Bohr V a (10 results)

Hardcover. Condition: New.

Condition: New.

Condition: As New. Unread book in perfect condition.

Condition: New.

Condition: As New. Unread book in perfect condition.

Gebunden. Condition: New. Aging occurs at the level of individual cells, a complex interplay between intrinsic programming and exogenous wear and tear , with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate o.

Hardcover. Condition: Very Good. Dust Jacket Condition: Good. 1st Edition. VERY GOOD/GOOD; FIRST EDITION; papers in ENGLISH, GERMAN AND FRENCH; the pages are clean and unmarked and the binding is very good; the dust jacket has edgewear, chipping, rubbing and small tears and sunning to the spine yet remains in good condition; there are no signatures or book plates present; 4to - over 9¾" - 12" tall Size: 4to - over 9¾" - 12" tall.

Hardcover. Condition: Brand New. 1st edition. 257 pages. 9.40x6.70x0.80 inches. In Stock. This item is printed on demand.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aging occurs at the level of individual cells, a complex interplay between intrinsic 'programming' and exogenous 'wear and tear', with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, 'The Role of DNA Damage and Repair in Cell Aging' provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.As part of a series entitled 'Advances in Cell Aging and Gerontology,' this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters.This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas. Englisch.

Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Aging occurs at the level of individual cells, a complex interplay between intrinsic 'programming' and exogenous 'wear and tear', with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, 'The Role of DNA Damage and Repair in Cell Aging' provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.As part of a series entitled 'Advances in Cell Aging and Gerontology,' this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters.This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.