Cold Spring Press (Over 3,900 results)

Hardback. Condition: Very Good. Advances in medicine have made possible better treatments for widespread, familiar human illnesses like cancer, diabetes, and heart disease. Yet there are thousands of much less common diseases, most of genetic origin, each classed as rare because it afflicts only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an effective remedy. Yet these orphaned diseases collectively caused misery and expense, often far greater than did more common ailments, for tens of millions of individuals and their families. Forty years ago, a revolution that transformed the prospects of patients with rare diseases was lit by three sparks. The passage of the 1983 U.S. Orphan Drug Act resulted from public pressure brought by rare disease patients, their families, and advocates. The AIDS epidemic triggered additional activism, compounded when patients with the rare disease hemophilia became HIV-positive after infusion of tainted blood products. And the third spark was the emergence in the early 1980s of biotechnology companies like Genentech, Amgen, and Biogen employing then-new genetic engineering instead of conventional approaches to pharmaceutical development. Soon after, Genzyme became the first company to develop a treatment for a rare genetic disorder, Gaucher disease, which would come to transform the industry. Jim Geraghty has been a passionate participant in the orphan drug revolution since its inception--a leader in the field as a strategy consultant, biotechnology executive, and venture entrepreneur. His book is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen. And it tells deeply personal stories of patients and parents willing to risk new, untried therapies. But Geraghty also uses his exceptional experience and vantage point to look forward to the immense promise of the newest technologies like gene therapy and gene editing for the treatment of patients today and tomorrow. He concludes with thoughtful consideration of important questions. Why do drugs to treat orphan diseases cost so much? How can we ensure they are affordable? How can their effectiveness be responsibly assessed? And how can access to them be expanded internationally? This book graphically and poignantly illustrates how far an important healthcare revolution has come and reminds us that if not nurtured, it could end before its immense promise has been fulfilled.…

Condition: Good. Good condition ex-library book with usual library markings and stickers.

Condition: Acceptable. Item in acceptable condition! Textbooks may not include supplemental items i.e. CDs, access codes etc.

Paperback. Condition: Good. HR Director and Get a Job author Dan Quillen shows readers how to craft an incredible resume that will get job-seekers in the door This is the follow-on book to the author's Get a Job book (Fall 2013), and is the first in a series of books written by Dan Quillen. Once again, Quillen calls on his expertise as an HR professional (and as one who lost and found a job in the toughest economic environment since the Great Depression) to help his readers understand the New Economy, and how to find work when many cannot. The Perfect Resume focuses on that most important tool in the job hunter's quiver -- the resume. Quillen walks his readers through the technical aspects of resume writing, but also helps them understand the tricks of the resume-writing trade. He teaches readers how to write resumes that end up in the hands of hiring managers, not screened by gatekeepers and deposited in the recycle bin. Topics covered: - The current economic environment - You lost your job -- what do you do now? - The importance of a resume - The mechanics of resume writing - Three types of resumes and their uses (Chronological, Functional, Combination) - One size doesn't fit all (Targeting your resume) - Your resume template - How to handle resume difficulties (Gaps in employment, Short-term employment, Lack of experience) - Section-by-section resume reviews.…

Condition: Good. Item in good condition. Textbooks may not include supplemental items i.e. CDs, access codes etc.

Condition: very_good. Book is in very good condition and may include minimal underlining highlighting. The book can also include "From the library of" labels. May not contain miscellaneous items toys, dvds, etc. . We offer 100% money back guarantee and 24 7 customer service.

Condition: good. Book is in good condition and may include underlining highlighting and minimal wear. The book can also include "From the library of" labels. May not contain miscellaneous items toys, dvds, etc. . We offer 100% money back guarantee and 24 7 customer service.

Paperback. Condition: Good.

