Structure Activity Relationship of Drugs of Abuse

Language: English

Published by LAP LAMBERT Academic Publishing Dez 2018, 2018

613993267X / 9786139932672

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This item is printed on demand - Print on Demand Titel. Neuware -Structures of novel psychoactive substances are based on the structure activity relationship (SAR) of existing drugs of abuse. The study identified links between structural modifications and toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. Literature review identified the structural backbone, toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. SAR of cannabinoids, cathinones and opioids was based on amino alkylindoles, cathinone derivatives and fentanyl derivatives. Synthetic cannabinoids XLR-11 and MDMB-CHMICA have been linked to acute kidney injury due to over stimulation of CB1 receptors. The synthetic cathinones MDPV and ¿-PVP cause a higher occurrence of psychosis and delirium compared to other synthetic cathinones due to inhibitory uptake effects at dopamine and norepinephrine transporters. Fentanyl analogues having a lower lipophilic value than fentanyl had a shorter duration of physiological effects compared to fentanyl analogues having higher lipophilic values than fentanyl. The study contributes to an explanation of the higher potencies, toxicities and adverse effects associated with synthetic drugs.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 268 pp. Englisch.

Seller Inventory # 9786139932672

Title
Structure Activity Relationship of Drugs of Abuse
Author
Kersty Axisa
Publisher
LAP LAMBERT Academic Publishing Dez 2018
Publication year
2018
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
613993267X
ISBN 13
9786139932672
Item weight
417 grams
Dimensions
220x150x17 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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