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Language: English
Published by John Wiley & Sons Inc, New York, 2008
ISBN 10: 0470518235 ISBN 13: 9780470518236
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Hardcover. Condition: new. Hardcover. Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomicsanalysis and interpretation of toxicogenomic dataprinciples of data mining in toxicogenomicsdesign issues in toxicogenomics studiessources of variability in toxicogenomic assaysEscherichia coli stress response as a tool for detection of toxicitytoxicogenomics as a tool to assess immunotoxicitytoxicogenomics and ecogenomics for studying endocrine disruption and basic biologyuse of toxicogenomics as an early predictive tool for hepatotoxicitynutrigenomics: the application of genomic signatures in nutrition-related researchapplication of toxicogenomics in drug discoverypotential uses of toxicogenomic biomarkers in occupational health and risk assessmentusefulness of toxicogenomics in the regulatory environmentperspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products. Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Language: English
Published by John Wiley & Sons Inc, New York, 2013
ISBN 10: 1118401611 ISBN 13: 9781118401613
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Hardcover. Condition: new. Hardcover. During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. Divided into six parts, topics covered include: microRNA and toxicology including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancermicroRNAs and disease statesmicroRNAs and stem cellsmicroRNAs and genomicsmicroRNAs and epigenomicsmicroRNAs and biomarkers including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitis microRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government. Providing insight into the trends and future directions of research in this rapidly developing new field, this book offers a comprehensive and authoritative compilation of developments in the role of Micrornas in disease and their use in toxicology. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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