Pharmacokinetic study of solid dispersion tablet of Kariyat extract: Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract - Softcover
Synopsis
Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable.
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Pharmacokinetic study of solid dispersion tablet of Kariyat extract
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LAP LAMBERT Academic Publishing Jul 2022, 2022
ISBN 10: 6205487144
ISBN 13: 9786205487143
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable. 68 pp. Englisch. Seller Inventory # 9786205487143
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Pharmacokinetic study of solid dispersion tablet of Kariyat extract
Published by
LAP Lambert Academic Publishing, 2022
ISBN 10: 6205487144
ISBN 13: 9786205487143
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Seller: moluna, Greven, Germany
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was foun. Seller Inventory # 692529905
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Pharmacokinetic study of solid dispersion tablet of Kariyat extract
Published by
LAP LAMBERT Academic Publishing Jul 2022, 2022
ISBN 10: 6205487144
ISBN 13: 9786205487143
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Neuware -Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch. Seller Inventory # 9786205487143
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Pharmacokinetic study of solid dispersion tablet of Kariyat extract : Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract
Published by
LAP LAMBERT Academic Publishing, 2022
ISBN 10: 6205487144
ISBN 13: 9786205487143
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable. Seller Inventory # 9786205487143
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Pharmacokinetic study of solid dispersion tablet of Kariyat extract | Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract
Published by
LAP LAMBERT Academic Publishing, 2022
ISBN 10: 6205487144
ISBN 13: 9786205487143
New
Taschenbuch
Seller: preigu, Osnabrück, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Pharmacokinetic study of solid dispersion tablet of Kariyat extract | Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract | Sachin Annasaheb Nitave (u. a.) | Taschenbuch | Englisch | 2022 | LAP LAMBERT Academic Publishing | EAN 9786205487143 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 123354920