Paperback. Condition: Good. Based on unproduced episodes of Star Wars: The Clone Wars, this new novel features Asajj Ventress, former Sith apprentice turned bounty hunter and one of the great antiheroes in theStar Wars galaxy. The only way to bring down the Sith s most dangerous warrior may be to join forces with the dark side. In the war for control of the galaxy between the armies of the dark side and the Republic, former Jedi Master turned ruthless Sith Lord Count Dooku has grown ever more brutal in his tactics. Despite the powers of the Jedi and the military prowess of their clone army, the sheer number of fatalities is taking a terrible toll. And when Dooku orders the massacre of a flotilla of helpless refugees, the Jedi Council feels it has no choice but to take drastic action: targeting the man responsible for so many war atrocities, Count Dooku himself. But the ever-elusive Dooku is dangerous prey for even the most skilled hunter. So the Council makes the bold decision to bring both sides of the Force s power to bear pairing brash Jedi Knight Quinlan Vos with infamous one-time Sith acolyte Asajj Ventress. Though Jedi distrust for the cunning killer who once served at Dooku s side still runs deep, Ventress s hatred for her former master runs deeper. She s more than willing to lend her copious talents as a bounty hunter and assassin to Vos s quest. Together, Ventress and Vos are the best hope for eliminating Dooku as long as the emerging feelings between them don t compromise their mission. But Ventress is determined to have her retribution and at last let go of her dark Sith past. Balancing the complicated emotions she feels for Vos with the fury of her warrior s spirit, she resolves to claim victory on all fronts a vow that will be mercilessly tested by her deadly enemy . . . and her own doubt. Praise for Dark Disciple Reading Dark Disciple really feels like you re watching some of the best episodes of The Clone Wars. EUCantina Emotionally charged. . . Christie Golden does a wonderful job of capturing the characters. Roqoo Depot A cool inclusion into the Star Wars mythos . . . Ventress and Vos have a cool and compelling dynamic, and are used to explore more of what it means to flirt with the Dark Side of the Force. IGN The Clone Wars have been] a huge part of the Star Wars brand for years, and Christie] Golden manages to craft a story worthy of the themes and characters that fans have come to relate to. . . . She] uses this opportunity to craft Dark Disciple into a spy/espionage thriller. Tech Times Golden especially excelled at bringing Ventress s biting but appealing personality to life. . . . She s very much a woman trying to find her way, and Dark Disciple adds nuance. Nerdist Smart, captivating, and unforgettable . . . among the finest in Star Wars storytelling. Coffee with Kenobi From the Hardcover edition.…

Paperback. Condition: Very Good. Original. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible, with all pages included. It may have slight markings and/or highlighting.

Condition: good. Fast Free Shipping â" Good condition. It may show normal signs of use, such as light writing, highlighting, or library markings, but all pages are intact and the book is fully readable. A solid, complete copy that's ready to enjoy.

Paperback. Condition: Good.

Hardback. Condition: Good. Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Paperback. Condition: Good. Histoire de la litt rature fran aise l' tranger, depuis le commencement du XVIIe si cle, by Pierre Andr Sayous, explores the reception and influence of French literature abroad from the 17th century onwards. This historical study delves into the dissemination of French literary works and ideas across various countries, examining their impact on foreign cultures and literary traditions. Sayous provides a detailed account of the critical reception, translation, and adaptation of French literary masterpieces in different linguistic and cultural contexts. This work offers valuable insights into the international dimensions of French literature and its enduring legacy. It remains an important resource for scholars and readers interested in the history of literary exchange and the global reach of French literary culture.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.…

Condition: good. Book is in good condition and may include underlining highlighting and minimal wear. The book can also include "From the library of" labels. May not contain miscellaneous items toys, dvds, etc. . We offer 100% money back guarantee and 24 7 customer service.

Hardback. Condition: Fair. Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you can read about for the first time in this book, along with compelling stories about the physicians, scientists, and parents who have taken them on. The diseases include phenylketonuria, sickle cell anemia, dystrophic epidermolysis bullosa, X-linked hypohidrotic ectodermal dysplasia, and Friedreich's ataxia-just a few of the more than 1000 genetic disorders that are well-described and many more that are not. Many manifest in infancy. Some show up in mid-childhood, others later in childhood, and still others among adults. They touch almost every extended family. Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us.…

paperback. Condition: Good.

Paperback. Condition: Fair. The item might be beaten up but readable. May contain markings or highlighting, as well as stains, bent corners, or any other major defect, but the text is not obscured in any way.

paperback. Condition: Fair.

Paperback. Condition: Very Good. Third Edition. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible, with all pages included. It may have slight markings and/or highlighting.

Paperback. Condition: Good.

paperback. Condition: Very Good.

paperback. Condition: Good.

Condition: good. Fast Free Shipping â" Good condition. It may show normal signs of use, such as light writing, highlighting, or library markings, but all pages are intact and the book is fully readable. A solid, complete copy that's ready to enjoy.

Paperback. Condition: Fair. Illustrated. The item might be beaten up but readable. May contain markings or highlighting, as well as stains, bent corners, or any other major defect, but the text is not obscured in any way.

Condition: acceptable. This copy has clearly been enjoyedâ"expect noticeable shelf wear and some minor creases to the cover. Binding is strong, and all pages are legible. May contain previous library markings or stamps.

Condition: very_good. Fast Free Shipping â" Very Good condition book with a firm cover and clean pages. Shows normal use and some light wear or limited notes markings. A solid, nice copy to enjoy.

Paperback. Condition: Very Good. 1. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible, with all pages included. It may have slight markings and/or highlighting.

Paperback. Condition: Very Good. 1. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible, with all pages included. It may have slight markings and/or highlighting.

hardcover. Condition: Good.