of Chronic Ethanol Consumption on the Respiratory Chain of Rat Liver Submitochondrial Particles.- Biochemical Compartmentation and Intermediary Metabolism.- Comparative Study of the Effect of Amino Acids on Ethanol Oxidation in Isolated Hepatocytes from Starved and Fed Rats.- Ethanol Oxidation in Isolated Hepatocytes.- Contributions of Cytosolic and Mitochondrial Acetyl-CoA Syntheses to the Activation of Lipogenic Acetate in Rat Liver.- Use of 13C NMR for Investigation of Ethanol Metabolism in Perfused Liver.- Changes in Liver Inorganic Pyrophosphate Content during Ethanol Metabolism.- Acetaldehyde and Acetate Production during Ethanol Metabolism in Perfused Rat Liver.- Breath Acetaldehyde Levels after Ethanol Consumption.- Determination of Hepatic Acetaldehyde and its Biphasic Relationship to the Ethanol Concentration in Rats.- Breath Acetaldehyde: Evidence of Acetaldehyde Production by Oropharynx Microflora and by Lung Microsomes.- The Effect of Chronic Ethanol Consumption on Pathways of Ethanol Metabolism.- Aldehyde Dehydrogenase Inhibitors and Voluntary Ethanol Drinking by Rats.- Rate-Determining Factors for Ethanol Metabolism in Vivo during Fasting.- Biochemical, Morphological and Clinical Correlates of Alcoholic Liver Disease.- Isolation of a Lipocyte-Rich Fraction from Rat Liver Nonparenchymal Cells.- Effects of Chronic Ethanol Feeding on Rat Hepatocytes.- The Effect of Ethanol on the Metabolism of Prostaglandins and Related Compounds.- Alcohol Dehydrogenase in Cultured Human Skin Fibroblasts Human Fibroblast Alcohol Dehydrogenase.- Kinetics and Control of Alcohol Oxidation in Rats.- Inhibition of the Synthesis of Macromolecules by Ethanol in Regenerating Rat Liver.- Psychotropic Drug Metabolism in Fetal Alcohol Syndrome.- Chronic Ethanol Ingestion and Glycogen Metabolism in Male and Female Rats.- Effects of Alcohol on -Glutamyl Transpeptidase (GGTP).- The Effect of Chronic Etha.

Taschenbuch. Condition: Neu. Neuware - The research reported in the third volume of Analytical Calorimetry covers a wide variety of topics. The variety indicates the sophistication which thermal analysis is reaching and addition ally the ever widening applications that are being developed, Advances in instrumentation include: microcalorimeter design, development and refinement of titration calorimetry, definition of further theory of scanning calorimetry, studies of the temperature of resolution of thermistors, and a refinement of the effluent gas analysis technique and its application to agricultural chemicals as well as organic materials. A wide variety of applications is reported. These cover the fields of polymeric materials, dental materials, inorganic proteins, biochemical materials, gels, mixed crystals, and other specialized areas. Contributions also include applications of important related techniques such as thermomechanical and thermogravimetric analysis. The contributions to this Volume represent papers presented before the Division of Analytical Chemistry at the Third Symposium on Analytical Chemistry held at the 167th National Meeting of the American Chemical Society, March 30 - April 5, 1974.

Taschenbuch. Condition: Neu. Neuware - Applications of Cryogenic Technology, Vol. 10, is the proceedings from the portion of the conference CRYO-90 sponsored by the Cryogenic Society of America (CSA). CRYO-90, held on the campus of the State University of New York, Binghamton, New York, was an unusual interdisciplinary event, drawing from the life sciences as well as the physical science and engineering areas of the low temperature community. Co-sponsoring CRYO-90 with CSA were the Society for Cryobiology and the Symposium on Invertebrate and Plant Cold Hardiness. These latter two organizations brought an exciting developing field to the conference, a field whose exploration will lead to the betterment of all mankind through improved cryosurgical and organ preservation techniques in addition to improved agricultural and herd yields under extreme conditions. Specific goals of the cryobiological community are cryopreservation, the arrest and recovery of living processes of cells, tissues and organs; and cryosurgery - the local cryodestruction of diseased cells while preserving the healthy surrounding tissue. These goals present great technological challenges. The technological requirements of the cryobiologist include the ability to cool tissues 6 at rates of 10 degrees per second (vitrification), to thaw frozen tissue without damaging the delicate cells, to freeze dry tissue using molecular distillation (vacuum) drying, to supercool cell structures below O°C without freezing, and to successfully store the preserved tissues and organs for any required length of time.

Taschenbuch. Condition: Neu. Neuware - The papers contained in this book were presented at a NATO Advanced Research Workshop (ARW) held at Cape Sounion, Athens, Greece, 19-24 May, 1991. The twenty-eight more comprehensive papers represent the key subjects of the ARW covered by invited speakers. The thirty-four short papers pre sented in a research format are contributions of those invited to participate in the ARW. There was a total of 70 participants from 21 countries. The objectives of the ARW were as follows: to review current knowledge of biological control of plant diseases and plant parasitic nematodes, with emphasis on mechanisms at the molecular, cellular, organismal, and ecosystem level; to examine and expand on current concepts and synthesize new concepts; to identify and prioritize limitations in the use of biological control for plant diseases and nematodes and the scientific research needed to overcome these limitations; and to develop strategies for biological control through management of resident agents or introduction of natural or modified agents.

