Enhancing Irbesartan Bioavailability via Solid Dispersion

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2024, 2024

6208119715 / 9786208119713

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This item is printed on demand - Print on Demand Titel. Neuware -Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like ß-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ß-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ß-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ß-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 84 pp. Englisch.…

Seller Inventory # 9786208119713

Title
Enhancing Irbesartan Bioavailability via Solid Dispersion
Author
Rashmitha Vallala
Publisher
LAP LAMBERT Academic Publishing Sep 2024
Publication year
2024
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6208119715
ISBN 13
9786208119713
Item weight
143 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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