Pals S T (1 results)
P53 and CD44 as Markers of Tumor Progression in Colorectal Carcinogenesis
Mulder, Jan-Willem Rudolf; Wielenga, V. J. M.; Pals, S. T.; Offerhaus, G. J. A.
Published by Universiteit van Amsterdam, Amsterdam, The Netherlands
- Softcover
- First Edition
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Softcover. Condition: Very Good. No Jacket. First Edition. Very Good+ condition. The covers look great. There is a small stain on the bottom edge of the text block. The binding is tight. The interior pages are clean and unmarked. There is a small abrasion to the front flyleaf. No dust jacket, possibly as issued. USPS electronic…tracking number issued free of charge. Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppress or gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly. Academic Medical Centre, University of Amsterdam, Department of Pathology, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. J. W. R. Mulder, V. J. M. Wielenga, S. T. Pals & G. J. A. Offerhaus.
