Kooy Frank (18 results)

Softcover. Condition: Fine. First Edition. stapled format, 60 pages. light shelf wear and usage markings. excellent binding. [SK]. Our orders are shipped using tracked courier delivery services.

Condition: New. pp. 132.

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Hardcover. Condition: Brand New. 498 pages. 9.25x7.50x1.25 inches. In Stock.

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Condition: New. Wasser in der StadtStinkende Abwaesser im staedtischen Untergrund oder kristallklares Wasser im heimischen Bad - eine funktionierende Abwasserentsorgung ist in der modernen Stadt ebenso unabdingbar wie eine gute Wasserversorgung. Die Nutzung des Wassers s.

Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: van der Kooy FrankFrank van der Kooy was born in 1975 in Pretoria, South Africa. Henstudied at the University of Pretoria and completed his PhD atnthe Department of Plant Sciences. His research focussed on thendevelopment of naphthoq.

Condition: New. Print on Demand pp. 132 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

Condition: New. PRINT ON DEMAND pp. 132.

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The antimycobacterial activity of severalnaphthoquinones initiated this study into theoccurrence, chemistry and biological activity ofthese compounds. This book deals with the traditionaluse of plants to treat TB-like symptoms and attemptsto establish a link between naphthoquinones and theseplants with the use of a metabolomics approach. Itfurthermore deals with the chemical synthesis of themain lead compound and some derivatives. This isfollowed by the often neglected stability studiesperformed on the main active compounds. These studiesshowed that rapid breakdown of lead compounds dooccur during activity and toxicity testing, and thatthis leads to false positives and negatives. Theactivity and toxicity of the main active compoundswere tested using three models: Vero cells, mice andMusca domestica. The last chapters deal with theinvestigation of a structure activity relationshipand propose a mechanism of action for thesenaphthoquinones. It was found that this class ofcompounds interfere with the electron transport chainby inhibiting menaquinone to bind to the cytochromecomplex. This indicates that these compounds mightbecome a new class of antibiotics.

Condition: new. Questo è un articolo print on demand.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. 'This fascinating book, edited by Rob Willemsen and Frank Kooy, summarizes the current knowledge of the molecular aspects of fragile X syndrome (FXS), andthe potential for therapies resulting from this knowledge.Particularly interesting is a review 'fragile X research from a parental perspective,? which summarizes the results of an international survey of the attitudes of families with FXS relatives towards research.This book is also an essential reference book for genetic counselors.The book provides counselors with the necessary biological background for proper explanations to the relatives of FXS patients. Many parents acquire a substantial knowledge of the conditions afflicting their children. The book will be helpful for both families and counselors to manage the expectations of families participating in clinical trials.In conclusion, this book is essential for everyone who is involved in the diagnosis and treatment of FXS patients.? - European Journal of Human Genetics (September 2018) 498 pp. Englisch.

Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. 'This fascinating book, edited by Rob Willemsen and Frank Kooy, summarizes the current knowledge of the molecular aspects of fragile X syndrome (FXS), andthe potential for therapies resulting from this knowledge.Particularly interesting is a review 'fragile X research from a parental perspective,? which summarizes the results of an international survey of the attitudes of families with FXS relatives towards research.This book is also an essential reference book for genetic counselors.The book provides counselors with the necessary biological background for proper explanations to the relatives of FXS patients. Many parents acquire a substantial knowledge of the conditions afflicting their children. The book will be helpful for both families and counselors to manage the expectations of families participating in clinical trials.In conclusion, this book is essential for everyone who is involved in the diagnosis and treatment of FXS patients.? - European Journal of Human Genetics (September 2018).