DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients : Flow Cytometric Evaluation of DNA Content Analysis and Therapeutic Responses (Invitro Cytotoxicity) of Transitional Cell Carcinoma Patients

Language: English

Published by LAP LAMBERT Academic Publishing, 2010

3843364133 / 9783843364133

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Transitional Cell Carcinoma accounts for more than 90% of bladder cancer. DNA analysis is the second most important application of flow cytometry. DNA content of individual cells give information about their ploidy in tumours and the distribution of cells across the cell cycle. Tumor DNA content has been found to be of prognostic importance for patients with many malignant tumors, such as carcinoma of urinary bladder. In-vitro cytotoxic studies on patients own cultured tumor tissue cells was done for the optimum cytotoxic combination of chemotherapeutic drugs and immunomodulators. This study was proposed investigate the DNA content evaluation and invitro monitoring of cytotoxicity produced by various chemotherapeutic agents viz Doxorubicin, Mitomycin C and Cisplatin on cultured cancer cells of patients having superficial TCC, individually as well as in combination of immunomodulating agents BCG and interferon alpha- 2b.Out of 25 samples nine were were aneuploid, one diploid and one tetraploid.Grade II samples were 70%. Out of 22 samples on which cytotoxicity test performed, 36.4% showed maximum cytotoxicity to the combination therapy and 5 showed to BCG drug.…

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Title
DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients : Flow Cytometric Evaluation of DNA Content Analysis and Therapeutic Responses (Invitro Cytotoxicity) of Transitional Cell Carcinoma Patients
Author
Saurabh Varma
Publisher
LAP LAMBERT Academic Publishing
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3843364133
ISBN 13
9783843364133
Item weight
137 grams
Dimensions
220x150x6 mm

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Einbeck, Germany

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