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The Histone Code and Beyond: New Approaches to Cancer Therapy (Ernst Schering Foundation Symposium Proceedings)
Seller: The Book Exchange, Macclesfield, CHESH, United Kingdom
Seller rating 5 out of 5 stars
Hardcover. Condition: Very Good. 3540278575. Ernst Schering Research Foundation Workshop 57. Hardcover, from closed pharmaceutical company library. Lending record shows this book has never been borrowed. 232 pages, index, illustrated in colour with charts, tables and diagrams. Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. Contents clean, tight and bright. Book.
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Cancer Stem Cells. Novel Concepts and Prospects for Tumor Therapy. Edited by O.D. Wiestler, B. Haendler and D. Mumberg. (Ernst Schering Foundation Symposium Proceedings 2006-5).
Language: English
Published by Berlin, Heidelberg & New York: Springer, 2007
ISBN 10: 3540708529 ISBN 13: 9783540708520
Seller: Antiquariat Kretzer, Kirchhain-Emsdorf, Germany
Association Member: GIAQ ILAB VDA
Seller rating 5 out of 5 stars
Condition: Wie neu. XVI, 263 Seiten. Mit 42 Abbildungen. Tadellos erhaltenes Exemplar. / As new. ISBN: 9783540708520 Sprache: Englisch Gewicht in Gramm: 990 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden].
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The Ubiquitin System in Health and Disease. Edited by S. Jentsch and B. Haendler. (Ernst Schering Foundation Symposium Proceedings 2008-1).
Language: English
Published by Berlin, Heidelberg & New York: Springer, 2009
ISBN 10: 3540851062 ISBN 13: 9783540851066
Seller: Antiquariat Kretzer, Kirchhain-Emsdorf, Germany
Association Member: GIAQ ILAB VDA
Seller rating 5 out of 5 stars
Condition: Wie neu. XV, 190 Seiten. Mit 39 Abbildungen. Neuwertiges Exemplar. / As new. ISBN: 9783540851066 Sprache: Englisch Gewicht in Gramm: 990 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden].
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The Histone Code and Beyond. New Approaches to Cancer Therapy. Edited by S.L. Berger, O. Nakanishi and B. Haendler. (= Ernst Schering Research Foundation Workshop, Band 57).
Language: English
Published by Berlin, Heidelberg, Tokyo u.a.: Springer, 2006
ISBN 10: 3540278575 ISBN 13: 9783540278573
Seller: Antiquariat Kretzer, Kirchhain-Emsdorf, Germany
Association Member: GIAQ ILAB VDA
Seller rating 5 out of 5 stars
Condition: Wie neu. XIV, 209 Seiten. Mit 36 Abbildungen. Tadellos erhaltenes Exemplar. / As new. ISBN: 9783540278573 Sprache: Englisch Gewicht in Gramm: 990 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden].
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
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Condition: New. pp. 284.
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Condition: New. pp. 284.
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Condition: Used. pp. 232.
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Condition: Used. pp. 232 Illus.
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Condition: New. pp. 284.
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
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Condition: Used. pp. 232.
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
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Hardcover 15*22. Condition: Gut. 209 Seiten altersbedingt sehr guter Zustand Herausgeber: Schering 200419743 Sprache: Englisch Gewicht in Gramm: 400.
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The Histone Code and Beyond: New Approaches to Cancer Therapy (Ernst Schering Foundation Symposium Proceedings, 57)
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 96.88
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Ships from United Kingdom to U.S.A.Quantity: Over 20 available
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The Histone Code and Beyond: New Approaches to Cancer Therapy (Ernst Schering Foundation Symposium Proceedings, 57)
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 96.88
£ 11.98 shipping
Ships from United Kingdom to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. In.
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Condition: New.
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Condition: New.
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Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating proteinżprotein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?-amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals.
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Condition: New.
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The Ubiquitin System in Health and Disease (Ernst Schering Foundation Symposium Proceedings, 2008/1)
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 121.47
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Ships from United Kingdom to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. In.
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Condition: New.
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Hardcover. Condition: Brand New. 1st edition. 209 pages. 8.75x6.00x0.50 inches. In Stock.
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Taschenbuch. Condition: Neu. The Histone Code and Beyond | New Approaches to Cancer Therapy | Shelley L. Berger (u. a.) | Taschenbuch | Ernst Schering Foundation Symposium Proceedings | xiv | Englisch | 2014 | Springer | EAN 9783642421754 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
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The Histone Code and Beyond : New Approaches to Cancer Therapy
Language: English
Published by Springer, J.B. Metzler, 2006
ISBN 10: 3540278575 ISBN 13: 9783540278573
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
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The Ubiquitin System in Health and Disease (Ernst Schering Foundation Symposium Proceedings, 2008/1)
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 137.84
£ 11.98 shipping
Ships from United Kingdom to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. In.
