Formulation and Evaluation of Floating In-Situ Gel of Methotrexate
Language: English
Published by LAP LAMBERT Academic Publishing Mai 2015, 2015
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 47.68
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of the study was to prepare and evaluate floating in-situ gel of methotrexate to increase the gastric residence time resulting in sustained drug release in gastrointestinal tract. Methotrexate is anticancer drug. It shows the undesirable side effect due to their fast release in the gastrointestinal tract (GIT). Floating in situ gel was prepared by using in-situ gel forming polymers like sodium alginate and pectin. Drug-excipients compatibility was carried out by FT-IR study. A 3level 2factor full factorial design was applied to investigate the combined effect of sodium alginate concentration (X1) and calcium carbonate concentration (X2). Floating In situ gels were evaluated for floating lag time, % drug release at 1 hr and % drug release at 12 hrs. In addition to the above, floating in situ gels were also evaluated for, pH, Viscosity, gelling capacity, floating time, drug content. All formulation gave the satisfactory result in terms of floating lag time, % drug release at 1 hr, and 12 hrs. Drug release was depended on the concentration of the polymer and calcium carbonate used in formulation. 92 pp. Englisch.…
Seller Inventory # 9783659709432
- Title
- Formulation and Evaluation of Floating In-Situ Gel of Methotrexate
- Author
- Zil Patel
- Publisher
- LAP LAMBERT Academic Publishing Mai 2015
- Publication year
- 2015
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3659709433
- ISBN 13
- 9783659709432
- Item weight
- 155 grams
- Dimensions
- 220x150x6 mm
"Synopsis" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
| Item | 5 to 15 business days | 5 to 15 business days |
|---|---|---|
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BuchWeltWeit Ludwig Meier e.K.
Germany
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