Taschenbuch. Condition: Neu. Neuware - 1 The Lethal Osteochondrodysplasias.- 2 Mutations in Type I Procollagen Genes That Cause Osteogenesis Imperfecta.- 3 Structural Defects in Inherited and Giant Platelet Disorders.- 4 Genetic Aspects of Immunoglobulin A Deficiency.- 5 Oxidative Phosphorylation Diseases: Disorders of Two Genomes.- Addendum.

Taschenbuch. Condition: Neu. Neuware - The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.

Taschenbuch. Condition: Neu. Neuware - This volume is an up-to-date treatise of chemosensory vertebrate research performed by over 200 scientists from 22 countries. Importantly, data from over 25 taxa of vertebrates are presented, including those from human beings. Unlike other volumes on this topic, a significant nurober of the contributions come from leading workers in the former Soviet Union and reflect studies within a wide variety of disciplines, including behavior, biochemistry, ecology, endocrinology, genetics, psychophysics, and morphol ogy. Most of the studies described in this volume were presented at the Chemical Signals in Vertbrates VI (CSV VI) symposium held at the University of Pennsylvania in the summer of 1991. This international symposium was the largest and the most recent of a series of six such symposia, the first of which was held in Saratoga Springe, New York (June 6-9, 1976) and the last in Oxford, England (August 8-10, 1988). Unlike the previous symposia, Chemical Signals in Vertabrates VI lasted a full week, reflecting the increased number of participants and the desire of many to present their research findings orally to the group as a whole.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1 Biochemical Pharmacology of GABA in CNS.- 1. Introduction.- 2. Effects of Compounds on the Metabolism of GABA in Vivo.- 2.1. Systemic Administration.- 2.2. Intracranial and Topical Application.- 3. Effects of Compounds on the Uptake and Release of GABA in Nervous Tissue.- 3.1. Uptake Studies.- 3.2. Release Studies.- 4. Effects of Compounds on the Interaction of GABA with Its Postsynaptic Receptor.- 5. Convulsant and Anticonvulsant Compounds Related to the GABA-Dependent Inhibitory Mechanism.- 5.1. Mechanisms of Drug-Induced Convulsions.- 5.2. Mechanisms of the Anticonvulsant Action of Drugs.- 6. Pharmacological Relationships Between Biogenic Amines and GABA.- 7. Effects of Compounds on GABA Metabolism During Ontogeny.- 8. Pharmacological Effects of GABA.- 9. Clinical Implications of Pharmacological Studies of GABA-Dependent Inhibition.- 10. References.- 2 Biochemistry of Glycine, Taurine, Glutamate, and Aspartate.- 1. Introduction.- 2. Chemistry.- 3. Occurrence.- 3.1. Assay Methods.- 3.2. Regional Distribution.- 3.3. Subcellular Distribution.- 4. Metabolism.- 4.1. Glycine.- 4.2. Taurine.- 4.3. Glutamate and Aspartate.- 5. Transport.- 5.1. Uptake.- 5.2. Release.- 6. Conclusion.- 7. References.- 3 Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord.- 1. Introduction.- 2. Localization of Glycine and GABA in Spinal Cord.- 2.1. Localization in Gray and White Matter.- 2.2. Effect of Destruction of Interneurons.- 2.3. Cellular Localization from Uptake and Autoradiographic Studies.- 3. Release of GABA and Glycine.- 4. Pharmacology of Agonists.- 4.1. Effects on Reflex Activity.- 4.2. Postsynaptic Effects on Single Cells.- 4.3. Effects on Presynaptic Terminals.- 4.4. Effects on Dorsal Root Ganglia.- 5. Pharmacology of Antagonists.- 5.1. Strychnine.- 5.2. Bicuculline and Picrotoxin.- 6. Miscellaneous Agents.- 7. Amino Acids in Supraspinal Regions.- 7.1. Cuneate Nucleus.- 7.2. Reticular Formation.- 8. Concluding Remarks.- 9. References.- 4 Amino Acid Receptors in CNS. II. GABA in Supraspinal Regions.- 1. Introduction.- 2. Inhibitory Action of GABA on Cortical Neurons.- 2.1. Extracellular Recording.- 2.2. Intracellular Recording.- 2.3. Antagonism.- 3. GABA Receptors in Supraspinal Regions Other Than Cerebral Cortex.- 3.1. Cuneate Nucleus.- 3.2. Deitersż Nucleus.- 3.3. Cerebellar Cortex.- 3.4. Striatonigral Pathway.- 3.5. Olfactory Bulb.- 4. Inhibitory Interneurons of Cerebral Cortex.- 5. Structure-Activity Relationships.- 5.1. GABA-like Amino Acid.- 5.2. GABA Antagonists.- 5.3. Picrotoxin.- 5.4. Bicuculline.- 5.5. Conclusion.- 6. References.- 5 Excitatory Amino Acid Receptors in the Central Nervous System.- 1. Introduction.- 2. Mechanisms of Glutamate Action.- 3. Excitation of Neurons by Analogues and Homologues of Glutamate.- 4. Receptors for Glutamate Uptake.- 5. Antagonists of Amino Acid-Induced Excitations.- 6. Antagonists of Glutamate Uptake.- 7. The Amino Acids as Physiological Synaptic Transmitters.- 8. References.- 6 Peptide Receptors in CNS.- 1. Introduction.- 2. Angiotensin II.- 2.1. Characterization and Localization of Central Effects.