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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques - Softcover
Synopsis
Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 μg/ml) limits its bioavailability. This study aimed to improve Irbesartan’s solubility through solid dispersions using carriers like β-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. β-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug’s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that β-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using β-cyclodextrin in solid dispersions effectively enhances Irbesartan’s solubility and therapeutic potential in treating hypertension.
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Seller: Ria Christie Collections, Uxbridge, United Kingdom
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Published by
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Paperback
Seller: CitiRetail, Stevenage, United Kingdom
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Paperback. Condition: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Seller Inventory # 9786208119713
Quantity: 1 available
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Softcover
Seller: California Books, Miami, FL, U.S.A.
Seller rating 5 out of 5 stars
Condition: New. Seller Inventory # I-9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Published by
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Taschenbuch
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 84 pp. Englisch. Seller Inventory # 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion : Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension. Seller Inventory # 9786208119713
Quantity: 1 available
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Softcover
Seller: Majestic Books, Hounslow, United Kingdom
Seller rating 5 out of 5 stars
Condition: New. Print on Demand. Seller Inventory # 409339473
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Softcover
Seller: Books Puddle, New York, NY, U.S.A.
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Published by
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Paperback
Seller: AussieBookSeller, Truganina, VIC, Australia
Seller rating 5 out of 5 stars
Paperback. Condition: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Seller Inventory # 9786208119713
Quantity: 1 available
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Published by
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Softcover
Seller: Biblios, Frankfurt am main, HESSE, Germany
Seller rating 4 out of 5 stars
Condition: New. PRINT ON DEMAND. Seller Inventory # 18403814788
Quantity: 4 available
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Published by
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Neuware -Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 84 pp. Englisch. Seller Inventory # 9786208119713
Quantity: 2 available