AMINO ACID PRODRUGS OF ACYCLOVIR: OCULAR HERPES INFECTIONS : DESIGN OF AMINO ACID PRODRUGS OF ACYCLOVIR FOR IMPROVED BIOAVAILABILITY AND THERAPEUTIC ACTIVITY: UTILITY IN TREATING OCULAR HERPES INFECTIONS
Language: English
Published by VDM Verlag Dr. Müller, 2009
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 52.23
Quantity: 2 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Infection with herpes simplex virus (HSV) is the single most frequent cause of corneal opacities. Current available therapy for HSV keratitis involves the use of trifluorothymidine, idoxuridine and vidarabine. However, one of major problems associated with these drugs is their cytotoxicity. Acyclovir (ACV) with its selective mechanism of action can cause less cytotoxicity but its poor permeability across cellular barrier limits its utility. Thus, the development of a safe, long-acting, effective and stable topical antiviral drops that require less frequent dosing would represent a significant improvement. Recently design of prodrugs targeted to membrane transporters for improved efficacy and absorption proved highly successful. valacyclovir (VACV) is such a prodrug that increased the oral bioavailability of ACV by 3-5 fold in humans. Recently the presence of these transport systems on the corneal epithelium has been established in our laboratory. A series of novel water soluble amino acid ester prodrugs of ACV were thus synthesized. In conclusion more permeable, less cytotoxic Ser-acyclovir (SACV) exhibited excellent antiviral activity against HSV viruses.…
Seller Inventory # 9783639151367
- Title
- AMINO ACID PRODRUGS OF ACYCLOVIR: OCULAR HERPES INFECTIONS : DESIGN OF AMINO ACID PRODRUGS OF ACYCLOVIR FOR IMPROVED BIOAVAILABILITY AND THERAPEUTIC ACTIVITY: UTILITY IN TREATING OCULAR HERPES INFECTIONS
- Author
- Suresh Katragadda
- Publisher
- VDM Verlag Dr. Müller
- Publication year
- 2009
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3639151364
- ISBN 13
- 9783639151367
- Item weight
- 255 grams
- Dimensions
- 22.00x15.00x0.90 cm
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|---|---|---|
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