- 2.2. Structural Requirements for Activity.- 2.3. Mechanism of Action.- 2.4. Access of Angiotensin to Central Sites and Its Presence in Brain.- 3. Substance P and Related Peptides.- 3.1. Distribution and Release.- 3.2. Pharmacology.- 4. Neurohypophyseal Hormones.- 4.1. Synaptic Properties of Neurosecretory Cells.- 4.2. Action of Neurohypophyseal Hormones in CNS.- 5. Other Peptides.- 5.1. Bradykinin.- 5.2. Adenohypophyseal Hormones and Hypothalamic Releasing Factors.- 5.3. Sleep Factor Delta.- 6. Conclusion.- 7. References.- 7 Amine and Amino Acid Receptors in Gastropod Neurons.- 1. Introduction.- 2. Electrophysiological Results from a Multireceptor System and Their Relationship to Methodology.- 2.1. General Findings Concerning ACh Responses in Aplysia Neurons.- 2.2. Relationship of These General Findings to Methodology.- 3. Rżmżf Receptor Pharmacology for Amines and Amino Acids.- 3.1. ACh Receptors.- 3.2. Serotonin Receptors.- 3.3. Dopamine Receptors.- 3.4. GlutamicAcid.- 3.5. Other Receptors.- 4. Analysis of Certain Drug-Receptor Characteristics in Molluscs.- 4.1. Action Spectrum of Antagonists.- 4.2. Slow Responses.- 4.3. Dose-Response Curves from Molluscan Neurons.- 4.4. Receptor Localization.- 5. Conclusions.- 6. References. 332 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The principal results of the work are as follows: 1. A simplified technique was devised for obtaining Raman spectra of powders. 2. The Raman and infrared absorption spectra of the following oxides were investigated: AsP3' SbP3' As 0 SbP5. Te02. Ge02 (two forms) in the crystalline state, and ASP3' Ge02' Te0 in the glassy state. 2 5 2 3. The vibrational spectra of the crystalline and glassy forms of the oxides ASP3' Ge02' Te02 are simi lar in many main respects, indicating a similarity of their structural units which determine the vibrational spec tra of these substances. 4. By a study of the vibrational spectrum it was shown that arsenious anhydride has a molecular structure and consists of As0 molecules having symmetry of the point group Td' The force constants and vibration fre 4 6 quencies of the As 0 molecule were calculated. and the vibrational spectrum of arsenious anhydride was re 4 6 liably interpreted with the aid of these results. 5. A similar result was obtained for antimonous anhydride. consisting of Sb0 molecule.s with symmetry 4 6 ofthe point group Td. The force constants for this molecule were found and the vibrational spectrum was calculated. 196 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Second International Conference on Phonon Scattering in Solids was held at the University of Nottingham from August 27th - 30th 1975. It was attended by 192 delegates from 24 countries who were accompanied by 43 members of their families. Eleven invited papers were read and 96 contributed papers; the contributed papers were in two parallel sessions. The Conference included the topics of the two International Conferences held in France in 1972, in Paris and at Ste Maxime. The Conference brought together workers concerned with many aspects of phonon scattering in solids and liquid helium. Some of the work reported were studies of the intrinsic properties of diel ectric materials such as the effects of anharmonicity, dispersion and anisotropy on phonon propagation and the conditions for the existence of zero sound and second sound modes. Work was also pres ented on various aspects of phonon interaction with free electrons in metals and semiconductors. A substantial part of the Conference was devoted to phonon spectroscopy - investigations of the energy levels of ions or neutral impurities by observing the resonant absorp tion or scattering of phonons. The materials being studied include paramagnetic and parae1ectric solids, amorphous systems in which the 'impurities' appear to be intrinsic, and semiconductors. Work was reported on the use of phonons to observe phase transitions; in some cases the cooperative phase also arises through strong spin phonon coupling. One of the intriguing unsolved problems discussed in detail at the Conference is the Kapitza conductance problem. 464 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Opportunistic, intracellular bacterial infections are in the forefront of research today because of the challenges they present to the immunocompromised patient. In this volume, the pathogenesis and immune reaction of these intracellular infections is featured, as are the most typical problems related to antimicrobial chemotherapy, and current approaches to their solution. Notable chapters set the pace for research on the pathogenic and immune reactions to such infections as Mycobacterium tuberculosis Legionella pneumophila Chlamydia trachomatis and Brucella . 332 pp. Englisch.