Formulation Of Methylprednisolone Colon Targeted Tablets - Softcover

Kumar, Vasanth; Kumar, Sateesh; Kumar, Vijaya

 
9783659348686: Formulation Of Methylprednisolone Colon Targeted Tablets
Softcover
ISBN 10: 3659348686 ISBN 13: 9783659348686
Publisher: LAP LAMBERT Academic Publishing, 2013

Synopsis

The intent of current investigation is to make colon targeting methylprednisolone compression coated tablets using time dependent polymer hydroxypropyl methylcellulose and pH sensitive polymer Eudragit S100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The prepared formulations were optimized using dissolution tests and evaluated for colonic delivery by x-ray imaging and pharmacokinetic studies in healthy humans. The optimized formulation of methylprednisolone showed 10.52±0.68% in the initial lag period of 5 h followed by progressive release up to 101.43±3.33% for 24 h. The x-ray imaging study in human volunteers illustrated that the tablets arrived to colon with no loss of integrity in the upper gastrointestinal tract. Cmax of colon targeted compression coated tablets was 10324.83 ng/ml at Tmax 10 h which clearly indicates the capability of compression coated tablets to give colon targeting.

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About the Author

Vasanth Kumar is a post graduate student doing his Master of pharmacy in Pharmaceutical at Jangaon Institute of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh. After completing his graduation in the year 2012,he has working as a SAS Programmer in Life Sciences Pvt. Ltd. HYD.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2013
Language
English
ISBN 10 
3659348686
ISBN 13 
9783659348686
Binding
Paperback
Number of pages
116